메뉴 건너뛰기




Volumn 130, Issue 3, 2005, Pages 283-291

What have gonadotrophin overexpressing transgenic mice taught us about gonadal function?

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADOTROPIN; GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE; TUMOR PROMOTER;

EID: 24944532006     PISSN: 14701626     EISSN: None     Source Type: Journal    
DOI: 10.1530/rep.1.00661     Document Type: Review
Times cited : (34)

References (70)
  • 1
    • 24944489823 scopus 로고    scopus 로고
    • Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level; a study on hCG overexpressing transgenic mice
    • In Press
    • Ahtiainen P, Rulli S, Pelliniemi LJ, Toppari J, Poutanen M & Huhtaniemi I 2005 Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level; a study on hCG overexpressing transgenic mice. Oncogene In Press.
    • (2005) Oncogene
    • Ahtiainen, P.1    Rulli, S.2    Pelliniemi, L.J.3    Toppari, J.4    Poutanen, M.5    Huhtaniemi, I.6
  • 2
    • 1642546562 scopus 로고    scopus 로고
    • Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: Evidence from genetic models of isolated FSH action
    • Allan CM, Garcia A, Spaliviero J, Zhang FP, Jimenez M, Huhtaniemi I & Handelsman DJ 2004 Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action. Endocrinology 145 1587-1593.
    • (2004) Endocrinology , vol.145 , pp. 1587-1593
    • Allan, C.M.1    Garcia, A.2    Spaliviero, J.3    Zhang, F.P.4    Jimenez, M.5    Huhtaniemi, I.6    Handelsman, D.J.7
  • 3
    • 0030743165 scopus 로고    scopus 로고
    • Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumour suppressor genes
    • Amsterdam A & Selvaraj N 1997 Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumour suppressor genes. Endocrine Reviews 18 435-461.
    • (1997) Endocrine Reviews , vol.18 , pp. 435-461
    • Amsterdam, A.1    Selvaraj, N.2
  • 4
    • 0036217072 scopus 로고    scopus 로고
    • The lutropin/choriogonadotropin receptor, a 2002 perspective
    • Ascoli M, Fanelli F & Segaloff DL 2002 The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocrine Reviews 23 141-174.
    • (2002) Endocrine Reviews , vol.23 , pp. 141-174
    • Ascoli, M.1    Fanelli, F.2    Segaloff, D.L.3
  • 7
    • 0036320874 scopus 로고    scopus 로고
    • Minireview: Genetic models for the study of gonadotropin actions
    • Burns KH & Matzuk MM 2002 Minireview: genetic models for the study of gonadotropin actions. Endocrinology 143 2823-2835.
    • (2002) Endocrinology , vol.143 , pp. 2823-2835
    • Burns, K.H.1    Matzuk, M.M.2
  • 9
    • 0036082029 scopus 로고    scopus 로고
    • Detection of hCG in trophoblastic disease. The USA hCG reference service experience
    • Cole LA & Butler S 2002 Detection of hCG in trophoblastic disease. The USA hCG reference service experience. Journal of Reproductive Medicine 47 433-444.
    • (2002) Journal of Reproductive Medicine , vol.47 , pp. 433-444
    • Cole, L.A.1    Butler, S.2
  • 10
    • 0017089789 scopus 로고
    • Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary
    • Conti M, Harwood JP, Hsueh AJ, Dufau ML & Catt KJ 1976 Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary. Journal of Biological Chemistry 251 7729-7731.
    • (1976) Journal of Biological Chemistry , vol.251 , pp. 7729-7731
    • Conti, M.1    Harwood, J.P.2    Hsueh, A.J.3    Dufau, M.L.4    Catt, K.J.5
  • 11
    • 0033305033 scopus 로고    scopus 로고
    • Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse
    • Couse JF, Bunch DO, Lindzey J, Schomberg DW & Korach KS 1999a Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse. Endocrinology 140 5855-5865.
