Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs

Analytical Biochemistry

Volumn 292, Issue 1, 2001, Pages 115-124

  Nithipatikom, Kasem ^a   DiCamelli, Ralph F ^a   Kohler, Stephanie ^a   Gumina, Richard J ^a   Falck, John R ^b   Campbell, William B ^a   Gross, Garrett J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

20 hydroxyeicosatetraenoic acid; Cytochrome P450; Dihydroxyeicosatrienoic acids; Endothelium dependent hyperpolarizing factor; Epoxyeicosatrienoic acids; Ischemia reperfusion

Indexed keywords

BIOACTIVITY; BIOMOLECULES; ESTERS; ETHERS; GAS CHROMATOGRAPHY; HEART; IONIZATION OF GASES; MASS SPECTROMETRY; METABOLITES; NEGATIVE IONS; UNSATURATED FATTY ACIDS;

BIOLOGICALLY ACTIVE COMPOUNDS; CYTOCHROME P450; ENDOTHELIUM-DEPENDENT HYPERPOLARIZING FACTOR; EPOXYEICOSATRIENOIC ACIDS; GAS CHROMATOGRAPHIC COLUMN; ISCHEMIA REPERFUSION; NEGATIVE ION CHEMICAL IONIZATION; SPECTROMETRIC TECHNIQUES;

ASCORBIC ACID;

11,12 DIHYDROXYEICOSATRIENOIC ACID; 14,15 DIHYDROXYEICOSATRIENOIC ACID; 14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; 5,6 DIHYDROXYEICOSATRIENOIC ACID; 8,9 DIHYDROXYEICOSATRIENOIC ACID; ARACHIDONIC ACID; HYDROXYICOSATETRAENOIC ACID; ICOSANOID; ICOSATRIENOIC ACID; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL TONE; CAPILLARY GAS CHROMATOGRAPHY; CORRELATION FUNCTION; DOG; ENZYME ASSAY; GAS CHROMATOGRAPHY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; NONHUMAN; PRIORITY JOURNAL;

CANIS FAMILIARIS;

EID: 0035337058     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2001.5044     Document Type: Article

References (30)

1. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the vascular tone
2. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
3. Cytochrome P450 and the arachidonate cascade
4. Cytochrome P-450 metabolism of arachidonic acid
5. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle
6. Arachidonic acid and acetylcholine-induced relaxation of rabbit aorta
7. Identification of epoxyeicosatrienoic acids as endothelial-derived hyperpolarizing factors
8. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation
9. Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids
10. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle
11. 20-Hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries
12. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries
13. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels
14. + channel in renal arterioles
15. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue
16. Synthesis and relevance of cardiac eicosanoids with particular emphasis on ischemia and reperfusion
17. Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions
18. Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries
19. Role of EDHF in regulation of coronary blood flow of ischemic myocardium
20. Optimization of epoxyeicosatrienoic acid synthesis to test their effects on cerebral blood flow in vivo
21. Identification of arachidonate epoxides/diols by capillary chromatography-mass spectrometry
22. Endogenous biosynthesis of arachidonic acid epoxides in human: Increased formation in pregnancy-induced hypertension
23. 20-Hydroxyeicosatrienoic acid is excreted as a glucuronide conjugate in human urine
24. Selective epoxidation of eicosa-cis-5,8,11,14-tetraenoic (arachidonic) acid and eicosa-cis-8,11,13-trienoic acid
25. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil functions in dogs
26. Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog
27. Reduction in myocardial infarct size by the new potassium channel opener, bimakalim
28. Determination of epoxyeicosatrienoic acids using microbore liquid chromatography with fluorescence detection
29. Rapid Extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica
30. A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol