-
1
-
-
0038481970
-
The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
-
DOI 10.1038/nrc1098
-
Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil'hypothesis revisited. Nat Rev Cancer 2003;3:453-8. (Pubitemid 37328849)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.6
, pp. 453-458
-
-
Fidler, I.J.1
-
2
-
-
55749112156
-
Melanoma and the tumor microenvironment
-
Villanueva J, Herlyn M. Melanoma and the tumor microenvironment. Curr Oncol Rep 2008;10:439-46.
-
(2008)
Curr Oncol Rep
, vol.10
, pp. 439-446
-
-
Villanueva, J.1
Herlyn, M.2
-
3
-
-
36049033674
-
The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression
-
DOI 10.1016/S0049-3848(07)70135-4, PII S0049384807701354
-
Milsom C, Yu J, May L, Meehan B, Magnus N, Al-Nedawi K, et al. The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression. Thromb Res 2007;120[Suppl 2]:S82-91. (Pubitemid 350101776)
-
(2007)
Thrombosis Research
, vol.120
, Issue.SUPPL. 2
-
-
Milsom, C.1
Yu, J.2
May, L.3
Meehan, B.4
Magnus, N.5
Al-Nedawi, K.6
Luyendyk, J.7
Weitz, J.8
Klement, P.9
Broze, G.10
Mackman, N.11
Rak, J.12
-
4
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000;407:258-64.
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
5
-
-
79960883524
-
The emerging role of the thrombin receptor (PAR-1) in melanoma metastasis-a possible therapeutic target
-
Villares GJ, Zigler M, Bar-Eli M. The emerging role of the thrombin receptor (PAR-1) in melanoma metastasis-a possible therapeutic target. Oncotarget 2011;2:8-17.
-
(2011)
Oncotarget
, vol.2
, pp. 8-17
-
-
Villares, G.J.1
Zigler, M.2
Bar-Eli, M.3
-
6
-
-
49649107043
-
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis
-
Hu L, Roth JM, Brooks P, Luty J, Karpatkin S. Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis. Cancer Res 2008;68:4666-73.
-
(2008)
Cancer Res
, vol.68
, pp. 4666-4673
-
-
Hu, L.1
Roth, J.M.2
Brooks, P.3
Luty, J.4
Karpatkin, S.5
-
7
-
-
0032533268
-
Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis
-
Nierodzik ML, Chen K, Takeshita K, Li JJ, Huang YQ, Feng XS, et al. Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. Blood 1998;92:3694-700. (Pubitemid 28525196)
-
(1998)
Blood
, vol.92
, Issue.10
, pp. 3694-3700
-
-
Nierodzik, M.L.1
Chen, K.2
Takeshita, K.3
Li, J.-J.4
Huang, Y.-Q.5
Feng, X.-S.6
D'Andrea, M.R.7
Andrade-Gordon, P.8
Karpatkin, S.9
-
8
-
-
33750616197
-
Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype
-
DOI 10.1016/j.ccr.2006.10.002, PII S1535610806002868
-
Nierodzik ML, Karpatkin S. Thrombin induces tumor growth, metastasis, and angiogenesis: evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell 2006;10:355-62. (Pubitemid 44693468)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 355-362
-
-
Nierodzik, M.L.1
Karpatkin, S.2
-
9
-
-
0141819106
-
Tissue factor, thrombin, and cancer
-
Rickles FR, Patierno S, Fernandez PM. Tissue factor, thrombin, and cancer. Chest 2003;124[Suppl]:58S-68S. (Pubitemid 37128437)
-
(2003)
Chest
, vol.124
, Issue.3 SUPPL.
