Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9)

Endocrinology

Volumn 153, Issue 4, 2012, Pages 1948-1958

  Ludbrook, Louisa M ^a,b   Bernard, Pascal ^a   Bagheri Fam, Stefan ^a,b   Ryan, Janelle ^a   Sekido, Ryohei ^c   Wilhelm, Dagmar ^d   Lovell Badge, Robin ^c   Harley, Vincent R ^a,b  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; CYTOCHROME P450 17; CYTOCHROME P450 17A1; FORKHEAD BOX L2; FORKHEAD TRANSCRIPTION FACTOR; MUELLERIAN INHIBITING FACTOR; NUCLEAR RECEPTOR DAX 1; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE ACTIVATION; GENE OVEREXPRESSION; GENE REPRESSION; GRANULOSA CELL; HETEROZYGOTE; KARYOTYPE 46,XY; LEYDIG CELL; MALE; MOUSE; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTEIN BINDING; SEX DIFFERENTIATION DISORDER; SRY GENE; TESTIS DEVELOPMENT; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; DAX-1 ORPHAN NUCLEAR RECEPTOR; DISORDERS OF SEX DEVELOPMENT; DNA-BINDING PROTEINS; FEMALE; FETUS; GENOTYPE; GONADAL DYSGENESIS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; SEX-DETERMINING REGION Y PROTEIN; SOX9 TRANSCRIPTION FACTOR; STEROIDOGENIC FACTOR 1; TESTIS;

EID: 84859409094     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1428     Document Type: Article

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