메뉴 건너뛰기




Volumn 29, Issue 3, 2013, Pages 299-304

TGR5 in cholangiocytes

Author keywords

apoptosis; bile acids; choleresis; G protein coupled receptor; proliferation

Indexed keywords

BICARBONATE; CYCLIC AMP; FAS ANTIGEN; G PROTEIN COUPLED RECEPTOR; OBETICHOLIC ACID; TAUROCHOLIC ACID; TAUROLITHOCHOLIC ACID; TGR PROTEIN; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

EID: 84876290819     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32835f3f14     Document Type: Review
Times cited : (38)

References (77)
  • 1
    • 50249180215 scopus 로고    scopus 로고
    • Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
    • Hofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 2008; 65:2461-2483.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2461-2483
    • Hofmann, A.F.1    Hagey, L.R.2
  • 3
    • 48749113401 scopus 로고    scopus 로고
    • Targeting bile-acid signalling for metabolic diseases
    • Thomas C, Pellicciari R, Pruzanski M, et al. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008; 7:678-693.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 678-693
    • Thomas, C.1    Pellicciari, R.2    Pruzanski, M.3
  • 4
    • 33645738747 scopus 로고    scopus 로고
    • Endocrine functions of bile acids
    • Houten SM, Watanabe M, Auwerx J. Endocrine functions of bile acids. EMBO J 2006; 25:1419-1425.
    • (2006) EMBO J , vol.25 , pp. 1419-1425
    • Houten, S.M.1    Watanabe, M.2    Auwerx, J.3
  • 5
    • 84868360297 scopus 로고    scopus 로고
    • Perspective: TGR5 (Gpbar-1) in liver physiology and disease
    • Keitel V, Häussinger D. Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin Res Hepatol Gastroenterol 2012; 36:412-419.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 412-419
    • Keitel, V.1    Häussinger, D.2
  • 6
    • 85055815953 scopus 로고    scopus 로고
    • Bile acid signaling in the liver and the biliary tree
    • Häussinger D, Keitel V, Kubitz R, editors, Berlin: DeGruyter Publishing
    • Häussinger D, Reinehr R, Keitel V. Bile acid signaling in the liver and the biliary tree. In: Häussinger D, Keitel V, Kubitz R, editors. Hepatobiliary transport in health and disease. Berlin: DeGruyter Publishing; 2012. pp. 85-102.
    • (2012) Hepatobiliary Transport in Health and Disease , pp. 85-102
    • Häussinger, D.1    Reinehr, R.2    Keitel, V.3
  • 7
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • Kalaany NY, Mangelsdorf DJ. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006; 68:159-191.
    • (2006) Annu Rev Physiol , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 8
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89:147-191.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 9
    • 0033591297 scopus 로고    scopus 로고
    • Identification of a nuclear receptor for bile acids
    • Makishima M, Okamoto AY, Repa JJ, et al. Identification of a nuclear receptor for bile acids. Science 1999; 284:1362-1365.
    • (1999) Science , vol.284 , pp. 1362-1365
    • Makishima, M.1    Okamoto, A.Y.2    Repa, J.J.3
  • 10
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: Natural ligands for an orphan nuclear receptor
    • Parks DJ, Blanchard SG, Bledsoe RK, et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999; 284:1365-1368.
    • (1999) Science , vol.284 , pp. 1365-1368
    • Parks, D.J.1    Blanchard, S.G.2    Bledsoe, R.K.3
  • 11
    • 0035853165 scopus 로고    scopus 로고
    • The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    • Staudinger JL, Goodwin B, Jones SA, et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 2001; 98:3369-3374.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3369-3374
    • Staudinger, J.L.1    Goodwin, B.2    Jones, S.A.3
  • 12
    • 0035853057 scopus 로고    scopus 로고
    • An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
