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Volumn 86, Issue 1, 2013, Pages 129-136

Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms

Author keywords

Anti diabetic mechanisms; Brown algae; Marine polyphenols; Phlorotannins

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 6,6' BIECKOL; 7 PHLOROECKOL; ALPHA GLUCOSIDASE; AMYLASE; ANTIDIABETIC AGENT; DIECKOL; DIOXINODEHYDROECKOL; DIPHLORETHOHYDROXYCARMALOL; ECKOL; FUCODIPHLOROETHOL G; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE TRANSPORTER 4; INSULIN; METFORMIN; NITRIC OXIDE; OCTAPHLORETHOL A; PEROXYNITRITE; PHLOROFUCOFUROECKOL A; PHLOROGLUCINOL; PHLOROTANNIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); POLYPHENOL; POLYPHENOL DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84876375175     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2013.02.013     Document Type: Review
Times cited : (210)

References (51)
  • 1
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • P. Zimmet, K. Alberti, and J. Shaw Global and societal implications of the diabetes epidemic Nature 414 2001 782 787
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.2    Shaw, J.3
  • 2
    • 0031853586 scopus 로고    scopus 로고
    • Postprandial hyperglycemia and α-glucosidase inhibitors
    • A.D. Baron Postprandial hyperglycemia and α-glucosidase inhibitors Diabetes Res Clin Pract 40 1998 S51 S55
    • (1998) Diabetes Res Clin Pract , vol.40
    • Baron, A.D.1
  • 3
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • R.A. DeFronzo Pharmacologic therapy for type 2 diabetes mellitus Ann Intern Med 131 1999 281 303
    • (1999) Ann Intern Med , vol.131 , pp. 281-303
    • Defronzo, R.A.1
  • 4
    • 31344459794 scopus 로고    scopus 로고
    • Effects of Okchun-San, a herbal formulation, on blood glucose levels and body weight in a model of type 2 diabetes
    • M.S. Chang, M.S. Oh, D.R. Kim, K.J. Jung, S. Park, and S.B. Choi Effects of Okchun-San, a herbal formulation, on blood glucose levels and body weight in a model of type 2 diabetes J Ethnopharmacol 103 2006 491 495
    • (2006) J Ethnopharmacol , vol.103 , pp. 491-495
    • Chang, M.S.1    Oh, M.S.2    Kim, D.R.3    Jung, K.J.4    Park, S.5    Choi, S.B.6
  • 5
    • 34547783227 scopus 로고    scopus 로고
    • The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice
    • U.J. Jung, N.I. Baek, H.G. Chung, M.H. Bang, J.S. Yoo, and T.S. Jeong The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice Food Chem Toxicol 45 2007 2022 2029
    • (2007) Food Chem Toxicol , vol.45 , pp. 2022-2029
    • Jung, U.J.1    Baek, N.I.2    Chung, H.G.3    Bang, M.H.4    Yoo, J.S.5    Jeong, T.S.6
  • 6
    • 67449116102 scopus 로고    scopus 로고
    • Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice
    • S.J. Heo, J.Y. Hwang, J.I. Choi, J.S. Han, H.J. Kim, and Y.J. Jeon Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice Eur J Pharmacol 615 2009 252 256
    • (2009) Eur J Pharmacol , vol.615 , pp. 252-256
    • Heo, S.J.1    Hwang, J.Y.2    Choi, J.I.3    Han, J.S.4    Kim, H.J.5    Jeon, Y.J.6
  • 7
    • 77956341108 scopus 로고    scopus 로고
    • Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro, and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice
    • S.H. Lee, M.H. Park, S.J. Heo, S.M. Kang, S.C. KO, and J.S. Han Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro, and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice Food Chem Toxicol 48 2010 2633 2637
    • (2010) Food Chem Toxicol , vol.48 , pp. 2633-2637
    • Lee, S.H.1    Park, M.H.2    Heo, S.J.3    Kang, S.M.4    Ko, S.C.5    Han, J.S.6
  • 8
    • 76549100097 scopus 로고    scopus 로고
    • Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells
    • S.H. Lee, J.S. Han, S.J. Heo, J.Y. Hwang, and Y.J. Jeon Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells Toxicol In Vitro 24 2010 375 381
    • (2010) Toxicol in Vitro , vol.24 , pp. 375-381