    • (1999) Endocrinology , vol.140 , pp. 5855-5865
    • Couse, J.F.1    Bunch, D.O.2    Lindzey, J.3    Schomberg, D.W.4    Korach, K.S.5
  • 13
    • 0036865059 scopus 로고    scopus 로고
    • Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): A review
    • Delvigne A & Rozenberg S 2002 Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Human Reproduction Update 8 559-577.
    • (2002) Human Reproduction Update , vol.8 , pp. 559-577
    • Delvigne, A.1    Rozenberg, S.2
  • 14
    • 0018642101 scopus 로고
    • Androgen biosynthesis in Leydig cells after testicular desensitization by luteinizing hormone-releasing hormone and human chorionic gonadotropin
    • Dufau ML, Cigorraga S, Baukal AJ, Sorrell S, Bator JM, Neubauer JF & Catt KJ 1979 Androgen biosynthesis in Leydig cells after testicular desensitization by luteinizing hormone-releasing hormone and human chorionic gonadotropin. Endocrinology 105 1314-1321.
    • (1979) Endocrinology , vol.105 , pp. 1314-1321
    • Dufau, M.L.1    Cigorraga, S.2    Baukal, A.J.3    Sorrell, S.4    Bator, J.M.5    Neubauer, J.F.6    Catt, K.J.7
  • 15
    • 0029969771 scopus 로고    scopus 로고
    • Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
    • Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB & Korach KS 1996 Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 137 4796-4805.
    • (1996) Endocrinology , vol.137 , pp. 4796-4805
    • Eddy, E.M.1    Washburn, T.F.2    Bunch, D.O.3    Goulding, E.H.4    Gladen, B.C.5    Lubahn, D.B.6    Korach, K.S.7
  • 16
    • 0000302448 scopus 로고
    • The gonad-stimulating and the luteinizing hormones of the anterior lobe of the hypophysis
    • Fevold SL, Hisaw FL & Leonard SL 1931 The gonad-stimulating and the luteinizing hormones of the anterior lobe of the hypophysis. American Journal of Physiology 97 291-301.
    • (1931) American Journal of Physiology , vol.97 , pp. 291-301
    • Fevold, S.L.1    Hisaw, F.L.2    Leonard, S.L.3
  • 18
    • 0030785545 scopus 로고    scopus 로고
    • Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary
    • Flaws JA, Abbud R, Mann RJ, Nilson JH & Hirshfield AN 1997 Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary. Biology of Reproduction 57 1233-1237.
    • (1997) Biology of Reproduction , vol.57 , pp. 1233-1237
    • Flaws, J.A.1    Abbud, R.2    Mann, R.J.3    Nilson, J.H.4    Hirshfield, A.N.5
  • 20
  • 21
    • 0028133618 scopus 로고
    • Differential effects of the administration of human chorionic gonadotropin to postnatal rats
    • Gaytan F, Pinilla L, Romero JL & Aguilar E 1994 Differential effects of the administration of human chorionic gonadotropin to postnatal rats. Journal of Endocrinology 142 527-534.
    • (1994) Journal of Endocrinology , vol.142 , pp. 527-534
    • Gaytan, F.1    Pinilla, L.2    Romero, J.L.3    Aguilar, E.4
  • 22
    • 0033998794 scopus 로고    scopus 로고
    • Declining ovarian cancer rates in US women in relation to parity and oral contraceptive use
    • Gnagy S, Ming EE, Devesa SS, Hartge P & Whittemore AS 2000 Declining ovarian cancer rates in US women in relation to parity and oral contraceptive use. Epidemiology 11 102-105.
    • (2000) Epidemiology , vol.11 , pp. 102-105
    • Gnagy, S.1    Ming, E.E.2    Devesa, S.S.3    Hartge, P.4    Whittemore, A.S.5
  • 23
    • 0029913238 scopus 로고    scopus 로고
    • An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man
    • Gromoll J, Simoni M & Nieschlag E 1996 An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. Journal of Clinical Endocrinology and Metabolism 81 1367-1370.
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 1367-1370
    • Gromoll, J.1    Simoni, M.2    Nieschlag, E.3
  • 24
    • 24644461526 scopus 로고    scopus 로고
    • Mutations in human gonadotropin and gonadotropin receptor genes
    • In Press
    • Huhtaniemi IT & Themmen APN 2005 Mutations in human gonadotropin and gonadotropin receptor genes. Endocrine In Press.