    • Xie W, Radominska-Pandya A, Shi Y, et al. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 2001; 98:3375-3380.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3375-3380
    • Xie, W.1    Radominska-Pandya, A.2    Shi, Y.3
  • 13
    • 0038713221 scopus 로고    scopus 로고
    • The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells
    • Gascon-Barre M, Demers C, Mirshahi A, et al. The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Hepatology 2003; 37:1034-1042.
    • (2003) Hepatology , vol.37 , pp. 1034-1042
    • Gascon-Barre, M.1    Demers, C.2    Mirshahi, A.3
  • 14
    • 61449258999 scopus 로고    scopus 로고
    • Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes
    • Han S, Chiang JY. Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. Drug Metab Dispos 2009; 37:469-478.
    • (2009) Drug Metab Dispos , vol.37 , pp. 469-478
    • Han, S.1    Chiang, J.Y.2
  • 15
    • 0037123667 scopus 로고    scopus 로고
    • Vitamin D receptor as an intestinal bile acid sensor
    • Makishima M, Lu TT, Xie W, et al. Vitamin D receptor as an intestinal bile acid sensor. Science 2002; 296:1313-1316.
    • (2002) Science , vol.296 , pp. 1313-1316
    • Makishima, M.1    Lu, T.T.2    Xie, W.3
  • 16
    • 0003269455 scopus 로고    scopus 로고
    • A G protein-coupled receptor responsive to bile acids
    • Kawamata Y, Fujii R, Hosoya M, et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003; 278:9435-9440.
    • (2003) J Biol Chem , vol.278 , pp. 9435-9440
    • Kawamata, Y.1    Fujii, R.2    Hosoya, M.3
  • 17
    • 0036432845 scopus 로고    scopus 로고
    • Identification of membrane-type receptor for bile acids (M-BAR)
    • Maruyama T, Miyamoto Y, Nakamura T, et al. Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 2002; 298:714-719.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 714-719
    • Maruyama, T.1    Miyamoto, Y.2    Nakamura, T.3
  • 18
    • 84155194947 scopus 로고    scopus 로고
    • Conjugated bile acids activate the sphingo-sine-1-phosphate receptor 2 in primary rodent hepatocytes
    • Studer E, Zhou X, Zhao R, et al. Conjugated bile acids activate the sphingo-sine-1-phosphate receptor 2 in primary rodent hepatocytes. Hepatology 2012; 55:267-276.
    • (2012) Hepatology , vol.55 , pp. 267-276
    • Studer, E.1    Zhou, X.2    Zhao, R.3
  • 19
    • 7644243343 scopus 로고    scopus 로고
    • Involvement of the Src family kinase yes in bile salt-induced apoptosis
    • Reinehr R, Becker S, Wettstein M, Häussinger D. Involvement of the Src family kinase yes in bile salt-induced apoptosis. Gastroenterology 2004; 127:1540-1557.
    • (2004) Gastroenterology , vol.127 , pp. 1540-1557
    • Reinehr, R.1    Becker, S.2    Wettstein, M.3    Häussinger, D.4
  • 20
    • 28844489800 scopus 로고    scopus 로고
    • Bile salt-induced apoptosis involves NADPH oxidase isoform activation
    • Reinehr R, Becker S, Keitel V, et al. Bile salt-induced apoptosis involves NADPH oxidase isoform activation. Gastroenterology 2005; 129:2009-2031.
    • (2005) Gastroenterology , vol.129 , pp. 2009-2031
    • Reinehr, R.1    Becker, S.2    Keitel, V.3
  • 21
    • 33846595768 scopus 로고    scopus 로고
    • Hydrophobic bile salts trigger ceramide formation through endosomal acidification
    • Becker S, Reinehr R, Grether-Beck S, et al. Hydrophobic bile salts trigger ceramide formation through endosomal acidification. Biol Chem 2007; 388:185-196.
    • (2007) Biol Chem , vol.388 , pp. 185-196
    • Becker, S.1    Reinehr, R.2    Grether-Beck, S.3
  • 22
    • 2542466068 scopus 로고    scopus 로고
    • Molecular aspects of medicine: From experimental to clinical hepatology
    • Häussinger D, Kubitz R, Reinehr R, et al. Molecular aspects of medicine: from experimental to clinical hepatology. Mol Aspects Med 2004; 25:221-360.
