Stem Leydig cell differentiation: Gene expression during development of the adult rat population of Leydig cells

Biology of Reproduction

Volumn 85, Issue 6, 2011, Pages 1161-1166

  Stanley, Erin L ^a   Johnston, Daniel S ^b   Fan, Jinjiang ^c   Papadopoulos, Vassilios ^c   Chen, Haolin ^a   Ge, Ren Shan ^d   Zirkin, Barry R ^a   Jelinsky, Scott A ^b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b PFIZER INC   (United States)

^c RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d POPULATION COUNCIL   (United States)

Author keywords

Gene expression; Leydig cells; Stem cells; Testis

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL; STEROIDOGENESIS;

ADULT STEM CELLS; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; LEYDIG CELLS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84855385458     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.091850     Document Type: Article

References (35)

1. Haider SG, Passia D, Overmeyer G. Studies on the fetal and postnatal development of rat Leydig cells employing 3β-hydroxysteroid dehydrogenase activity. Acta Histochem Suppl 1986; 32:197-202.
2. Shan LX, Hardy MP. Developmental changes in levels of luteinizing hormone receptor and androgen receptor in rat Leydig cells. Endocrinology 1992; 131:1107-1114.
3. Benton L, Shan X, Hardy MP. Differentiation of adult Leydig cells. J Steroid Biochem Mol Biol 1995; 53:61-68.
4. Ge RS, Hardy MP. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Endocrinology 1998; 139:3787-3795.
5. Hardy MP, Zirkin BR, Ewing LL. Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat. Endocrinology 1989; 124:762-770.
6. Ge RS, Dong Q, Sottas CM, Papadopoulos V, Zirkin BR, Hardy MP. In search of rat stem Leydig cells: identification, isolation, and lineagespecific development. Proc Natl Acad Sci U S A 2006; 103:2719-2724.
7. Ge RS, Dong Q, Sottas CM, Chen H, Zirkin BR, Hardy MP. Gene expression in rat Leydig cells during development from the progenitor to adult stage: a cluster analysis. Biol Reprod 2005; 72:1405-1415.
8. Hardy MP, Kelce WR, Klinefelter GR, Ewing LL. Differentiation of Leydig cell precursors in vitro: a role for androgen. Endocrinology 1990; 127:488-490.
9. Klinefelter GR, Kelce WR, Hardy MP. Isolation and culture of Leydig cells from adult rats. Methods Toxicol 1993; 3A:166-181.
10. Klinefelter GR, Hall PF, Ewing LL. Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure. Biol Reprod 1987; 36:769-783.
11. Payne AH, Downing JR, Wong KL. Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 1980; 106:1424-1429.
12. Rosca AM, Burlacu A. Isolation of a mouse bone marrow population enriched in stem and progenitor cells by centrifugation on a Percoll gradient. Biotechnol Appl Biochem 2010; 55:199-208.
13. Barenco M, Stark J, Brewer D, Tomescu D, Callard R, Hubank M. Correction of scaling mismatches in oligonucleotide mircroarray data. BMC Bioinformatics 2006; 7:251.
14. Chen H, Ge RS, Zirkin BR. Leydig cells: from stem cells to aging. Mol Cell Endocrinol 2009; 306:9-16.
15. Chagastelles PC, Nardi NB, Camassola M. Biology and applications of mesenchymal stem cells. Sci Prog 2010; 93:113-127.
16. Laird DJ, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth and disease. Cell 2008; 132:612-630.
17. Othsuka T, Sakamoto M, Guillemot F, Kageyama R. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J Biol Chem 2001; 276:30467-30474.
18. Kageyama R, Ohtuska T, Kobayashi T. Roles of Hes genes in neural development. Dev Growth Differ 2008; 50(Suppl 1):S97-S103.
19. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signaling downstream of activated mammalian Notch. Nature 1995; 377:355-358.
20. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signaling requires ligandinduced proteolytic release of intracellular domain. Nature 1998; 393:382-386.
21. Zine A, Aubert A, Qiu J, Therianos S, Guillemot F, Kageyama R, de Ribaupierre F. Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. J Neurosci 2001; 21:4712-4720.
22. Tang H, Brennan J, Karl J, Hamada Y, Raetzman L, Capel B. Notch signaling maintains Leydig progenitor cells in the mouse testis. Development 2008; 135:3745-3753.
23. Luo X, Ikeda Y, Parker KL. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 1994; 77:481-490.
24. Rone MB, Fan J, Papadopoulos V. Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta 2009; 1791:646-658.
25. Alpy F, Tomasetto C. Give lipids a START: the StAR-related lipid transfer (START) domain in mammals. J Cell Sci 2005; 118:2791-2801.
26. Bott RC, McFee RM, Clopton DT, Toombs C, Cupp AS. Vasculature endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat. Biol Reprod 2006; 75:56-67.
27. Bott RC, Clopton DT, Cupp AS. A proposed role for VEGF isoforms in sex-specific vasculature development in the gonad. Reprod Domest Anim 2008; 43(Suppl 2):310-316.
28. Ferrara N. VEGF: an update on biological and therapeutic aspects. Curr Opin Biotechnol 2000; 11:617-624.
29. Olsson AK, Dimberg A, Freuger J, Claesson-Welch L. VEGF receptor signaling-in control of vascular function. Nature Rev 2006; 7:359-371.
30. Beattie J, McIntosh L, van der Walle CF. Cross-talk between the insulinlike growth factor (IGF) axis and membrane integrins to regulate cell physiology. J Cell Physiol 2010; 224:605-611.
31. Maekawa M, Kamimura K, Nagano T. Peritubular myoid cells in the testis: their structure and function. Arch Histol Cytol 1996; 59:1-13.
32. Muller-Sieburg CE, Deryugina E. The stromal cells' guide to the stem cell universe. Stem Cells 1995; 13:477-486.
33. Le Friec G, Kemper C. Complement: coming full circle. Arch Immunol Ther Exp 2009; 57:393-407.
34. Hornsby PJ, Crivello JF. The role of lipid peroxidation and biological antioxidants in the function of the adrenal cortex. Mol Cell Endocrinol 1983; 30:123-147.
35. Peltola V, Huhtaniemi I, Metsa-Ketela T, Ahotupa M. Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology 1996; 137:105-112.