    • (2005) Endocrine
    • Huhtaniemi, I.T.1    Themmen, A.P.N.2
  • 25
    • 0037155004 scopus 로고    scopus 로고
    • Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function
    • Huhtaniemi I, Zhang FP, Kero J, Hamalainen T & Poutanen M 2002 Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function. Molecular and Cellular Endocrinology 87 49-56.
    • (2002) Molecular and Cellular Endocrinology , vol.87 , pp. 49-56
    • Huhtaniemi, I.1    Zhang, F.P.2    Kero, J.3    Hamalainen, T.4    Poutanen, M.5
  • 27
    • 0035944837 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone-receptor antagonists
    • Huirne JA & Lambalk CB 2001 Gonadotropin-releasing hormone-receptor antagonists. Lancet 358 1793-1803.
    • (2001) Lancet , vol.358 , pp. 1793-1803
    • Huirne, J.A.1    Lambalk, C.B.2
  • 28
    • 0027416348 scopus 로고
    • Regulation of chorionic gonadotropin gene expression
    • Jameson JL & Hollenberg AN 1993 Regulation of chorionic gonadotropin gene expression. Endocrine Reviews 14 203-221.
    • (1993) Endocrine Reviews , vol.14 , pp. 203-221
    • Jameson, J.L.1    Hollenberg, A.N.2
  • 29
    • 0030787593 scopus 로고    scopus 로고
    • Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin α-subunit promoter/simian virus 40 T antigen fusion gene
    • Kananen K, Rilianawati, Paukku T, Markkula M, Rainio EM & Huhtanemi IT 1997 Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin α-subunit promoter/simian virus 40 T antigen fusion gene. Endocrinology 138 3521-3531.
    • (1997) Endocrinology , vol.138 , pp. 3521-3531
    • Kananen, K.1    Rilianawati Paukku, T.2    Markkula, M.3    Rainio, E.M.4    Huhtanemi, I.T.5
  • 30
    • 0034602808 scopus 로고    scopus 로고
    • Luteinizing hormone induction of ovarian tumors: Oligogenic differences between mouse strains dictates tumor disposition
    • Keri RA, Lozada KL, Abdul-Karim FW, Nadeau JN & Nilson JH 2000 Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition. PNAS 97 383-387.
    • (2000) PNAS , vol.97 , pp. 383-387
    • Keri, R.A.1    Lozada, K.L.2    Abdul-Karim, F.W.3    Nadeau, J.N.4    Nilson, J.H.5
  • 32
    • 0032742479 scopus 로고    scopus 로고
    • Review: Gonadotropins and development of ovarian cancer
    • Konishi I, Kuroda H & Mandai M 1999 Review: gonadotropins and development of ovarian cancer. Oncology 57 45-48.
    • (1999) Oncology , vol.57 , pp. 45-48
    • Konishi, I.1    Kuroda, H.2    Mandai, M.3
  • 33
    • 0029742472 scopus 로고    scopus 로고
    • Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice
    • Kumar TR, Wang Y & Matzuk MM 1996 Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice. Endocrinology 137 4210-4216.
    • (1996) Endocrinology , vol.137 , pp. 4210-4216
    • Kumar, T.R.1    Wang, Y.2    Matzuk, M.M.3
  • 34
    • 0033304622 scopus 로고    scopus 로고
    • Transgenic models to study gonadotropin function: The role of follicle-stimulating hormone in gonadal growth and tumorigenesis
    • Kumar TR, Palapattu G, Wang P, Woodruff TK, Boime I, Byrne MC & Matzuk MM 1999 Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis. Molecular Endocrinology 13 851-886.
    • (1999) Molecular Endocrinology , vol.13 , pp. 851-886
    • Kumar, T.R.1    Palapattu, G.2    Wang, P.3    Woodruff, T.K.4    Boime, I.5    Byrne, M.C.6    Matzuk, M.M.7
  • 35
    • 24944486224 scopus 로고    scopus 로고
    • What have we learned about gonadotropin function from gonadotropin subunit and receptor mice?
