G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene

BioEssays

Volumn 35, Issue 5, 2013, Pages 430-435

  Regué, Laura ^a,b   Mou, Fan ^a,b   Avruch, Joseph ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

F actin; G protein coupled receptors; Galpha12 13; Hippo; TAZ; YAP

Indexed keywords

F ACTIN; G PROTEIN COUPLED RECEPTOR; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL POLARITY; DEPHOSPHORYLATION; DROSOPHILA; EPITHELIUM CELL; MAMMAL; NONHUMAN; ONCOGENE; REGULATORY MECHANISM;

ACTIN CYTOSKELETON; ACTINS; ANIMALS; CELL POLARITY; CELL TRANSFORMATION, NEOPLASTIC; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GUANOSINE TRIPHOSPHATE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

MAMMALIA;

EID: 84876326725     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201200163     Document Type: Article

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