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Volumn 306, Issue 1-2, 2009, Pages 2-8

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: Data from mutant and genetically modified mice

Author keywords

Androgen; Gonadotrophins; Leydig cell; Sertoli cell; Testis

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CORTICOTROPIN; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

EID: 67349249354     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.11.005     Document Type: Review
Times cited : (75)

References (88)
  • 2
    • 0034457577 scopus 로고    scopus 로고
    • The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction
    • Abel M.H., Wootton A.N., Wilkins V., Huhtaniemi I., Knight P.G., and Charlton H.M. The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology 141 (2000) 1795-1803
    • (2000) Endocrinology , vol.141 , pp. 1795-1803
    • Abel, M.H.1    Wootton, A.N.2    Wilkins, V.3    Huhtaniemi, I.4    Knight, P.G.5    Charlton, H.M.6
  • 4
    • 0033937174 scopus 로고    scopus 로고
    • Studies of the onset of Leydig precursor cell differentiation in the prepubertal rat testis
    • Ariyaratne H.B., Mendis-Handagama S.M., Hales D.B., and Mason J.I. Studies of the onset of Leydig precursor cell differentiation in the prepubertal rat testis. Biol. Reprod. 63 (2000) 165-171
    • (2000) Biol. Reprod. , vol.63 , pp. 165-171
    • Ariyaratne, H.B.1    Mendis-Handagama, S.M.2    Hales, D.B.3    Mason, J.I.4
  • 6
    • 0034908014 scopus 로고    scopus 로고
    • Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice
    • Baker P.J., and O'Shaughnessy P.J. Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice. Reproduction 122 (2001) 227-234
    • (2001) Reproduction , vol.122 , pp. 227-234
    • Baker, P.J.1    O'Shaughnessy, P.J.2
  • 7
    • 0033087599 scopus 로고    scopus 로고
    • Expression of 3β-hydroxysteriod dehydrogenase type I and VI isoforms in the mouse testis during development
    • Baker P.J., Sha J.A., McBride M.W., Peng L., Payne A.H., and O'Shaughnessy P.J. Expression of 3β-hydroxysteriod dehydrogenase type I and VI isoforms in the mouse testis during development. Eur. J. Biochem. 260 (1999) 911-916
    • (1999) Eur. J. Biochem. , vol.260 , pp. 911-916
    • Baker, P.J.1    Sha, J.A.2    McBride, M.W.3    Peng, L.4    Payne, A.H.5    O'Shaughnessy, P.J.6
  • 8
    • 0345700294 scopus 로고    scopus 로고
    • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad
    • Brennan J., Tilmann C., and Capel B. Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev. 17 (2003) 800-810
    • (2003) Genes Dev. , vol.17 , pp. 800-810
    • Brennan, J.1    Tilmann, C.2    Capel, B.3
  • 9
    • 0022919252 scopus 로고
    • Differentiation of mammalian embryonic gonad
    • Byskov A. Differentiation of mammalian embryonic gonad. Physiol. Rev. 66 (1986) 77-112
    • (1986) Physiol. Rev. , vol.66 , pp. 77-112
    • Byskov, A.1
  • 10
    • 2342595087 scopus 로고    scopus 로고
    • Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells
    • Chang C., Chen Y.T., Yeh S.D., Xu Q., Wang R.S., Guillou F., Lardy H., and Yeh S. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 6876-6881
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 6876-6881
    • Chang, C.1    Chen, Y.T.2    Yeh, S.D.3    Xu, Q.4    Wang, R.S.5    Guillou, F.6    Lardy, H.7    Yeh, S.8
  • 11
    • 0017057119 scopus 로고
    • FSH stimulation of Leydig cell function in the hypophysectomized immature rat
    • Chen Y.I., Payne A.H., and Kelch R.P. FSH stimulation of Leydig cell function in the hypophysectomized immature rat. Proc. Soc. Exp. Biol. Med. 153 (1976) 473-475
    • (1976) Proc. Soc. Exp. Biol. Med. , vol.153 , pp. 473-475
    • Chen, Y.I.1    Payne, A.H.2    Kelch, R.P.3