    • Kumar TR 2005 What have we learned about gonadotropin function from gonadotropin subunit and receptor mice? Reproduction 130 293-302.
    • (2005) Reproduction , vol.130 , pp. 293-302
    • Kumar, T.R.1
  • 36
  • 37
  • 38
    • 0033279007 scopus 로고    scopus 로고
    • Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure
    • Mann RJ, Keri RA & Nilson JH 1999 Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure. Endocrinology 140 2592-2601.
    • (1999) Endocrinology , vol.140 , pp. 2592-2601
    • Mann, R.J.1    Keri, R.A.2    Nilson, J.H.3
  • 39
    • 0042809619 scopus 로고    scopus 로고
    • Consequences of elevated luteinizing hormone on diverse physiological systems: Use of the LHbetaCTP transgenic mouse as a model of ovarian hyperstimulation-induced pathophysiology
    • Mann RJ, Keri RA & Nilson JH 2003 Consequences of elevated luteinizing hormone on diverse physiological systems: use of the LHbetaCTP transgenic mouse as a model of ovarian hyperstimulation-induced pathophysiology. Recent Progress in Hormone Research 58 343-375.
    • (2003) Recent Progress in Hormone Research , vol.58 , pp. 343-375
    • Mann, R.J.1    Keri, R.A.2    Nilson, J.H.3
  • 41
    • 0026621796 scopus 로고
    • Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
    • Matzuk MM, Finegold MJ, Su JG, Hsueh AJ & Bradley A 1992 Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360 313-319.
    • (1992) Nature , vol.360 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.G.3    Hsueh, A.J.4    Bradley, A.5
  • 42
    • 0038112173 scopus 로고    scopus 로고
    • Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice
    • Matzuk MM, DeMayo FJ, Hadsell LA & Kumar TR 2003 Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice. Biology of Reproduction 69 338-346.
    • (2003) Biology of Reproduction , vol.69 , pp. 338-346
    • Matzuk, M.M.1    DeMayo, F.J.2    Hadsell, L.A.3    Kumar, T.R.4
  • 43
    • 17844374094 scopus 로고    scopus 로고
    • Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex
    • Meehan TP, Harmon BG, Overcast ME, Yu KK, Camper SA, Puett D & Narayan P 2005 Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex. Journal of Molecular Endocrinology 34 489-503.
    • (2005) Journal of Molecular Endocrinology , vol.34 , pp. 489-503
    • Meehan, T.P.1    Harmon, B.G.2    Overcast, M.E.3    Yu, K.K.4    Camper, S.A.5    Puett, D.6    Narayan, P.7
  • 44
    • 0038621388 scopus 로고    scopus 로고
    • High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene
    • Mikola M, Kero J, Nilson JH, Keri RA, Poutanen M & Huhtaniemi I 2003 High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene. Oncogene 22 3269-3278.
    • (2003) Oncogene , vol.22 , pp. 3269-3278
    • Mikola, M.1    Kero, J.2    Nilson, J.H.3    Keri, R.A.4    Poutanen, M.5    Huhtaniemi, I.6
  • 45
    • 0031565929 scopus 로고    scopus 로고
    • Role of imprinting in abnormal human development
    • Mutter GL 1997 Role of imprinting in abnormal human development. Mutation Research 396 141-147.
    • (1997) Mutation Research , vol.396 , pp. 141-147
    • Mutter, G.L.1
  • 46
    • 0036913852 scopus 로고    scopus 로고
    • Yoked complexes of human choriogonadotropin and the lutropin receptor: Evidence that monomeric individual subunits are inactive
    • Narayan P, Gray J & Puett D 2002 Yoked complexes of human choriogonadotropin and the lutropin receptor: evidence that monomeric individual subunits are inactive. Molecular Endocrinology 16 2733-2745.
    • (2002) Molecular Endocrinology , vol.16 , pp. 2733-2745
    • Narayan, P.1    Gray, J.2    Puett, D.3
  • 47
    • 85047681722 scopus 로고    scopus 로고
    • Ovulatory surges of hCG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome
    • Owens GE, Keri RA & Nilson JH 2002 Ovulatory surges of hCG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. Molecular Endocrinology 16 1230-1242.