-
-
Rickles, F.R.1
Patierno, S.2
Fernandez, P.M.3
-
10
-
-
21544440159
-
Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
-
DOI 10.1016/j.humpath.2005.04.008, PII S0046817705001954
-
Massi D, Naldini A, Ardinghi C, Carraro F, Franchi A, Paglierani M, et al. Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma. Hum Pathol 2005;36:676-85. (Pubitemid 40922575)
-
(2005)
Human Pathology
, vol.36
, Issue.6
, pp. 676-685
-
-
Massi, D.1
Naldini, A.2
Ardinghi, C.3
Carraro, F.4
Franchi, A.5
Paglierani, M.6
Tarantini, F.7
Ketabchi, S.8
Cirino, G.9
Hollenberg, M.D.10
Geppetti, P.11
Santucci, M.12
-
11
-
-
55349098455
-
Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA
-
Villares GJ, Zigler M, Wang H, Melnikova VO, Wu H, Friedman R, et al. Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA. Cancer Res 2008;68:9078-86.
-
(2008)
Cancer Res
, vol.68
, pp. 9078-9086
-
-
Villares, G.J.1
Zigler, M.2
Wang, H.3
Melnikova, V.O.4
Wu, H.5
Friedman, R.6
-
12
-
-
70350398248
-
Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis
-
Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, et al. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem 2009;284:28845-55.
-
(2009)
J Biol Chem
, vol.284
, pp. 28845-28855
-
-
Melnikova, V.O.1
Balasubramanian, K.2
Villares, G.J.3
Dobroff, A.S.4
Zigler, M.5
Wang, H.6
-
13
-
-
69249096952
-
Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43
-
Villares GJ, Dobroff AS, Wang H, Zigler M, Melnikova VO, Huang L, et al. Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43. Cancer Res 2009;69:6730-7.
-
(2009)
Cancer Res
, vol.69
, pp. 6730-6737
-
-
Villares, G.J.1
Dobroff, A.S.2
Wang, H.3
Zigler, M.4
Melnikova, V.O.5
Huang, L.6
-
14
-
-
79551678748
-
Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype
-
Villares GJ, Zigler M, Dobroff AS, Wang H, Song R, Melnikova VO, et al. Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype. Proc Natl Acad Sci U S A 2011;108:626-31.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 626-631
-
-
Villares, G.J.1
Zigler, M.2
Dobroff, A.S.3
Wang, H.4
Song, R.5
Melnikova, V.O.6
-
15
-
-
3543121913
-
Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
-
Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM. Proteaseactivated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res 2004;2:395-402. (Pubitemid 39031073)
-
(2004)
Molecular Cancer Research
, vol.2
, Issue.7
, pp. 395-402
-
-
Shi, X.1
Gangadharan, B.2
Brass, L.F.3
Ruf, W.4
Mueller, B.M.5
-
16
-
-
34147206365
-
Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression
-
DOI 10.1158/1541-7786.MCR-06-0261
-
Salah Z, Maoz M, Pokroy E, Lotem M, Bar-Shavit R, Uziely B. Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression. Mol Cancer Res 2007;5:229-40. (Pubitemid 46577967)
-
(2007)
Molecular Cancer Research
, vol.5
, Issue.3
, pp. 229-240
-
-
Salah, Z.1
Maoz, M.2
Pokroy, E.3
Lotem, M.4
Bar-Shavit, R.5
Uziely, B.6
-
17
-
-
71349087406
-
A matrix metalloproteinase- 1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis
-
Blackburn JS, Liu I, Coon CI, Brinckerhoff CE. A matrix metalloproteinase- 1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis. Oncogene 2009;28:4237-48.
-
(2009)
Oncogene
, vol.28
, pp. 4237-4248
-
-
Blackburn, J.S.1
Liu, I.2
Coon, C.I.3
Brinckerhoff, C.E.4
-
18
-
-
34247388037
-
Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer
-
DOI 10.1242/jcs.03409
-
Arora P, Ricks TK, Trejo J. Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci 2007;120: 921-8. (Pubitemid 46638507)
-
(2007)
Journal of Cell Science
, vol.120
, Issue.6
, pp. 921-928
-
-
Arora, P.1
Ricks, T.K.2
Trejo, J.3
-
19
-
-
1342325343
-
Persistent Signaling by Dysregulated Thrombin Receptor Trafficking Promotes Breast Carcinoma Cell Invasion
-
DOI 10.1128/MCB.24.5.1990-1999.2004
-
Booden MA, Eckert LB, Der CJ, Trejo J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol 2004;24:1990-9. (Pubitemid 38248939)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.5
, pp. 1990-1999
-
-
Booden, M.A.1
Eckert, L.B.2
Der, C.J.3
Trejo, J.4
-
21
-
-
68049143326
-
Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis
-
Yang E, Boire A, Agarwal A, Nguyen N, O'Callaghan K, Tu P, et al. Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis. Cancer Res 2009;69:6223-31.
-
(2009)
Cancer Res
, vol.69
, pp. 6223-6231
-
-
Yang, E.1
Boire, A.2
Agarwal, A.3
Nguyen, N.4
O'Callaghan, K.5
Tu, P.6
-
22
-
-
0037406817
-
Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells
-
Darmoul D, Gratio V, Devaud H, Lehy T, Laburthe M. Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells. Am J Pathol 2003;162:1503-13. (Pubitemid 36512832)
-
(2003)
American Journal of Pathology
, vol.162
, Issue.5
, pp. 1503-1513
-
-
Darmoul, D.1
Gratio, V.2
Devaud, H.3
Lehy, T.4
Laburthe, M.5
-
23
-
-
0036845746
-
A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines
-
DOI 10.1016/S0090-4295(02)01969-6, PII S0090429502019696
-
Chay CH, Cooper CR, Gendernalik JD, Dhanasekaran SM, Chinnaiyan AM,RubinMA,et al.Afunctional thrombin receptor (PAR1)isexpressed on bone-derived prostate cancer cell lines. Urology 2002;60:760-5. (Pubitemid 35300332)
-
(2002)
Urology
, vol.60
, Issue.5
, pp. 760-765
-
-
Chay, C.H.1
Cooper, C.R.2
Gendernalik, J.D.3
Dhanasekaran, S.M.4
Chinnaiyan, A.M.5
Rubin, M.A.6
Schmaier, A.H.7
Pienta, K.J.8
-
24
-
-
2942530298
-
Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors
-
DOI 10.1002/pros.20047
-
Wilson SR, Gallagher S, Warpeha K, Hawthorne SJ. Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors. Prostate 2004;60:168-74. (Pubitemid 38758582)
-
(2004)
Prostate
, vol.60
, Issue.2
, pp. 168-174
-
-
Wilson, S.R.1
Gallagher, S.2
Warpeha, K.3
Hawthorne, S.J.4
-
25
-
-
0034969753
-
Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues
-
D'Andrea MR, Derian CK, Santulli RJ, Andrade-Gordon P. Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am J Pathol 2001;158:2031-41. (Pubitemid 32545189)
-
(2001)
American Journal of Pathology
, vol.158
, Issue.6
, pp. 2031-2041
-
-
D'Andrea, M.R.1
Derian, C.K.2
Santulli, R.J.3
Andrade-Gordon, P.4
-
26
-
-
33646003861
-
Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells
-
Tarzami ST, Wang G, Li W, Green L, Singh JP. Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells. J Thromb Haemost 2006;4:656-63.
-
(2006)
J Thromb Haemost
, vol.4
, pp. 656-663
-
-
Tarzami, S.T.1
Wang, G.2
Li, W.3
Green, L.4
Singh, J.P.5
-
27
-
-
79953092222
-
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
-
Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 2011;117:3199-208.