  • 12
    • 0033709190 scopus 로고    scopus 로고
    • Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules
    • Clark A.M., Garland K.K., and Russell L.D. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Biol. Reprod. 63 (2000) 1825-1838
    • (2000) Biol. Reprod. , vol.63 , pp. 1825-1838
    • Clark, A.M.1    Garland, K.K.2    Russell, L.D.3
  • 15
    • 0031796252 scopus 로고    scopus 로고
    • Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene
    • de Santa B.P., Bonneaud N., Boizet B., Desclozeaux M., Moniot B., Sudbeck P., Scherer G., Poulat F., and Berta P. Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene. Mol. Cell Biol. 18 (1998) 6653-6665
    • (1998) Mol. Cell Biol. , vol.18 , pp. 6653-6665
    • de Santa, B.P.1    Bonneaud, N.2    Boizet, B.3    Desclozeaux, M.4    Moniot, B.5    Sudbeck, P.6    Scherer, G.7    Poulat, F.8    Berta, P.9
  • 17
    • 0032506018 scopus 로고    scopus 로고
    • Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
    • Dierich A., Sairam M.R., Monaco L., Fimia G.M., Gansmuller A., LeMeur M., and Sassone-Corsi P. Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 13612-13617
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13612-13617
    • Dierich, A.1    Sairam, M.R.2    Monaco, L.3    Fimia, G.M.4    Gansmuller, A.5    LeMeur, M.6    Sassone-Corsi, P.7
  • 19
    • 34247846135 scopus 로고    scopus 로고
    • Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development
    • Eacker S.M., Shima J.E., Connolly C.M., Sharma M., Holdcraft R.W., Griswold M.D., and Braun R.E. Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development. Mol. Endocrinol. 21 (2007) 895-907
    • (2007) Mol. Endocrinol. , vol.21 , pp. 895-907
    • Eacker, S.M.1    Shima, J.E.2    Connolly, C.M.3    Sharma, M.4    Holdcraft, R.W.5    Griswold, M.D.6    Braun, R.E.7
  • 20
    • 0031973722 scopus 로고    scopus 로고
    • Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis
    • El Gehani F., Zhang F.P., Pakarinen P., Rannikko A., and Huhtaniemi I. Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis. Biol. Reprod. 58 (1998) 116-123
    • (1998) Biol. Reprod. , vol.58 , pp. 116-123
    • El Gehani, F.1    Zhang, F.P.2    Pakarinen, P.3    Rannikko, A.4    Huhtaniemi, I.5
  • 21
    • 0020533647 scopus 로고
    • Evidence for a defective seminiferous tubule barrier in testes of Tfm and Sxr mice
    • Fritz I.B., Lyon M.F., and Setchell B.P. Evidence for a defective seminiferous tubule barrier in testes of Tfm and Sxr mice. J. Reprod. Fertil. 67 (1983) 359-363
    • (1983) J. Reprod. Fertil. , vol.67 , pp. 359-363
    • Fritz, I.B.1    Lyon, M.F.2    Setchell, B.P.3
  • 23
    • 33646888691 scopus 로고    scopus 로고
    • Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein
    • Ghyselinck N.B., Vernet N., Dennefeld C., Giese N., Nau H., Chambon P., Viville S., and Mark M. Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein. Dev. Dyn. 235 (2006) 1608-1622
    • (2006) Dev. Dyn. , vol.235 , pp. 1608-1622
    • Ghyselinck, N.B.1    Vernet, N.2    Dennefeld, C.3    Giese, N.4    Nau, H.5    Chambon, P.6    Viville, S.7    Mark, M.8
  • 25
    • 84995867043 scopus 로고
    • The spermatogenic and secretory function of the gonads of hypophysectomised adult rats treated with pituitary FSH and LH
    • Greep R.O., and Fevold H. The spermatogenic and secretory function of the gonads of hypophysectomised adult rats treated with pituitary FSH and LH. Endocrinology 21 (1937) 611-619
    • (1937) Endocrinology , vol.21 , pp. 611-619
    • Greep, R.O.1    Fevold, H.2
  • 26
    • 0029417468 scopus 로고
    • Morphological studies on the origin of adult-type Leydig cells in rat testis
