Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice

Food and Chemical Toxicology

Volumn 48, Issue 10, 2010, Pages 2633-2637

  Lee, Seung Hong ^a   Park, Mi Hwa ^b   Heo, Soo Jin ^c   Kang, Sung Myung ^a   Ko, Seok Chun ^a   Han, Ji Sook ^b   Jeon, You Jin ^a  

^a Jeju National University   (South Korea)

^b Pusan National University   (South Korea)

^c Korea Research Institute of Ships and Ocean Engineering   (South Korea)

Author keywords

Amylase; Glucosidase; Diabetic mice; Dieckol; Ecklonia cava; Postprandial hyperglycemia

Indexed keywords

ACARBOSE; ALGAL EXTRACT; ALPHA GLUCOSIDASE; AMYLASE; CARBOHYDRATE; DIECKOL; ECKLONIA CAVA EXTRACT; ENZYME INHIBITOR; GLUCOSE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CARBOHYDRATE ABSORPTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG ISOLATION; ECKLONIA CAVA; ENDOTHELIUM CELL; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; POSTPRANDIAL STATE; STREPTOZOCIN DIABETES; TOXICITY TESTING; UMBILICAL VEIN;

ALPHA-AMYLASES; ANIMALS; AREA UNDER CURVE; BENZOFURANS; BLOOD GLUCOSE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GLUCAN 1,4-ALPHA-GLUCOSIDASE; HUMANS; HYPERGLYCEMIA; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PHAEOPHYTA; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

ECKLONIA CAVA; MUS; PHAEOPHYCEAE;

EID: 77956341108     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.06.032     Document Type: Article

References (33)

1. 2-mediated DNA damage. Eur. Food Res. Technol. 2007, 226:71-79.
2. Baron A.D. Postprandial hyperglycemia and α-glucosidase inhibitors. Diabetes Res. Clin. Pract. 1998, 40:S51-S55.
3. Bhandari M.R., Jong-Anurakkun N., Hong G., Kawabata J. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata Haw.). Food Chem. 2008, 106:247-252.
4. Charpentier G., Riveline J.P., Varroud-Vial M. Management of drugs affecting blood glucose in diabetic patients with renal failure. Diabetes Metab. 2000, 26:73-85.
5. Cherng J.Y., Shih M.F. Improving glycogenesis in Streptozotocin (STZ) diabetic mice after administration of green algae Chlorella. Life Sci. 2006, 78:1181-1186.
6. Dennis J.W., Laferte S., Waghorne C., Breitman M.L., Kerbel R.S. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 1987, 236:582-585.
7. Diaz-Gutierrez F.L., Ladero J.M., Diaz-Rubio M. Acarbose-induced acute hepatitis. Am. J. Gastroenterol. 1998, 93:481.
8. Fautz R., Husen B., Hechenberger C. Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat Res. 1991, 253:173-179.
9. Gray D.M. Carbohydrate digestion and absorption role of small intestine. N. Engl. J. Med. 1995, 29:1225-1230.
10. Gruters R.A., Neefjes J.J., Tersmette M., De Goede R.E.Y., Tulp A., Huisman H.G., Miedema F., Ploegh H.L. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 1987, 330:74-77.
11. Halliwell B., Gutteridge J.M.C. Antioxidant defenses. Free Radicals in Biology and Medicine 1999, 105-199. Oxford, UK. 3rd ed. B. Halliwell, J.M.C. Gutteridge (Eds.).
12. Hanefeld M. The role of acarbose in the treatment of non-insulin-dependent diabetes mellitus. J. Diabetes Complicat. 1998, 12:228-237.
13. Hara Y., Honda M. The inhibition of α-amylase by tea polyphenols. Agric. Biol. Chem. 1990, 54:1939-1945.
14. Heo S.J., Park E.J., Lee K.W., Jeon Y.J. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour. Technol. 2005, 96:1613-1623.
15. Heo S.J., Hwang J.Y., Choi J.I., Han J.S., Kim H.J., Jeon Y.J. Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur. J. Pharmacol. 2009, 615:252-256.
16. Inoue I., Takahashi K., Noji S., Awata T., Negishi K., Katayama S. Acarbose controls postprandial hyper-proinsulinemia in non-insulin-dependent diabetes mellitus. Diabetes Res. Clin. Pract. 1997, 36:143-151.
17. Kang S.I., Jin Y.J., Ko H.C., Choi S.Y., Hwang J.H., Whang I., Kim M.H., Shin H.S., Jeong H.B., Kim S.J. Petalonia improves glucose homeostasis in streptozotocin-induced diabetic mice. Biochem. Biophys. Res. Commun. 2008, 373:264-269.
18. Kang K.A., Lee K.H., Chae S.W., Zhang R., Jung M.S., Lee Y., Kim S.Y., Kim H.S., Joo H.G., Park J.W., Ham Y.M., Lee N.H., Hyun J.W. Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS Lett. 2005, 579:6295-6304.
19. Kang K.A., Lee K.H., Chae S.W., Koh Y.S., Yoo B.S., Kim J.H., Ham Y.M., Baik J.S., Lee N.H., Hyun J.W. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radic. Res. 2005, 39:883-892.
20. Kim J.S. Effect of Rhemanniae Radix on the hyperglycemic mice induced with streptozotocin. J. Korea Soc. Food Sci. Nut. 2004, 33:1133-1138.
21. Kim K.Y., Nam K.A., Kurihara H., Kim S.M. Potent α-glucosidase inhibitors purified from the red alga Grateloupia elliptica. Phytochemistry 2008, 69:2820-2825.
22. Krentz A.J., Bailey C.J. Oral antidiabetic agents. Current role in type 2 diabetes mellitus. Drugs 2005, 65:385-411.
23. Lebovitz H.E. α-glucosidase inhibitors. Endocrinol. Metab. Clin. 1997, 26:539-551.
24. Lee S.H., Han J.S., Heo S.J., Hwang J.Y., Jeon Y.J. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. Toxicol In Vitro. 2010, 24:375-381.
25. Li Y., Wen S., Kota B.P., Peng G., Li G.Q., Yamahara J. Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J. Ethnopharmacol. 2005, 99:239-244.
26. Matsui T., Tanaka T., Tamura S., Toshima A., Miyata Y., Tanaka K., Matsumoto K. α-glucosidase inhibitory profile of catechins and theaflavins. J. Agric. Food Chem. 2007, 55:99-105.
27. Saito N., Sakai H., Sekihara H., Yajima Y. Effect of an α-glucosidase inhibitor (volibose), in combination with sulphonilureas, on glycaemic control in type 2 diabetes patients. J. Int. Med. Res. 1998, 26:219-232.
28. Sels J.P., Huijberts M.S., Wolffenbuttel B.H. Miglitol, a new alpha-glucosidase inhibitor. Expert. Opin. Pharmacother. 1999, 1:149-156.
29. Stand E., Baumgartl H.J., Fuchtenbusch M., Stemplinger J. Effect of acarbose on additional insulin therapy in type 2 diabetic patients with late failure of sulphonylurea therapy. Diabetes. Obes. Metab. 1999, 1:215-220.
30. Stern J.L., Hagerman A.E., Steinberg P.D., Mason P.K. Phlorotannins-protein interactions. J. Chem. Ecol. 1996, 22:1877-1899.
31. Watanabe J., Kawabata J., Kurihara H., Niki R. Isolation and identification of alpha-glucosidase inhibitors from Tochucha (Eucommia ulmoides). Biosci. Biotechnol. Biochem. 1997, 61:177-178.
32. Winchester B., Fleet G.W. Amino-sugar glycosidase inhibitors: versatile tools for glycobiologists. Glycobiology 1992, 2:199-210.
33. Zimmet P., Alberti K., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.