Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 575-582

  Lee, Seung Hong ^a   Min, Kwan Hee ^b   Han, Ji Sook ^b   Lee, Dae Ho ^a   Park, Deok Bae ^a   Jung, Won Kyo ^c   Park, Pyo Jam ^d   Jeon, Byong Tae ^d   Kim, Se Kwon ^e   Jeon, You Jin ^a  

^a Jeju National University   (South Korea)

^b Pusan National University   (South Korea)

^c Chosun University   (South Korea)

^d Konkuk University   (South Korea)

^e Pukyong National University   (South Korea)

Author keywords

Anti diabetic; C57BL KsJ db db mice; Ecklonia cava; Glucose regulating enzyme; Plasma insulin

Indexed keywords

ALGAL EXTRACT; ANTIDIABETIC AGENT; DIECKOL; ECKLONIA CAVA EXTRACT; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; HEMOGLOBIN A1C; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYLASE; POLYPHENOL; ROSIGLITAZONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; BROWN ALGA; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; ECKLONIA CAVA; ENZYME ACTIVITY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; GLYCOGEN LIVER LEVEL; HEMOGLOBIN BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIPID PEROXIDATION; LIVER FUNCTION; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; INSULIN; LIPID METABOLISM; LIPID PEROXIDATION; MICE; MICE, INBRED C57BL; PHAEOPHYTA;

ALGAE; ANIMALIA; ECKLONIA CAVA; MUS; PHAEOPHYCEAE;

EID: 84863259840     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.12.032     Document Type: Article

References (51)

1. Aebi H. Catalase in vitro. Methods Enzymol. 1974, 105:121-126.
2. 2-mediated DNA damage. Eur. Food Res. Technol. 2007, 226:71-79.
3. Ahn M.J., Yoon K.D., Min S.Y., Lee J.S., Kim J.H., Kim T.G., Kim S.H., Kim N.G., Huh H., Kim J. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol. Pharm. Bull. 2004, 27:544-547.
4. Alegre M., Ciudad C.J., Fillat C., Guinovart J.J. Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal. Biochem. 1988, 173:185-189.
5. Aline M., Charles E.L., Marco R., Jeanne M., Odile G.N. Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem. 2005, 9:571-577.
6. Baron A.D. Postprandial hyperglycemia and α-glucosidase inhibitors. Diabetes Res. Clin. Pract. 1998, 40:S51-S55.
7. Basu A., Basu R., Shah P., Vella A., Johnson C.M., Nair K.S., Jensen M.D., Schwenk W.F., Rizza R.A. Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity. Diabetes 2001, 50:1351-1362.
8. Bavarva J.H., Narasimhacharya A.V.R.L. Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats. J. Ethnopharmacol. 2010, 127:98-102.
9. Bentle L.A., Lardy H.A. Interaction of anions and divalent metal ions with phosphopyruvate carboxykinase. J. Biol. Chem. 1976, 251:2916-2921.
10. Boden G. Interaction between free fatty acids and glucose metabolism. Curr. Opin. Clin. Nutr. Metab. Care 2002, 5:545-549.
11. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
12. Cantello B.C.C., Cawthorne M.A., Haigh D., Hindley R.M., Smith S.A., Thurlby P.L. The synthesis of BRL 49653: a novel and potent antihyperglycaemic agent. Bioorg. Med. Chem. Lett. 1997, 4:1181-1184.
13. Chang, M S., Oh M.S., Kim D.R., Jung K.J., Park S., Choi S.B., Ko B.S., Park S.K. Effects of Okchun-San, a herbal formulation, on blood glucose levels and body weight in a model of type 2 diabetes. J. Ethnopharmacol. 2006, 103:491-495.
14. Davidson A.L., Arion W.J. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch. Biochem. Bophys. 1987, 253:156-167.
15. Davies G.F., Khandelwal R.L., Wu L., Juurlink B.H., Roesler W.J. Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferators-activated receptor-gamma (PPAR gamma)-independent, antioxidant-related mechanism. Biochem. Pharmacol. 2001, 62:1071-1079.
16. DeFronzo R.A. Pharmacologic therapy for type 2 diabetes mellitus. Ann. Intern. Med. 1999, 131:281-303.
17. Folch J., Less M., Sloan-Stanley G.H. A simple method for isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957, 226:497-509.
18. Fujiwara T., Wada M., Fukuda K. Characterization of CS-045, a new oral antidiabetic agent: I. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice. Metabolism 1991, 40:1213-1218.
19. Haffner S.M., Miettinen H., Stern M.P. The homeostasis model in the San Antonio heart study. Diabetes Care 1997, 20:1087-1092.
20. Heo S.J., Ko S.C., Cha S.H., Kang D.H., Park H.S., Choi Y.U., Kim D.K., Jung W.K., Jeon Y.J. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol. In Vitro 2009, 23:1123-1130.
21. Hers H.G. The control glycogen metabolism in the liver. Annu. Rev. Biochem. 1976, 45:167-189.
22. Hulcher P.H., Oleson W.H. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J. Lipid Res. 1973, 14:625-631.
23. Irshad M., Chaudhuri P.S. Oxidant-antioxidant system: role and significance in human body. Indian J. Exp. Biol. 2002, 40:1233-1239.
24. Joe M.J., Kim S.N., Choi H.Y., Shin W.S., Park G.M., Kang D.W., Kim Y.K. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol. Pharm. Bull. 2006, 29:1735-1739.
25. Jung U.J., Baek N.I., Chung H.G., Bang M.H., Yoo J.S., Jeong T.S., Lee K.T., Kang Y.J., Lee M.K., Yeo J.Y., Choi M.S. The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice. Food Chem. Toxicol. 2007, 45:2022-2029.
26. Jung U.J., Baek N.I., Chung H.G., Bang M.H., Jeong T.S., Lee K.T., Kang Y.J., Lee M.K., Kim H.J., Yeo J.Y., Choi M.S. Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice. Clin. Nutr. 2008, 27:158-167.
27. Kang C., Jin Y.B., Lee H., Cha M., Sohn E., Moon J., Park C., Chun S., Jung E.S., Hong J.S., Kim S.B., Kim J.S., Kim E. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food Chem. Toxicol. 2010, 48:509-516.
28. Kang K.A., Lee K.H., Chae S.W., Koh Y.S., Yoo B.S., Kim J.H., Ham Y.M., Baik J.S., Lee N.H., Hyun J.W. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radic. Res. 2005, 39:883-892.
29. Katsanons C.S. Lipid-induced insulin resistance in the liver: role of exercise. Sports Med. 2004, 34:955-965.
30. Katz A., Nambi S.S., Mather K., Baron A.D., Follmann D.A., Sullivan G., Quen M.J. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 2000, 85:2402-2410.
31. Kim K.R., Lee J.H., Kim S.J., Rhee S.D., Jung W.H., Yang S.D., Kim S.S., Ahn J.H., Cheon H.G. A novel peroxisome proliferator-activated receptor gamma agonist with weak adipogenic effects. Biochem. Pharmacol. 2006, 72:446-454.
32. Le Q.T., Li Y., Qian Z.J., Kim M.M., Kim S.K. Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release. Process Biochem. 2008, 44:168-176.
33. Lee S.H., Han J.S., Heo S.J., Hwang J.Y., Jeon Y.J. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. Toxicol. In Vitro 2010, 24:375-381.
34. Lee S.H., Park M.H., Heo S.J., Kang S.M., KO S.C., Han J.S., Jeon Y.J. Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro, and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Food Chem. Toxicol. 2010, 48:2633-2637.
35. Marklund S., Marklund G. Involvement of the superoxide anion radical in antioxidant of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
36. McGarry J.D., Kuwajima M., Newgard C.B., Foster D.W. From dietary glucose to liver glycogen: the full circle round. Annu. Rev. Nutr. 1987, 7:51-73.
37. Mithieux G. New knowledge regarding glucose-6-phosphatase gene and protein and their roles in the regulation of glucose metabolism. Eur. J. Endocrinol. 1997, 136:137-145.
38. Mori M.D., Baviera A.M., Ramalho L.T.O., Vendramini R.C., Brunetti I.L., Pepato M.T. Temporal response pattern of biochemical analytes in experimental diabetes. Biotechnol. Appl. Biochem. 2003, 38:183-191.
39. Nordlie R., Bode A.M., Foster J.D. Recent advances in hepatic glucose-6-phosphate regulation and function. Proc. Soc. Exp. Biol. Med. 1993, 3:274-285.
40. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
41. Park S.A., Choi M.S., Cho S.Y., Seo J.S., Jung U.J., Kim M.J., Sung M.K., Park Y.B., Lee M.K. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci. 2006, 79:1207-1213.
42. Park S.A., Choi M.S., Kim M.J., Jung U.J., Kim H.J., Park K.K., Nor H.J., Park H.M., Park Y.B., Lee J.S., Lee M.K. Hypoglycemic and hupolipidemic actionof Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL/KsJ-db/db mice. J. Ethnopharmacol. 2006, 107:412-417.
43. Patel J., Miller E., Hu J., Granett J. BRL 49653 (a thiazolidinedione) improves glycemic control in NIDDM patients. Diabetes 1997, 46(suppl. 1):150A.
44. Postic C., Shiota M., Niswende R.K.D., Jetton T.L., Chen Y., Moates J.M., Shelton K.D., Lindner J., Cherrington A.D., Magnuson M.A. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 1999, 274:305-315.
45. Qi X.Y., Chen W.J., Zhang L.Q., Xie B.J. Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice. Nutr. Res. 2008, 28:278-284.
46. Reitman S., Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 1957, 28:56-63.
47. Seifter S., Dayton S., Novic B., Muntwyler E. The estimation of glycogen with the anthrone reagent. Arch. Biochem. 1950, 25:191-200.
48. Shafrir E. Animal models of non-insulin-dependent diabetes. Diabetes Metab. Rev. 1992, 8:179-208.
49. Waltner-Law M., Wang X., Law B., Hall R., Nawano M., Granner D. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J. Biol. Chem. 2002, 277:34933-34940.
50. Wittenstein B., Klein M., Finckh B., Ullrich K., Kohlschutter A. Plasma antioxidants in pediatric patients with glycogen storage disease, diabetes mellitus, and hypercholesterolemia. Free Radic. Biol. Med. 2002, 33:103-110.
51. Zimmet P., Alberti K., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.