    • Haider S.G., Laue D., Schwochau G., and Hilscher B. Morphological studies on the origin of adult-type Leydig cells in rat testis. Ital. J. Anat. Embryol. 100 Suppl. 1 (1995) 535-541
    • (1995) Ital. J. Anat. Embryol. , vol.100 , Issue.SUPPL. 1 , pp. 535-541
    • Haider, S.G.1    Laue, D.2    Schwochau, G.3    Hilscher, B.4
  • 27
    • 0032132550 scopus 로고    scopus 로고
    • Ultracytochemistry of 3beta-hydroxysteroid dehydrogenase in Leydig cell precursors and vascular endothelial cells of the postnatal rat testis
    • Haider S.G., and Servos G. Ultracytochemistry of 3beta-hydroxysteroid dehydrogenase in Leydig cell precursors and vascular endothelial cells of the postnatal rat testis. Anat. Embryol. (Berl) 198 (1998) 101-110
    • (1998) Anat. Embryol. (Berl) , vol.198 , pp. 101-110
    • Haider, S.G.1    Servos, G.2
  • 29
    • 0037318477 scopus 로고    scopus 로고
    • Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone
    • Haywood M., Spaliviero J., Jimemez M., King N.J., Handelsman D.J., and Allan C.M. Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology 144 (2003) 509-517
    • (2003) Endocrinology , vol.144 , pp. 509-517
    • Haywood, M.1    Spaliviero, J.2    Jimemez, M.3    King, N.J.4    Handelsman, D.J.5    Allan, C.M.6
  • 30
    • 0036377906 scopus 로고    scopus 로고
    • The expression of the follicle-stimulating hormone receptor in spermatogenesis
    • Heckert L.L., and Griswold M.D. The expression of the follicle-stimulating hormone receptor in spermatogenesis. Recent Prog. Horm. Res. 57 (2002) 129-148
    • (2002) Recent Prog. Horm. Res. , vol.57 , pp. 129-148
    • Heckert, L.L.1    Griswold, M.D.2
  • 31
    • 0020424631 scopus 로고
    • Histopathology of undescended testes
    • Hedinger E. Histopathology of undescended testes. Eur. J. Pediatr. 139 (1982) 266-271
    • (1982) Eur. J. Pediatr. , vol.139 , pp. 266-271
    • Hedinger, E.1
  • 32
    • 0842301556 scopus 로고    scopus 로고
    • Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids
    • Holdcraft R.W., and Braun R.E. Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development 131 (2004) 459-467
    • (2004) Development , vol.131 , pp. 459-467
    • Holdcraft, R.W.1    Braun, R.E.2
  • 33
    • 33745877197 scopus 로고    scopus 로고
    • Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice
    • Huhtaniemi I. Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice. Mol. Cell Endocrinol. 254-255 (2006) 84-90
    • (2006) Mol. Cell Endocrinol. , vol.254-255 , pp. 84-90
    • Huhtaniemi, I.1
  • 34
    • 24644461526 scopus 로고    scopus 로고
    • Mutations in human gonadotropin and gonadotropin-receptor genes
    • Huhtaniemi I.T., and Themmen A.P. Mutations in human gonadotropin and gonadotropin-receptor genes. Endocrine 26 (2005) 207-217
    • (2005) Endocrine , vol.26 , pp. 207-217
    • Huhtaniemi, I.T.1    Themmen, A.P.2
  • 35
    • 0345827710 scopus 로고    scopus 로고
    • Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse
    • Johnston H., Baker P.J., Abel M., Charlton H.M., Jackson G., Fleming L., Kumar T.R., and O'Shaughnessy P.J. Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology 145 (2004) 318-329
    • (2004) Endocrinology , vol.145 , pp. 318-329
    • Johnston, H.1    Baker, P.J.2    Abel, M.3    Charlton, H.M.4    Jackson, G.5    Fleming, L.6    Kumar, T.R.7    O'Shaughnessy, P.J.8
  • 36
    • 34547589135 scopus 로고    scopus 로고
    • Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis
    • Johnston H., King P.J., and O'Shaughnessy P.J. Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis. Reproduction 133 (2007) 1181-1187
    • (2007) Reproduction , vol.133 , pp. 1181-1187
    • Johnston, H.1    King, P.J.2    O'Shaughnessy, P.J.3
  • 37
    • 0032533649 scopus 로고    scopus 로고
