Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 4, 2009, Pages

  Inoue, Kazuyoshi ^a   Sodhi, Komal ^a   Puri, Nitin ^a   Gotlinger, Katherine H ^a   Cao, Jiang ^a   Rezzani, Rita ^b   Falck, John R ^c   Abraham, Nader G ^a,d   Laniado Schwartzman, Michal ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Cyp4a derived 20 HETE; Endothelial dysfunction; Endothelial specific promoter; Lentiviral vectors; Oxidative stress

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ACETYLCHOLINE; CYTOCHROME P450 4A; CYTOCHROME P450 4A2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FORMAMIDE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N HYDROXY NALPHA (4 BUTYL 2 METHYLPHENYL)FORMAMIDINE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENDOTHELIAL DYSFUNCTION; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY FUNCTION; KIDNEY INJURY; LENTIVIRINAE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEINURIA; RAT; VASCULAR ENDOTHELIUM; VASODILATATION; WESTERN BLOTTING;

EID: 70349648137     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00364.2009     Document Type: Article

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