-
(2011)
Blood
, vol.117
, pp. 3199-3208
-
-
Sen, P.1
Gopalakrishnan, R.2
Kothari, H.3
Keshava, S.4
Clark, C.A.5
Esmon, C.T.6
-
28
-
-
0037352279
-
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
-
DOI 10.1038/nm826
-
Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003;9: 338-42. (Pubitemid 36362790)
-
(2003)
Nature Medicine
, vol.9
, Issue.3
, pp. 338-342
-
-
Cheng, T.1
Liu, D.2
Griffin, J.H.3
Fernandez, J.A.4
Castellino, F.5
Rosen, E.D.6
Fukudome, K.7
Zlokovic, B.V.8
-
29
-
-
3142592165
-
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
-
DOI 10.1182/blood-2004-02-0434
-
Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 2004;104:397-401. (Pubitemid 38900020)
-
(2004)
Blood
, vol.104
, Issue.2
, pp. 397-401
-
-
Camerer, E.1
Qazi, A.A.2
Duong, D.N.3
Cornelissen, I.4
Advincula, R.5
Coughlin, S.R.6
-
30
-
-
0023946733
-
Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo
-
Karpatkin S, Pearlstein E, Ambrogio C, Coller BS. Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo. J Clin Invest 1988;81:1012-9.
-
(1988)
J Clin Invest
, vol.81
, pp. 1012-1019
-
-
Karpatkin, S.1
Pearlstein, E.2
Ambrogio, C.3
Coller, B.S.4
-
31
-
-
64249129547
-
Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site
-
Trivedi V, Boire A, Tchernychev B, Kaneider NC, Leger AJ, O'Callaghan K, et al. Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site. Cell 2009;137: 332-43.
-
(2009)
Cell
, vol.137
, pp. 332-343
-
-
Trivedi, V.1
Boire, A.2
Tchernychev, B.3
Kaneider, N.C.4
Leger, A.J.5
O'Callaghan, K.6
-
32
-
-
0141905920
-
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1
-
DOI 10.1042/BJ20030346
-
Chalmers CJ, Balmanno K, Hadfield K, Ley R, Cook SJ. Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. Biochem J 2003;375:99-109. (Pubitemid 37255385)
-
(2003)
Biochemical Journal
, vol.375
, Issue.1
, pp. 99-109
-
-
Chalmers, C.J.1
Balmanno, K.2
Hadfield, K.3
Ley, R.4
Cook, S.J.5
-
33
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-19.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
-
34
-
-
77949876317
-
Thrombin receptor antagonism-the potential of antiplatelet medication SCH 530348
-
Macaulay TE, Allen C, Ziada KM. Thrombin receptor antagonism-the potential of antiplatelet medication SCH 530348. Expert Opin Pharmacother 2010;11:1015-22.
-
(2010)
Expert Opin Pharmacother
, vol.11
, pp. 1015-1022
-
-
Macaulay, T.E.1
Allen, C.2
Ziada, K.M.3
-
35
-
-
74849103625
-
Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype
-
Silini A, Ghilardi C, Ardinghi C, Bernasconi S, Oliva P, Carraro F, et al. Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype. Clin Exp Metastasis 2010;27:43-53.
-
(2010)
Clin Exp Metastasis
, vol.27
, pp. 43-53
-
-
Silini, A.1
Ghilardi, C.2
Ardinghi, C.3
Bernasconi, S.4
Oliva, P.5
Carraro, F.6
-
36
-
-
79751476524
-
High prevalence and risk factors of thromboembolism in stage IV melanoma
-
Sparsa A, Durox H, Doffoel-Hantz V, Munyangango EM, Bédane C, Cendras J, et al. High prevalence and risk factors of thromboembolism in stage IV melanoma. J Eur Acad Dermatol Venereol 2011;25:340-4.
-
(2011)
J Eur Acad Dermatol Venereol
, vol.25
, pp. 340-344
-
-
Sparsa, A.1
Durox, H.2
Doffoel-Hantz, V.3
Munyangango, E.M.4
Bédane, C.5
Cendras, J.6
-
37
-
-
72249120877
-
Thrombin's central role in angiogenesis and pathophysiological processes
-
Tsopanoglou NE, Maragoudakis ME. Thrombin's central role in angiogenesis and pathophysiological processes. Eur Cytokine Netw 2009;20:171-9.
-
(2009)
Eur Cytokine Netw
, vol.20
, pp. 171-179
-
-
Tsopanoglou, N.E.1
Maragoudakis, M.E.2
|