    • Sertoli cells of the mouse testis originate from the coelomic epithelium
    • Karl J., and Capel B. Sertoli cells of the mouse testis originate from the coelomic epithelium. Dev. Biol. 203 (1998) 323-333
    • (1998) Dev. Biol. , vol.203 , pp. 323-333
    • Karl, J.1    Capel, B.2
  • 39
    • 0021826754 scopus 로고
    • Follicle-stimulating hormone induction of Leydig cell maturation
    • Kerr J.B., and Sharpe R.M. Follicle-stimulating hormone induction of Leydig cell maturation. Endocrinology 116 (1985) 2592-2604
    • (1985) Endocrinology , vol.116 , pp. 2592-2604
    • Kerr, J.B.1    Sharpe, R.M.2
  • 40
    • 2342517388 scopus 로고    scopus 로고
    • Molecular and genetic regulation of testis descent and external genitalia development
    • Klonisch T., Fowler P.A., and Hombach-Klonisch S. Molecular and genetic regulation of testis descent and external genitalia development. Dev. Biol. 270 (2004) 1-18
    • (2004) Dev. Biol. , vol.270 , pp. 1-18
    • Klonisch, T.1    Fowler, P.A.2    Hombach-Klonisch, S.3
  • 41
    • 0031054284 scopus 로고    scopus 로고
    • Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
    • Kumar T.R., Wang Y., Lu N., and Matzuk M.M. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat. Genet. 15 (1997) 201-204
    • (1997) Nat. Genet. , vol.15 , pp. 201-204
    • Kumar, T.R.1    Wang, Y.2    Lu, N.3    Matzuk, M.M.4
  • 42
    • 0036345561 scopus 로고    scopus 로고
    • FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia
    • Layman L.C., Porto A.L., Xie J., da Motta L.A., da Motta L.D., Weiser W., and Sluss P.M. FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia. J. Clin. Endocrinol. Metab. 87 (2002) 3702-3707
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3702-3707
    • Layman, L.C.1    Porto, A.L.2    Xie, J.3    da Motta, L.A.4    da Motta, L.D.5    Weiser, W.6    Sluss, P.M.7
  • 43
    • 0031712880 scopus 로고    scopus 로고
    • Follitropin (FSH) deficiency in an infertile male due to FSHbeta gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations
    • Lindstedt G., Nystrom E., Matthews C., Ernest I., Janson P.O., and Chatterjee K. Follitropin (FSH) deficiency in an infertile male due to FSHbeta gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations. Clin. Chem. Lab. Med. 36 (1998) 663-665
    • (1998) Clin. Chem. Lab. Med. , vol.36 , pp. 663-665
    • Lindstedt, G.1    Nystrom, E.2    Matthews, C.3    Ernest, I.4    Janson, P.O.5    Chatterjee, K.6
  • 44
    • 0036327168 scopus 로고    scopus 로고
    • Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice
    • Lecureuil C., Fontaine I., Crepieux P., and Guillou F. Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice. Genesis 33 (2002) 114-118
    • (2002) Genesis , vol.33 , pp. 114-118
    • Lecureuil, C.1    Fontaine, I.2    Crepieux, P.3    Guillou, F.4
  • 45
    • 0030296865 scopus 로고    scopus 로고
    • Pem: a testosterone-regulated and LH-regulated homeobox gene expressed in mouse sertoli cells and epididymis
    • Lindsey J.S., and Wilkinson M.F. Pem: a testosterone-regulated and LH-regulated homeobox gene expressed in mouse sertoli cells and epididymis. Dev. Biol. 179 (1996) 471-484
    • (1996) Dev. Biol. , vol.179 , pp. 471-484
    • Lindsey, J.S.1    Wilkinson, M.F.2
  • 47
    • 0014955076 scopus 로고
    • X-linked gene for testicular feminization in the mouse
    • Lyon M.F., and Hawkes S.G. X-linked gene for testicular feminization in the mouse. Nature 227 (1970) 1217-1219
    • (1970) Nature , vol.227 , pp. 1217-1219
    • Lyon, M.F.1    Hawkes, S.G.2
  • 48
    • 10344230978 scopus 로고    scopus 로고
    • Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility
    • Ma X., Dong Y., Matzuk M.M., and Kumar T.R. Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 17294-17299
