Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury

Current Opinion in Nephrology and Hypertension

Volumn 21, Issue 1, 2012, Pages 33-38

  Regner, Kevin R ^a   Roman, Richard J ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

acute kidney injury; hemodynamics; kidney; renal medulla

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ANGIOPOIETIN 1; ATRIAL NATRIURETIC FACTOR; HEME OXYGENASE 1;

ACUTE KIDNEY FAILURE; HUMAN; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY MEDULLA; KIDNEY VASCULAR RESISTANCE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW;

ACUTE KIDNEY INJURY; ANGIOPOIETIN-1; ANIMALS; ATRIAL NATRIURETIC FACTOR; CARBON MONOXIDE; HEME OXYGENASE-1; HUMANS; HYDROGEN SULFIDE; HYDROXYEICOSATETRAENOIC ACIDS; KIDNEY MEDULLA; RENAL CIRCULATION; REPERFUSION INJURY;

EID: 83055186460     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32834d085a     Document Type: Review

References (63)

1. Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16:3365-3370. (Pubitemid 46179340)
2. Lameire N, Van Biesen W, Vanholder R. The changing epidemiology of acute renal failure. Nat Clin Pract Nephrol 2006; 2:364-377. (Pubitemid 44034187)
3. Lameire N, Vanholder R. Pathophysiologic features and prevention of human and experimental acute tubular necrosis. J Am Soc Nephrol 2001; 12:S20-S32. (Pubitemid 32119050)
4. Lamiere N. The changing epidemiology of acute renal failure. Nat Clin Pract Nephrol 2006; 2:364-377.
5. Bonventre JV, Weinberg JM. Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 2003; 14:2199-2210. (Pubitemid 36909930)
6. Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 2006; 17:1503-1520. (Pubitemid 43841396)
7. Padanilam BJ. Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 2003; 284:F608-627. (Pubitemid 36336968)
8. Herrler T, Tischer A, Meyer A, et al. The intrinsic renal compartment syndrome: new perspectives in kidney transplantation. Transplantation 2010; 89:40-46.
9. Sutton TA, Fisher CJ, Molitoris BA. Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int 2002; 62:1539-1549. (Pubitemid 35286261)
10. Vetterlein F, Petho A, Schmidt G. Distribution of capillary blood flow in rat kidney during postischemic renal failure. Am J Physiol 1986; 251:H510-H519.
11. Yamamoto T, Tada T, Brodsky SV, et al. Intravital videomicroscopy of peritubular capillaries in renal ischemia. Am J Physiol Renal Physiol 2002; 282:F1150-F1155. (Pubitemid 34654481)
12. Cristol JP, Thiemermann C, Mitchell JA, et al. Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites. Br J Pharmacol 1993; 109:188-194. (Pubitemid 23113821)
13. Cristol JP, Thiemermann C, Guerin MC, et al. L-Arginine infusion after ischaemia-reperfusion of rat kidney enhances lipid peroxidation. J Lipid Mediat Cell Signal 1996; 13:9-17.
14. Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 2000; 95:3781-3787. (Pubitemid 30412850)
15. Nijveldt RJ, Prins HA, van Kemenade FJ, et al. Low arginine plasma levels do not aggravate renal blood flow after experimental renal ischaemia/ reperfusion. Eur J Vasc Endovasc Surg 2001; 22:232-239. (Pubitemid 32780788)
16. Ramaswamy D, Corrigan G, Polhemus C, et al. Maintenance and recovery stages of postischemic acute renal failure in humans. Am J Physiol Renal Physiol 2002; 282:F271-F280. (Pubitemid 34654558)
17. Conesa EL, Valero F, Nadal JC, et al. N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure. Am J Physiol Regul Integr Comp Physiol 2001; 281:R730-R737.
18. Olof P, Hellberg A, Kallskog O, Wolgast M. Red cell trapping and postischemic renal blood flow. Differences between the cortex, outer and inner medulla. Kidney Int 1991; 40:625-631.
19. Regner KR, Zuk A, Van Why SK, et al. Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. Kidney Int 2009; 75:511-517.
20. Brezis M, Rosen S. Hypoxia of the renal medulla: its implications for disease. N Engl J Med 1995; 332:647-655.
21. Tumlin JA. Impaired blood flow in acute kidney injury: pathophysiology and potential efficacy of intrarenal vasodilator therapy. Curr Opin Crit Care 2009; 15:514-519.
22. Hoff U, Lukitsch I, Chaykovska L, et al. Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. Kidney Int 2011; 79: 57-65.
23. Salom MG, Ceron SN, Rodriguez F, et al. Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite. Am J Physiol Heart Circ Physiol 2007; 293:H3542-H3549. (Pubitemid 350230898)
24. Beltowski J. Hypoxia in the renal medulla: implications for hydrogen sulfide signaling. J Pharmacol Exp Ther 2010; 334:358-363.
25. Xia M, Chen L, Muh RW, et al. Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys. J Pharmacol Exp Ther 2009; 329:1056-1062.
26. Vera T, Henegar JR, Drummond HA, et al. Protective effect of carbon monoxide-releasing compounds in ischemia-induced acute renal failure. J Am Soc Nephrol 2005; 16:950-958. (Pubitemid 41710305)
27. Hosgood SA, Bagul A, Kaushik M, et al. Application of nitric oxide and carbon monoxide in a model of renal preservation. Br J Surg 2008; 95:1060-1067.
28. Jeansson M, Gawlik A, Anderson G, et al. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 2011; 121: 2278-2289.
29. Chien KR, Han A, Sen A, et al. Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids. Circ Res 1984; 54:313-322. (Pubitemid 14172442)
30. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002; 82:131-185. (Pubitemid 34654217)
31. Nithipatikom K, Gross ER, Endsley MP, et al. Inhibition of cytochrome P450{omega}-hydroxylase: a novel endogenous cardioprotective pathway. Circ Res 2004; 95:e65-e71.
32. Renic M, Klaus JA, Omura T, et al. Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 2009; 29:629-639.
33. Oyekan AO. Differential effects of 20-hydroxyeicosatetraenoic acid on intrarenal blood flow in the rat. J Pharmacol Exp Ther 2005; 313:1289-1295. (Pubitemid 40727034)
34. Roman RJ, Akbulut T, Park F, Regner KR. 20-HETE in acute kidney injury. Kidney Int 2011; 79: 10-13.
35. Young LS, Regan MC, Sweeney P, et al. Changes in regional renal blood flow after unilateral nephrectomy using the techniques of autoradiography and microautoradiography. J Urol 1998; 160:926-931. (Pubitemid 29479556)
36. Nath KA. Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues. Kidney Int 2006; 70:432-443. (Pubitemid 44141569)
37. Zou AP, Billington H, Su N, Cowley AW Jr. Expression and actions of heme oxygenase in the renal medulla of rats. Hypertension 2000; 35:342-347. (Pubitemid 30054197)
38. Waller HL, Harper SJ, Hosgood SA, et al. Differential expression of cytoprotective and apoptotic genes in an ischaemia-reperfusion isolated organ perfusion model of the transplanted kidney. Transpl Int 2007; 20:625-631. (Pubitemid 46872753)
39. Tracz MJ, Juncos JP, Croatt AJ, et al. Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia. Kidney Int 2007; 72:1073-1080. (Pubitemid 47609038)
40. Matsumoto M, Makino Y, Tanaka T, et al. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 2003; 14:1825-1832. (Pubitemid 36750477)
41. Mustafa AK, Gadalla MM, Snyder SH. Signaling by gasotransmitters. Sci Signal 2009; 2:re2.
42. Cowley AW, Mori T, Mattson D, Zou A-P. Role of renal NO production in the regulation of medullary blood flow. Am J Physiol Regul Integr Comp Physiol 2003; 284:R1355-R1369. (Pubitemid 36621413)
43. O'Connor PM, Cowley AW Jr. Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide. Curr Hypertens Rep 2010; 12:86-92.
44. Pallone TL, Mattson DL. Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys. Curr Opin Nephrol Hypertens 2002; 11:93-98. (Pubitemid 34053344)
45. Forstermann U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch 2010; 459:923-939.
46. Legrand M, Mik EG, Johannes T, et al. Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med 2008; 14:502-516.
47. Goligorsky MS, Brodsky SV, Noiri E. NO bioavailability, endothelial dysfunction, and acute renal failure: new insights into pathophysiology. Semin Nephrol 2004; 24:316-323. (Pubitemid 38900631)
48. Goligorsky MS, Brodsky SV, Noiri E. Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int 2002; 61:855-861. (Pubitemid 34175452)
49. Heemskerk S, Masereeuw R, Russel FG, Pickkers P. Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol 2009; 5:629-640.
50. Tripatara P, Patel NSA, Brancaleone V, et al. Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in-vivo study. Eur J Pharmacol 2009; 606:205-209.
51. Hosgood SA, Nicholson ML. Hydrogen sulphide ameliorates ischaemiareperfusion injury in an experimental model of nonheart-beating donor kidney transplantation. Br J Surg 2010; 97:202-209.
52. Ferenbach DA, Kluth DC, Hughes J. Hemeoxygenase-1 and renal ischaemiareperfusion injury. Nephron Exp Nephrol 2010; 115:e33-e37.
53. Neto JS, Nakao A, Kimizuka K, et al. Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol 2004; 287:F979-F989. (Pubitemid 39391095)
54. Kiberd BA, Larson TS, Robertson CR, Jamison RL. Effect of atrial natriuretic peptide on vasa recta blood flow in the rat. Am J Physiol Renal Physiol 1987; 252:F1112-F1117.
55. Chujo K, Ueno M, Asaga T, et al. Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. J Biosci Bioeng 2010; 109:526-530.
56. Nigwekar SU, Navaneethan SD, Parikh CR, Hix JK. Atrial natriuretic peptide for preventing and treating acute kidney injury. Cochrane Database Syst Rev 2009:CD006028.
57. Cho CH, Kammerer RA, Lee HJ, et al. COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proc Natl Acad Sci USA 2004; 101:5547-5552. (Pubitemid 38481194)
58. Jung YJ, Kim DH, Lee AS, et al. Peritubular capillary preservation with COMPangiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury. Am J Physiol Renal Physiol 2009; 297:F952-F960.
59. Coca SG, Yusuf B, Shlipak MG, et al. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and metaanalysis. Am J Kidney Dis 2009; 53:961-973.
60. Triverio P-A, Martin P-Y, Romand J, et al. Long-term prognosis after acute kidney injury requiring renal replacement therapy. Nephrol Dial Transplant 2009; 24:2186-2189.
61. Basile DP, Donohoe D, Roethe K, Osborn JL. Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol 2001; 281:F887-F899.
62. Pechman KR, De Miguel C, Lund H, et al. Recovery from renal ischemiareperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol 2009; 297:R1358-R1363.
63. Askenazi DJ, Feig DI, Graham NM, et al. 3-5 year longitudinal follow-up of pediatric patients after acute renal failure. Kidney Int 2006; 69:184-189. (Pubitemid 43117757)