    • Lee, S.H.1    Han, J.S.2    Heo, S.J.3    Hwang, J.Y.4    Jeon, Y.J.5
  • 9
    • 77952877895 scopus 로고    scopus 로고
    • Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells
    • S.J. Heo, J.Y. Hwang, J.I. Choi, S.H. Lee, P.J. Park, and D.H. Kang Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells Food Chem Toxicol 48 2009 1448 1454
    • (2009) Food Chem Toxicol , vol.48 , pp. 1448-1454
    • Heo, S.J.1    Hwang, J.Y.2    Choi, J.I.3    Lee, S.H.4    Park, P.J.5    Kang, D.H.6
  • 10
    • 80051962940 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase 1B and α-glucosidase inhibitory phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis
    • H.E. Moon, M.N. Islam, B.R. Ahn, S.S. Chowdhury, H.S. Sohn, and H.A. Jung Protein tyrosine phosphatase 1B and α-glucosidase inhibitory phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis Biosci Biotechnol Biochem 75 2011 1472 1480
    • (2011) Biosci Biotechnol Biochem , vol.75 , pp. 1472-1480
    • Moon, H.E.1    Islam, M.N.2    Ahn, B.R.3    Chowdhury, S.S.4    Sohn, H.S.5    Jung, H.A.6
  • 11
    • 84863259840 scopus 로고    scopus 로고
    • Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus
    • S.H. Lee, K.H. Min, J.S. Han, D.H. Lee, D.B. Park, and W.K. Jung Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus Food Chem Toxicol 50 2012 575 582
    • (2012) Food Chem Toxicol , vol.50 , pp. 575-582
    • Lee, S.H.1    Min, K.H.2    Han, J.S.3    Lee, D.H.4    Park, D.B.5    Jung, W.K.6
  • 12
    • 79960554259 scopus 로고    scopus 로고
    • Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice
    • K.H. Min, H.J. Kim, Y.J. Jeon, and J.S. Han Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice Diabetes Res Clin Pract 93 2011 70 76
    • (2011) Diabetes Res Clin Pract , vol.93 , pp. 70-76
    • Min, K.H.1    Kim, H.J.2    Jeon, Y.J.3    Han, J.S.4
  • 13
    • 20444403434 scopus 로고    scopus 로고
    • Marine Pharmacology in 2001-2002: Marine compounds with antithelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; Affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action
    • A.M.S. Mayer, and M.T. Hamann Marine Pharmacology in 2001-2002: marine compounds with antithelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action Comp Biochem Physiol C Toxicol Pharmacol 140 2005 265 286
    • (2005) Comp Biochem Physiol C Toxicol Pharmacol , vol.140 , pp. 265-286
    • Mayer, A.M.S.1    Hamann, M.T.2
  • 14
    • 48649084024 scopus 로고    scopus 로고
    • Identification of chemical structure and free radical scavenging activity of diphlorethohydroxycarmalol isolated from a brown alga, Ishige okamurae
    • S.J. Heo, J.P. Kim, W.K. Jung, N.H. Lee, H.S. Kang, and E.M. Jun Identification of chemical structure and free radical scavenging activity of diphlorethohydroxycarmalol isolated from a brown alga, Ishige okamurae J Microbiol Biotechnol 18 2008 676 681
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 676-681
    • Heo, S.J.1    Kim, J.P.2    Jung, W.K.3    Lee, N.H.4    Kang, H.S.5    Jun, E.M.6
  • 15
    • 67349194659 scopus 로고    scopus 로고
    • Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells
    • C.S. Kong, J.A. Kim, N.Y. Yoon, and S.K. Kim Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells Food Chem Toxicol 47 2009 1653 1658
    • (2009) Food Chem Toxicol , vol.47 , pp. 1653-1658
    • Kong, C.S.1    Kim, J.A.2    Yoon, N.Y.3    Kim, S.K.4
  • 16
    • 0028119537 scopus 로고
    • Plant polyphenols (vegetable tannins): Gallic acid metabolism
    • E. Haslam, and Y. Cai Plant polyphenols (vegetable tannins): gallic acid metabolism Nat Prod Rep 11 1994 41 66
    • (1994) Nat Prod Rep , vol.11 , pp. 41-66
    • Haslam, E.1    Cai, Y.2
  • 17
    • 33746589549 scopus 로고    scopus 로고
    • Phloroglucinol compounds of natural origin
    • I.P. Singh, and S.B. Bharate Phloroglucinol compounds of natural origin Nat Prod Rep 23 2006 558 591