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 17294-17299
    • Ma, X.1    Dong, Y.2    Matzuk, M.M.3    Kumar, T.R.4
  • 50
    • 0029084589 scopus 로고
    • The effects of recombinant follicle-stimulating hormone on the restoration of spermatogenesis in the gonadotropin-releasing hormone-immunized adult rat
    • McLachlan R.I., Wreford N.G., de Kretser D.M., and Robertson D.M. The effects of recombinant follicle-stimulating hormone on the restoration of spermatogenesis in the gonadotropin-releasing hormone-immunized adult rat. Endocrinology 136 (1995) 4035-4043
    • (1995) Endocrinology , vol.136 , pp. 4035-4043
    • McLachlan, R.I.1    Wreford, N.G.2    de Kretser, D.M.3    Robertson, D.M.4
  • 52
    • 0027517179 scopus 로고
    • Junction-related Sertoli cell cytoskeleton in testosterone-treated hypophysectomized rats
    • Muffly K.E., Nazian S.J., and Cameron D.F. Junction-related Sertoli cell cytoskeleton in testosterone-treated hypophysectomized rats. Biol. Reprod. 49 (1993) 1122-1132
    • (1993) Biol. Reprod. , vol.49 , pp. 1122-1132
    • Muffly, K.E.1    Nazian, S.J.2    Cameron, D.F.3
  • 53
    • 0027968766 scopus 로고
    • Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse
    • Murphy L., Jeffcoate I.A., and O'Shaughnessy P.J. Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse. Endocrinology 135 (1994) 1372-1377
    • (1994) Endocrinology , vol.135 , pp. 1372-1377
    • Murphy, L.1    Jeffcoate, I.A.2    O'Shaughnessy, P.J.3
  • 54
    • 0034663434 scopus 로고    scopus 로고
    • A molecular basis for estrogen-induced cryptorchidism
    • Nef S., Shipman T., and Parada L.F. A molecular basis for estrogen-induced cryptorchidism. Dev. Biol. 224 (2000) 354-361
    • (2000) Dev. Biol. , vol.224 , pp. 354-361
    • Nef, S.1    Shipman, T.2    Parada, L.F.3
  • 55
    • 34250823708 scopus 로고    scopus 로고
    • Altered expression of genes involved in regulation of vitamin a metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis
    • O'Shaughnessy P.J., Abel M., Charlton H.M., Hu B., Johnston H., and Baker P.J. Altered expression of genes involved in regulation of vitamin a metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148 (2007) 2914-2924
    • (2007) Endocrinology , vol.148 , pp. 2914-2924
    • O'Shaughnessy, P.J.1    Abel, M.2    Charlton, H.M.3    Hu, B.4    Johnston, H.5    Baker, P.J.6
  • 56
    • 0031796489 scopus 로고    scopus 로고
    • Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function
    • O'Shaughnessy P.J., Baker P., Sohnius U., Haavisto A.-M., Charlton H.M., and Huhtaniemi I. Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function. Endocrinology 139 (1998) 1141-1146
    • (1998) Endocrinology , vol.139 , pp. 1141-1146
    • O'Shaughnessy, P.J.1    Baker, P.2    Sohnius, U.3    Haavisto, A.-M.4    Charlton, H.M.5    Huhtaniemi, I.6
  • 57
    • 0026487120 scopus 로고
    • Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse
    • O'Shaughnessy P.J., Bennett M.K., Scott I.S., and Charlton H.M. Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse. J. Endocrinol. 135 (1992) 517-525
    • (1992) J. Endocrinol. , vol.135 , pp. 517-525
    • O'Shaughnessy, P.J.1    Bennett, M.K.2    Scott, I.S.3    Charlton, H.M.4
  • 58
    • 0041758465 scopus 로고    scopus 로고
    • Adrenocoricotrophic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis
    • O'Shaughnessy P.J., Fleming L.M., Jackson G., Hochgeschwender U., Reed P., and Baker P.J. Adrenocoricotrophic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. Endocrinology 144 (2003) 3279-3284
    • (2003) Endocrinology , vol.144 , pp. 3279-3284