    • (2002) Molecular Endocrinology , vol.16 , pp. 1230-1242
    • Owens, G.E.1    Keri, R.A.2    Nilson, J.H.3
  • 48
    • 0036146528 scopus 로고    scopus 로고
    • Editorial: The postnatal gonadotropin and sex steroid surge - Insights from the androgen insensitivity syndrome
    • Quigley CA 2002 Editorial: the postnatal gonadotropin and sex steroid surge - insights from the androgen insensitivity syndrome. Journal of Clinical Endocrinology and Metabolism 87 24-28.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 24-28
    • Quigley, C.A.1
  • 49
    • 22144464436 scopus 로고    scopus 로고
    • Fertility in LH receptor knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal LH action
    • In Press
    • Pakarainen T, Zhang F-P, Poutanen M & Huhtaniemi I 2005 Fertility in LH receptor knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal LH action. Journal of Clinical Investigation In Press.
    • (2005) Journal of Clinical Investigation
    • Pakarainen, T.1    Zhang, F.-P.2    Poutanen, M.3    Huhtaniemi, I.4
  • 51
    • 4444327178 scopus 로고    scopus 로고
    • Review of epidemiological evidence for reproductive and hormonal factors in relation to the risk of epithelial ovarian malignancies
    • Riman T, Nilsson S & Persson IR 2004 Review of epidemiological evidence for reproductive and hormonal factors in relation to the risk of epithelial ovarian malignancies. Acta Obstetrica et Gynecologica Scandinavica 83 783-795.
    • (2004) Acta Obstetrica Et Gynecologica Scandinavica , vol.83 , pp. 783-795
    • Riman, T.1    Nilsson, S.2    Persson, I.R.3
  • 52
    • 0020076654 scopus 로고
    • The effects of chronic human chorionic gonadotropin treatment on Leydig cell function
    • Risbridger GP, Robertson DM & de Kretser DM 1982 The effects of chronic human chorionic gonadotropin treatment on Leydig cell function. Endocrinology 110 138-145.
    • (1982) Endocrinology , vol.110 , pp. 138-145
    • Risbridger, G.P.1    Robertson, D.M.2    de Kretser, D.M.3
  • 53
    • 0032477328 scopus 로고    scopus 로고
    • Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone
    • Risch HA 1998 Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. Journal of the National Cancer Institute 90 1774-1786.
    • (1998) Journal of the National Cancer Institute , vol.90 , pp. 1774-1786
    • Risch, H.A.1
  • 54
    • 0028923296 scopus 로고
    • Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors
    • Risma KA, Clay CM, Nett TM, Wagner T, Yun J & Nilson JH 1995 Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. PNAS 92 1322-1326.
    • (1995) PNAS , vol.92 , pp. 1322-1326
    • Risma, K.A.1    Clay, C.M.2    Nett, T.M.3    Wagner, T.4    Yun, J.5    Nilson, J.H.6
  • 55
    • 0030741673 scopus 로고    scopus 로고
    • Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology
    • Risma KA, Hirshfield AN & Nilson JH 1997 Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology. Endocrinology 138 3540-3547.
    • (1997) Endocrinology , vol.138 , pp. 3540-3547
    • Risma, K.A.1    Hirshfield, A.N.2    Nilson, J.H.3
  • 56
    • 11844254836 scopus 로고    scopus 로고
    • Spontaneous ovarian hyperstimulation caused by a follicle-stimulating hormone-secreting pituitary adenoma
    • Roberts JE, Spandorfer S, Fasouliotis SJ, Lin K & Rosenwaks Z 2005 Spontaneous ovarian hyperstimulation caused by a follicle-stimulating hormone-secreting pituitary adenoma. Fertility and Sterility 83 208-210.