    • (2004) Mol Aspects Med , vol.25 , pp. 221-360
    • Häussinger, D.1    Kubitz, R.2    Reinehr, R.3
  • 23
    • 3042594002 scopus 로고    scopus 로고
    • Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis
    • Häussinger D, Kurz AK, Wettstein M, et al. Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. Gastroen-terology 2003; 124:1476-1487.
    • (2003) Gastroen-terology , vol.124 , pp. 1476-1487
    • Häussinger, D.1    Kurz, A.K.2    Wettstein, M.3
  • 24
    • 0036241214 scopus 로고    scopus 로고
    • Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner
    • Graf D, Kurz AK, Fischer R, et al. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Gastroenterology 2002; 122:1411-1427.
    • (2002) Gastroenterology , vol.122 , pp. 1411-1427
    • Graf, D.1    Kurz, A.K.2    Fischer, R.3
  • 25
    • 0034910937 scopus 로고    scopus 로고
    • Tauroursodeoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats
    • Kurz AK, Graf D, Schmitt M, et al. Tauroursodeoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 2001; 121:407-419.
    • (2001) Gastroenterology , vol.121 , pp. 407-419
    • Kurz, A.K.1    Graf, D.2    Schmitt, M.3
  • 26
    • 0030829597 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycho-late in rat liver
    • Schliess F, Kurz AK, vom Dahl S, Häussinger D. Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycho-late in rat liver. Gastroenterology 1997; 113:1306-1314.
    • (1997) Gastroenterology , vol.113 , pp. 1306-1314
    • Schliess, F.1    Kurz, A.K.2    Vom Dahl, S.3    Häussinger, D.4
  • 27
    • 41149144697 scopus 로고    scopus 로고
    • Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships, and molecular modeling studies
    • Sato H, Macchiarulo A, Thomas C, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem 2008; 51:1831-1841.
    • (2008) J Med Chem , vol.51 , pp. 1831-1841
    • Sato, H.1    MacChiarulo, A.2    Thomas, C.3
  • 28
    • 78649386642 scopus 로고    scopus 로고
    • The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
    • Keitel V, Görg B, Bidmon HJ, et al. The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia 2010; 58:1794-1805.
    • (2010) Glia , vol.58 , pp. 1794-1805
    • Keitel, V.1    Görg, B.2    Bidmon, H.J.3
  • 29
    • 33751066787 scopus 로고    scopus 로고
    • Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
    • Maruyama T, Tanaka K, Suzuki J, et al. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. J Endocrinol 2006; 191:197-205.
    • (2006) J Endocrinol , vol.191 , pp. 197-205
    • Maruyama, T.1    Tanaka, K.2    Suzuki, J.3
  • 30
    • 33748757234 scopus 로고    scopus 로고
    • Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
    • Vassileva G, Golovko A, Markowitz L, et al. Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem J 2006; 398:423-430.
    • (2006) Biochem J , vol.398 , pp. 423-430
    • Vassileva, G.1    Golovko, A.2    Markowitz, L.3
  • 31
    • 80055090450 scopus 로고    scopus 로고
    • The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
    • Cipriani S, Mencarelli A, Chini MG, et al. The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS One 2011; 6:e25637.
    • (2011) PLoS One , vol.6
    • Cipriani, S.1    Mencarelli, A.2    Chini, M.G.3
  • 32
    • 77953352917 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    • Poole DP, Godfrey C, Cattaruzza F, et al. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil 2010; 22:814-825.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 814-825
    • Poole, D.P.1    Godfrey, C.2    Cattaruzza, F.3
  • 33
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009; 10:167-177.
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 34
    • 84871304988 scopus 로고    scopus 로고
    • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