    • O'Shaughnessy, P.J.1    Fleming, L.M.2    Jackson, G.3    Hochgeschwender, U.4    Reed, P.5    Baker, P.J.6
  • 59
    • 0036712830 scopus 로고    scopus 로고
    • Failure of normal adult Leydig cell development in androgen-receptor-deficient mice
    • O'Shaughnessy P.J., Johnston H., Willerton L., and Baker P.J. Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. J. Cell Sci. 115 (2002) 3491-3496
    • (2002) J. Cell Sci. , vol.115 , pp. 3491-3496
    • O'Shaughnessy, P.J.1    Johnston, H.2    Willerton, L.3    Baker, P.J.4
  • 60
    • 45249107787 scopus 로고    scopus 로고
    • Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis
    • O'Shaughnessy P.J., Morris I.D., and Baker P.J. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. Reproduction 135 (2008) 851-858
    • (2008) Reproduction , vol.135 , pp. 851-858
    • O'Shaughnessy, P.J.1    Morris, I.D.2    Baker, P.J.3
  • 61
    • 0036828229 scopus 로고    scopus 로고
    • Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice
    • Pakarinen P., Kimura S., El Gehani F., Pelliniemi L.J., and Huhtaniemi I. Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice. Endocrinology 143 (2002) 4477-4482
    • (2002) Endocrinology , vol.143 , pp. 4477-4482
    • Pakarinen, P.1    Kimura, S.2    El Gehani, F.3    Pelliniemi, L.J.4    Huhtaniemi, I.5
  • 62
    • 0025777399 scopus 로고
    • In situ analysis of fetal, prepuberal and adult XX/Xy chimeric mouse testes-sertoli cells are predominantly, but not exclusively, XY
    • Palmer S.J., and Burgoyne P.S. In situ analysis of fetal, prepuberal and adult XX/Xy chimeric mouse testes-sertoli cells are predominantly, but not exclusively, XY. Development 112 (1991) 265-268
    • (1991) Development , vol.112 , pp. 265-268
    • Palmer, S.J.1    Burgoyne, P.S.2
  • 63
    • 34547132553 scopus 로고    scopus 로고
    • Distinct roles for Steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development
    • Park S.Y., Tong M., and Jameson J.L. Distinct roles for Steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development. Endocrinology 148 (2007) 3704-3710
    • (2007) Endocrinology , vol.148 , pp. 3704-3710
    • Park, S.Y.1    Tong, M.2    Jameson, J.L.3
  • 64
    • 0034758841 scopus 로고    scopus 로고
    • A developmental study of the desert hedgehog-null mouse testis
    • Pierucci-Alves F., Clark A.M., and Russell L.D. A developmental study of the desert hedgehog-null mouse testis. Biol. Reprod. 65 (2001) 1392-1402
    • (2001) Biol. Reprod. , vol.65 , pp. 1392-1402
    • Pierucci-Alves, F.1    Clark, A.M.2    Russell, L.D.3
  • 65
    • 0032508059 scopus 로고    scopus 로고
    • Male hypogonadism due to a mutation in the gene for the beta-subunit of follicle-stimulating hormone
    • Phillip M., Arbelle J.E., Segev Y., and Parvari R. Male hypogonadism due to a mutation in the gene for the beta-subunit of follicle-stimulating hormone. N. Eng. J. Med. 338 (1998) 1729-1732
    • (1998) N. Eng. J. Med. , vol.338 , pp. 1729-1732
    • Phillip, M.1    Arbelle, J.E.2    Segev, Y.3    Parvari, R.4
  • 66
    • 0027367277 scopus 로고
    • Recombinant human follicle-stimulating hormone is capable of exerting a biological effect in the adult hypophysectomized rat by reducing the numbers of degenerating germ cells
    • Russell L.D., Corbin T.J., Borg K.E., De Franca L.R., Grasso P., and Bartke A. Recombinant human follicle-stimulating hormone is capable of exerting a biological effect in the adult hypophysectomized rat by reducing the numbers of degenerating germ cells. Endocrinology 133 (1993) 2062-2070
    • (1993) Endocrinology , vol.133 , pp. 2062-2070
    • Russell, L.D.1    Corbin, T.J.2    Borg, K.E.3    De Franca, L.R.4    Grasso, P.5    Bartke, A.6
  • 67
    • 0028961947 scopus 로고