    • (2005) Fertility and Sterility , vol.83 , pp. 208-210
    • Roberts, J.E.1    Spandorfer, S.2    Fasouliotis, S.J.3    Lin, K.4    Rosenwaks, Z.5
  • 57
    • 0036772574 scopus 로고    scopus 로고
    • Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin
    • Rulli SB, Kuorelahti AI, Karaer O, Pelliniemi L, Poutanen M & Huhtaniemi IT 2002 Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology 143 4084-4095.
    • (2002) Endocrinology , vol.143 , pp. 4084-4095
    • Rulli, S.B.1    Kuorelahti, A.I.2    Karaer, O.3    Pelliniemi, L.4    Poutanen, M.5    Huhtaniemi, I.T.6
  • 58
    • 0242552024 scopus 로고    scopus 로고
    • Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin
    • Rulli SB, Ahtiainen P, Makela S, Toppari J, Poutanen M & Huhtaniemi I 2003 Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin. Endocrinology 144 4980-4990.
    • (2003) Endocrinology , vol.144 , pp. 4980-4990
    • Rulli, S.B.1    Ahtiainen, P.2    Makela, S.3    Toppari, J.4    Poutanen, M.5    Huhtaniemi, I.6
  • 60
    • 0033279408 scopus 로고    scopus 로고
    • Targeted disruption of the estrogen receptor-alpha gene in female mice: Characterization of ovarian responses and phenotype in the adult
    • Schomberg DW, Couse JF, Mukherjee A, Lubahn DB, Sar M, Mayo KE & Korach KS 1999 Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology 140 2733-2744.
    • (1999) Endocrinology , vol.140 , pp. 2733-2744
    • Schomberg, D.W.1    Couse, J.F.2    Mukherjee, A.3    Lubahn, D.B.4    Sar, M.5    Mayo, K.E.6    Korach, K.S.7
  • 61
    • 0025320221 scopus 로고
    • Effect of LH injections on testicular steroidogenesis, cholesterol sidechain cleavage P450 mRNA content and Leydig cell morphology in hypogonadal mice
    • Scott IS, Charlton HM, Cox BS, Grocock CA, Sheffield JW & O'Shaughnessy PJ 1990 Effect of LH injections on testicular steroidogenesis, cholesterol sidechain cleavage P450 mRNA content and Leydig cell morphology in hypogonadal mice. Journal of Endocrinology 125 131-138.
    • (1990) Journal of Endocrinology , vol.125 , pp. 131-138
    • Scott, I.S.1    Charlton, H.M.2    Cox, B.S.3    Grocock, C.A.4    Sheffield, J.W.5    O'Shaughnessy, P.J.6
  • 62
    • 0031457992 scopus 로고    scopus 로고
    • The follicle-stimulating hormone receptor: Biochemistry, molecular biology, physiology, and pathophysiology
    • Simoni M, Gromoll J & Nieschlag E 1997 The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocrine Reviews 18 739-773.
    • (1997) Endocrine Reviews , vol.18 , pp. 739-773
    • Simoni, M.1    Gromoll, J.2    Nieschlag, E.3
  • 63
    • 84940140720 scopus 로고
    • Experimental evidence of the role of anterior pituitary in development and regulation of gonads
    • Smith PE & Engle ET 1927 Experimental evidence of the role of anterior pituitary in development and regulation of gonads. American Journal of Anatomy 40 159-161.
    • (1927) American Journal of Anatomy , vol.40 , pp. 159-161
    • Smith, P.E.1    Engle, E.T.2
  • 67
    • 0033711033 scopus 로고    scopus 로고
    • Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function
    • Themmen APN & Huhtaniemi IT 2000 Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocrine Reviews 21 551-583.
    • (2000) Endocrine Reviews , vol.21 , pp. 551-583
    • Themmen, A.P.N.1    Huhtaniemi, I.T.2
  • 68
    • 24944501149 scopus 로고    scopus 로고
    • An update of the pathophysiology of human gonadotrophin subunit and receptor mutations and polymorphisms
    • Themmen APN 2005 An update of the pathophysiology of human gonadotrophin subunit and receptor mutations and polymorphisms. Reproduction 130 263-274.
    • (2005) Reproduction , vol.130 , pp. 263-274
    • Themmen, A.P.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.