    • (2006) Nat Prod Rep , vol.23 , pp. 558-591
    • Singh, I.P.1    Bharate, S.B.2
  • 18
    • 0036811712 scopus 로고    scopus 로고
    • Marine tannins: The importance of a mechanistic framework for predicting ecological roles
    • T.M. Arnold, and N.M. Targett Marine tannins: the importance of a mechanistic framework for predicting ecological roles J Chem Ecol 28 2002 1919 1934
    • (2002) J Chem Ecol , vol.28 , pp. 1919-1934
    • Arnold, T.M.1    Targett, N.M.2
  • 19
    • 0000464965 scopus 로고
    • Phlorotannins, brown algal polyphenols
    • J.A. Hellebust, J.S. Craigie, Cambridge University Press New York
    • M.A. Ragan, and K.W. Glombitza Phlorotannins, brown algal polyphenols J.A. Hellebust, J.S. Craigie, Progress in Phycological Research 1986 Cambridge University Press New York 129 241
    • (1986) Progress in Phycological Research , pp. 129-241
    • Ragan, M.A.1    Glombitza, K.W.2
  • 20
    • 68949196471 scopus 로고    scopus 로고
    • α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava
    • S.H. Lee, Y. Li, F. Karadeniz, M.M. Kim, and S.K. Kim α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava J Sci Food Agric 89 2009 1552 1558
    • (2009) J Sci Food Agric , vol.89 , pp. 1552-1558
    • Lee, S.H.1    Li, Y.2    Karadeniz, F.3    Kim, M.M.4    Kim, S.K.5
  • 21
    • 0016749864 scopus 로고
    • Carbohydrate digestion and absorption role of small intestine
    • D.M. Gray Carbohydrate digestion and absorption role of small intestine N Engl J Med 29 1995 1225 1230
    • (1995) N Engl J Med , vol.29 , pp. 1225-1230
    • Gray, D.M.1
  • 22
    • 13644263258 scopus 로고    scopus 로고
    • Oral antidiabetic agents. Current role in type 2 diabetes mellitus
    • A.J. Krentz, and C.J. Bailey Oral antidiabetic agents. Current role in type 2 diabetes mellitus Drugs 65 2005 385 411
    • (2005) Drugs , vol.65 , pp. 385-411
    • Krentz, A.J.1    Bailey, C.J.2
  • 25
    • 0000925607 scopus 로고
    • The inhibition of α-amylase by tea polyphenols
    • Y. Hara, and M. Honda The inhibition of α-amylase by tea polyphenols Agric Biol Chem 54 1990 1939 1945
    • (1990) Agric Biol Chem , vol.54 , pp. 1939-1945
    • Hara, Y.1    Honda, M.2
  • 26
    • 78751568044 scopus 로고    scopus 로고
    • Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae
    • F. Nwosu, J. Morris, V.A. Lund, D. Stewart, H.A. Ross, and G.J. McDougall Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae Food Chem 126 2011 1006 1012
    • (2011) Food Chem , vol.126 , pp. 1006-1012
    • Nwosu, F.1    Morris, J.2    Lund, V.A.3    Stewart, D.4    Ross, H.A.5    McDougall, G.J.6
  • 28
    • 56049105599 scopus 로고    scopus 로고
    • Potent α-glucosidase inhibitors purified from the red alga Grateloupia elliptica
    • K.Y. Kim, K.A. Nam, H. Kurihara, and S.M. Kim Potent α-glucosidase inhibitors purified from the red alga Grateloupia elliptica Phytochemistry 69 2008 2820 2825
    • (2008) Phytochemistry , vol.69 , pp. 2820-2825
    • Kim, K.Y.1    Nam, K.A.2    Kurihara, H.3    Kim, S.M.4
  • 29
    • 80054681732 scopus 로고    scopus 로고
    • Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo
    • M.C. Roy, R. Anguenot, C. Fillion, M. Beaulieu, J. Berube, and D. Richard Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo Food Res Int 44 2011 3026 3029
    • (2011) Food Res Int , vol.44 , pp. 3026-3029
    • Roy, M.C.1    Anguenot, R.2    Fillion, C.3    Beaulieu, M.4    Berube, J.5    Richard, D.6
  • 30
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • U. Ozcan, E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vailancourt, and R.O. Smith Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 313 2006 1137 1140
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vailancourt, E.5    Smith, R.O.6
  • 32
    • 0037184495 scopus 로고    scopus 로고
    • Molecular understanding of hyperglycemia's adverse effects for diabetic complications