    • Characteristics of mitotic cells in developing and adult testes with observations on cell lineages
    • Russell L.D., De Franca L.R., Hess R., and Cooke P. Characteristics of mitotic cells in developing and adult testes with observations on cell lineages. Tissue Cell 27 (1995) 105-128
    • (1995) Tissue Cell , vol.27 , pp. 105-128
    • Russell, L.D.1    De Franca, L.R.2    Hess, R.3    Cooke, P.4
  • 68
    • 8344229906 scopus 로고    scopus 로고
    • Follicle-stimulating hormone induced changes in gene expression of murine testis
    • Sadate-Ngatchou P.I., Pouchnik D.J., and Griswold M.D. Follicle-stimulating hormone induced changes in gene expression of murine testis. Mol. Endocrinol. 18 (2004) 2805-2816
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2805-2816
    • Sadate-Ngatchou, P.I.1    Pouchnik, D.J.2    Griswold, M.D.3
  • 69
    • 0842290984 scopus 로고    scopus 로고
    • Identification of testosterone-regulated genes in testes of hypogonadal mice using oligonucleotide microarray
    • Sadate-Ngatchou P.I., Pouchnik D.J., and Griswold M.D. Identification of testosterone-regulated genes in testes of hypogonadal mice using oligonucleotide microarray. Mol. Endocrinol. 18 (2004) 422-433
    • (2004) Mol. Endocrinol. , vol.18 , pp. 422-433
    • Sadate-Ngatchou, P.I.1    Pouchnik, D.J.2    Griswold, M.D.3
  • 70
    • 45149093155 scopus 로고    scopus 로고
    • Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    • Sekido R., and Lovell-Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 453 (2008) 930-934
    • (2008) Nature , vol.453 , pp. 930-934
    • Sekido, R.1    Lovell-Badge, R.2
  • 71
    • 0028876068 scopus 로고
    • Induction of spermatogenesis by androgens in gonadotropin-deficient (Hpg) Mice
    • Singh J., Oneill C., and Handelsman D.J. Induction of spermatogenesis by androgens in gonadotropin-deficient (Hpg) Mice. Endocrinology 136 (1995) 5311-5321
    • (1995) Endocrinology , vol.136 , pp. 5311-5321
    • Singh, J.1    Oneill, C.2    Handelsman, D.J.3
  • 72
    • 84940140720 scopus 로고
    • Experimental evidence regarding the role of the anterior pituitary in development and regulation of the genital system
    • Smith P.E., and Engle E.T. Experimental evidence regarding the role of the anterior pituitary in development and regulation of the genital system. Am. J. Anat. 40 (1927) 159-168
    • (1927) Am. J. Anat. , vol.40 , pp. 159-168
    • Smith, P.E.1    Engle, E.T.2
  • 73
    • 1842376911 scopus 로고    scopus 로고
    • Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility
    • Tapanainen J.S., Aittomaki K., Min J., Vaskivuo T., and Huhtaniemi I.T. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat. Genet. 15 (1997) 205-206
    • (1997) Nat. Genet. , vol.15 , pp. 205-206
    • Tapanainen, J.S.1    Aittomaki, K.2    Min, J.3    Vaskivuo, T.4    Huhtaniemi, I.T.5
  • 74
    • 18844407557 scopus 로고    scopus 로고
    • The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total (ARKO) or Sertoli cell-selective (SCARKO) ablation of the androgen receptor
    • Tan K.A., De Gendt K., Atanassova N., Walker M., Sharpe R.M., Saunders P.T., Denolet E., and Verhoeven G. The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total (ARKO) or Sertoli cell-selective (SCARKO) ablation of the androgen receptor. Endocrinology 146 (2005) 2674-2683
    • (2005) Endocrinology , vol.146 , pp. 2674-2683
    • Tan, K.A.1    De Gendt, K.2    Atanassova, N.3    Walker, M.4    Sharpe, R.M.5    Saunders, P.T.6    Denolet, E.7    Verhoeven, G.8
  • 76
    • 67349209265 scopus 로고    scopus 로고
    • Dynamics of Leydig cell regeneration after EDS: a model for postnatal Leydig cell development
    • Payne A.H., and Hardy M.P. (Eds), Humana Press, Totowa
    • Teerds K.J., and Rijntjes E. Dynamics of Leydig cell regeneration after EDS: a model for postnatal Leydig cell development. In: Payne A.H., and Hardy M.P. (Eds). The Leydig Cell in Health and Disease (2007), Humana Press, Totowa 91-116
    • (2007) The Leydig Cell in Health and Disease , pp. 91-116
    • Teerds, K.J.1    Rijntjes, E.2
  • 78
    • 0033711033 scopus 로고    scopus 로고
    • Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function
    • Themmen A.P.N., and Huhtaniemi I.T. Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr. Rev. 21 (2000) 551-583
    • (2000) Endocr. Rev. , vol.21 , pp. 551-583
    • Themmen, A.P.N.1    Huhtaniemi, I.T.2
  • 81
    • 0025996822 scopus 로고
    • Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats
    • Vihko K.K., LaPolt P.S., Nishimori K., and Hsueh A.J. Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats. Endocrinology 129 (1991) 1926-1932
    • (1991) Endocrinology , vol.129 , pp. 1926-1932
    • Vihko, K.K.1    LaPolt, P.S.2    Nishimori, K.3    Hsueh, A.J.4
  • 82
    • 0242361425 scopus 로고
    • The physiologic maintenance of male sex glands: the effect of androtin on hypophysectomized rats
    • Walsh E.L., Cuyler W.K., and McCullagh D.R. The physiologic maintenance of male sex glands: the effect of androtin on hypophysectomized rats. Am. J. Physiol. 107 (1934) 508-518
    • (1934) Am. J. Physiol. , vol.107 , pp. 508-518
    • Walsh, E.L.1    Cuyler, W.K.2    McCullagh, D.R.3
  • 83
    • 0026335545 scopus 로고
    • Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone
    • Weiss J., Axelrod L., Whitcomb R.W., Harris P.E., Crowley W.F., and Jameson J.L. Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. N. Eng. J. Med. 326 (1992) 179-183
    • (1992) N. Eng. J. Med. , vol.326 , pp. 179-183
    • Weiss, J.1    Axelrod, L.2    Whitcomb, R.W.3    Harris, P.E.4    Crowley, W.F.5    Jameson, J.L.6
  • 84
    • 0036606827 scopus 로고    scopus 로고
    • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis
    • Yao H.H., Whoriskey W., and Capel B. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev. 16 (2002) 1433-1440
    • (2002) Genes Dev. , vol.16 , pp. 1433-1440
    • Yao, H.H.1    Whoriskey, W.2    Capel, B.3
  • 85
    • 0032467583 scopus 로고    scopus 로고
    • Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats
    • You L., and Sar M. Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats. Endocrine 9 (1998) 253-261
    • (1998) Endocrine , vol.9 , pp. 253-261
    • You, L.1    Sar, M.2
  • 86
    • 0035133266 scopus 로고    scopus 로고
    • Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice
    • Zhang F.P., Poutanen M., Wilbertz J., and Huhtaniemi I. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol. Endocrinol. 15 (2001) 172-183
    • (2001) Mol. Endocrinol. , vol.15 , pp. 172-183
    • Zhang, F.P.1    Poutanen, M.2    Wilbertz, J.3    Huhtaniemi, I.4
  • 87
    • 1442299095 scopus 로고    scopus 로고
    • Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice
    • Zhang F.P., Pakarainen T., Zhu F., Poutanen M., and Huhtaniemi I. Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice. Endocrinology 145 (2004) 1453-1463
    • (2004) Endocrinology , vol.145 , pp. 1453-1463
    • Zhang, F.P.1    Pakarainen, T.2    Zhu, F.3    Poutanen, M.4    Huhtaniemi, I.5
  • 88
    • 15544382569 scopus 로고    scopus 로고
    • Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis
    • Zhou Q., Shima J.E., Nie R., Friel P.J., and Griswold M.D. Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis. Biol. Reprod. 72 (2005) 1010-1019
    • (2005) Biol. Reprod. , vol.72 , pp. 1010-1019
    • Zhou, Q.1    Shima, J.E.2    Nie, R.3    Friel, P.J.4    Griswold, M.D.5


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