    • M.J. Sheetz, and G.L. King Molecular understanding of hyperglycemia's adverse effects for diabetic complications J Am Med Assoc 288 2002 2579 2588
    • (2002) J Am Med Assoc , vol.288 , pp. 2579-2588
    • Sheetz, M.J.1    King, G.L.2
  • 33
    • 44549084822 scopus 로고    scopus 로고
    • Selective regulation of the perinuclear distribution of glucose transport 4 (GLUT4) by insulin signals in muscle cells
    • C.B. Dugani, V.K. Randhawa, A.W. Cheng, N. Patel, and A. Klip Selective regulation of the perinuclear distribution of glucose transport 4 (GLUT4) by insulin signals in muscle cells Eur J Cell Biol 87 2008 337 351
    • (2008) Eur J Cell Biol , vol.87 , pp. 337-351
    • Dugani, C.B.1    Randhawa, V.K.2    Cheng, A.W.3    Patel, N.4    Klip, A.5
  • 34
    • 0035937107 scopus 로고    scopus 로고
    • Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic
    • J. Harder, J. Bartels, E. Christophers, and J.M. Schroder Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic J Biol Chem 276 2001 5707 5713
    • (2001) J Biol Chem , vol.276 , pp. 5707-5713
    • Harder, J.1    Bartels, J.2    Christophers, E.3    Schroder, J.M.4
  • 35
    • 0037005996 scopus 로고    scopus 로고
    • Current status of defensins and their role in innate and adaptive immunity
    • P.A. Raj, and A.R. Dentino Current status of defensins and their role in innate and adaptive immunity FEMS Microbiol Lett 206 2002 9 18
    • (2002) FEMS Microbiol Lett , vol.206 , pp. 9-18
    • Raj, P.A.1    Dentino, A.R.2
  • 36
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • U. Ozcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, and E. Ozdelen Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 37
    • 6344292389 scopus 로고    scopus 로고
    • Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo role of mitochondrial reactive nitrogen species
    • M.H. Zou, S.S. Kirkpatrick, B.J. Davis, J.S. Nelson, W.G. Wiles IV, and U. Schlattner Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo role of mitochondrial reactive nitrogen species J Biol Chem 279 2004 43940 43951
    • (2004) J Biol Chem , vol.279 , pp. 43940-43951
    • Zou, M.H.1    Kirkpatrick, S.S.2    Davis, B.J.3    Nelson, J.S.4    Wiles, I.V.W.G.5    Schlattner, U.6
  • 38
    • 20044372016 scopus 로고    scopus 로고
    • Troglitazone causes acute mitochondrial membrane depolarization and an AMPK-mediated increase in glucose phosphorylation in muscle cells
    • D. Konrad, A. Rudich, P.J. Bilan, N. Patel, C. Richardson, and L.A. Witters Troglitazone causes acute mitochondrial membrane depolarization and an AMPK-mediated increase in glucose phosphorylation in muscle cells Diabetologia 48 2005 954 956
    • (2005) Diabetologia , vol.48 , pp. 954-956
    • Konrad, D.1    Rudich, A.2    Bilan, P.J.3    Patel, N.4    Richardson, C.5    Witters, L.A.6
  • 39
    • 75049084216 scopus 로고    scopus 로고
    • Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways
    • C. Kang, Y.B. Jin, H. Lee, M. Cha, E. Sohn, and J. Moon Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways Food Chem Toxicol 48 2010 509 516
    • (2010) Food Chem Toxicol , vol.48 , pp. 509-516
    • Kang, C.1    Jin, Y.B.2    Lee, H.3    Cha, M.4    Sohn, E.5    Moon, J.6
  • 41
    • 84859590205 scopus 로고    scopus 로고
    • Octaphlorethol A, a novel phenolic compound isolated from a brown alga, Ishige foliacea, increases glucose transporter 4-mediated glucose uptake in skeletal muscle cells
    • S.H. Lee, S.M. Kang, S.C. Ko, D.H. Lee, and Y.J. Jeon Octaphlorethol A, a novel phenolic compound isolated from a brown alga, Ishige foliacea, increases glucose transporter 4-mediated glucose uptake in skeletal muscle cells Biochem Biophys Res Commun 420 2012 576 581
    • (2012) Biochem Biophys Res Commun , vol.420 , pp. 576-581
    • Lee, S.H.1    Kang, S.M.2    Ko, S.C.3    Lee, D.H.4    Jeon, Y.J.5
  • 42
    • 0038199726 scopus 로고    scopus 로고
    • PTP1B: From the sidelines to the front lines!
    • N.K. Tonks PTP1B: from the sidelines to the front lines! FEBS Lett 546 2003 140 148
    • (2003) FEBS Lett , vol.546 , pp. 140-148
    • Tonks, N.K.1
  • 43
    • 34347260715 scopus 로고    scopus 로고
    • Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B
    • S. Lee, and Q. Wang Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B Med Res Rev 27 2007 553 573
    • (2007) Med Res Rev , vol.27 , pp. 553-573
    • Lee, S.1    Wang, Q.2
  • 44
    • 0027059040 scopus 로고
    • Animal models of non-insulin-dependent diabetes
    • E. Shafrir Animal models of non-insulin-dependent diabetes Diabetes Metab Rev 8 1992 179 208
    • (1992) Diabetes Metab Rev , vol.8 , pp. 179-208
    • Shafrir, E.1
  • 45
    • 0034992273 scopus 로고    scopus 로고
    • Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: Additional evidence for a defect in hepatic glucokinase activity
    • A. Basu, R. Basu, P. Shah, A. Vella, C.M. Johnson, and K.S. Nair Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: Additional evidence for a defect in hepatic glucokinase activity Diabetes 50 2001 1351 1362
    • (2001) Diabetes , vol.50 , pp. 1351-1362
    • Basu, A.1    Basu, R.2    Shah, P.3    Vella, A.4    Johnson, C.M.5    Nair, K.S.6
  • 46
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase
    • C. Postic, M. Shiota, K.D. Niswender, T.L. Jetton, Y. Chen, and J.M. Moates Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase J Biol Chem 274 1999 305 315
    • (1999) J Biol Chem , vol.274 , pp. 305-315
    • Postic, C.1    Shiota, M.2    Niswender, K.D.3    Jetton, T.L.4    Chen, Y.5    Moates, J.M.6
  • 47
    • 0027325424 scopus 로고
    • Recent advances in hepatic glucose-6-phosphate regulation and function
    • R.C. Nordlie, A.M. Bode, and J.D. Foster Recent advances in hepatic glucose-6-phosphate regulation and function Proc Soc Exp Biol Med 203 1993 274 285
    • (1993) Proc Soc Exp Biol Med , vol.203 , pp. 274-285
    • Nordlie, R.C.1    Bode, A.M.2    Foster, J.D.3
  • 48
    • 0031051338 scopus 로고    scopus 로고
    • New knowledge regarding glucose-6-phosphatase gene and protein and their roles in the regulation of glucose metabolism
    • G. Mithieux New knowledge regarding glucose-6-phosphatase gene and protein and their roles in the regulation of glucose metabolism Eur J Endocrinol 136 1997 137 145
    • (1997) Eur J Endocrinol , vol.136 , pp. 137-145
    • Mithieux, G.1
  • 49
    • 0035501248 scopus 로고    scopus 로고
    • Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: A peroxisome proliferators-activated receptor-gamma (PPAR gamma)-independent, antioxidant-related mechanism
    • G.F. Davies, R.L. Khandelwal, L. Wu, B.H. Juurlink, and W.J. Roesler Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferators-activated receptor-gamma (PPAR gamma)-independent, antioxidant-related mechanism Biochem Pharmacol 62 2001 1071 1079
    • (2001) Biochem Pharmacol , vol.62 , pp. 1071-1079
    • Davies, G.F.1    Khandelwal, R.L.2    Wu, L.3    Juurlink, B.H.4    Roesler, W.J.5
  • 50
    • 0025938575 scopus 로고
    • Characterization of CS-045, a new oral antidiabetic agent: I. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice
    • T. Fujiwara, M. Wada, and K. Fukuda Characterization of CS-045, a new oral antidiabetic agent: I. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice Metabolism 40 1991 1213 1218
    • (1991) Metabolism , vol.40 , pp. 1213-1218
    • Fujiwara, T.1    Wada, M.2    Fukuda, K.3
  • 51
    • 0000976950 scopus 로고    scopus 로고
    • BRL 49653 (a thiazolidinedione) improves glycemic control in NIDDM patients
    • J. Patel, E. Miller, J. Hu, and J. Granett BRL 49653 (a thiazolidinedione) improves glycemic control in NIDDM patients Diabetes 46 1997 150A
    • (1997) Diabetes , vol.46
    • Patel, J.1    Miller, E.2    Hu, J.3    Granett, J.4


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