    • Alemi F, Poole DP, Chiu J, et al. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 2013; 144:145-154.
    • (2013) Gastroenterology , vol.144 , pp. 145-154
    • Alemi, F.1    Poole, D.P.2    Chiu, J.3
  • 35
    • 33947383769 scopus 로고    scopus 로고
    • The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
    • Keitel V, Reinehr R, Gatsios P, et al. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 2007; 45:695-704.
    • (2007) Hepatology , vol.45 , pp. 695-704
    • Keitel, V.1    Reinehr, R.2    Gatsios, P.3
  • 36
    • 44649092024 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor TGR5 in Kupffer cells
    • Keitel V, Donner M, Winandy S, et al. Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem Biophys Res Commun 2008; 372:78-84.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 78-84
    • Keitel, V.1    Donner, M.2    Winandy, S.3
  • 37
    • 70349255713 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
    • Keitel V, Cupisti K, Ullmer C, et al. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009; 50:861-870.
    • (2009) Hepatology , vol.50 , pp. 861-870
    • Keitel, V.1    Cupisti, K.2    Ullmer, C.3
  • 38
    • 77954569180 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
    • Keitel V, Ullmer C, Häussinger D. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biol Chem 2010; 391:785-789.
    • (2010) Biol Chem , vol.391 , pp. 785-789
    • Keitel, V.1    Ullmer, C.2    Häussinger, D.3
  • 39
    • 79959503376 scopus 로고    scopus 로고
    • TGR5 in the biliary tree
    • Keitel V, Häussinger D. TGR5 in the biliary tree. Dig Dis 2011; 29:45-47.
    • (2011) Dig Dis , vol.29 , pp. 45-47
    • Keitel, V.1    Häussinger, D.2
  • 40
    • 77956276608 scopus 로고    scopus 로고
    • Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels
    • Lavoie B, Balemba OB, Godfrey C, et al. Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. J Physiol 2010; 588:3295-3305.
    • (2010) J Physiol , vol.588 , pp. 3295-3305
    • Lavoie, B.1    Balemba, O.B.2    Godfrey, C.3
  • 41
    • 79957663467 scopus 로고    scopus 로고
    • The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
    • Li T, Holmstrom SR, Kir S, et al. The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol Endocrinol 2011; 25:1066-1071.
    • (2011) Mol Endocrinol , vol.25 , pp. 1066-1071
    • Li, T.1    Holmstrom, S.R.2    Kir, S.3
  • 42
    • 0019984161 scopus 로고
    • Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum
    • Angelin B, Bjorkhem I, Einarsson K, Ewerth S. Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum. J Clin Invest 1982; 70:724-731.
    • (1982) J Clin Invest , vol.70 , pp. 724-731
    • Angelin, B.1    Bjorkhem, I.2    Einarsson, K.3    Ewerth, S.4
  • 43
    • 0030573975 scopus 로고    scopus 로고
    • Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: Evidence that litho-cholic acid does not down regulate the hepatic cholesterol 7 alpha-hydro-xylase activity in gallstone patients
    • Einarsson K, Alvelius G, Hillebrant CG, et al. Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: evidence that litho-cholic acid does not down regulate the hepatic cholesterol 7 alpha-hydro-xylase activity in gallstone patients. Biochim Biophys Acta 1996; 1317:19-26.
    • (1996) Biochim Biophys Acta , vol.1317 , pp. 19-26
    • Einarsson, K.1    Alvelius, G.2    Hillebrant, C.G.3
  • 44
    • 0028861289 scopus 로고
    • Regulation of bile acid synthesis in the rat: Relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids
    • Fukushima K, Ichimiya H, Higashijima H, et al. Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids. J Lipid Res 1995; 36:315-321.
    • (1995) J Lipid Res , vol.36 , pp. 315-321
    • Fukushima, K.1    Ichimiya, H.2    Higashijima, H.3
  • 45
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • Pols TW, Nomura M, Harach T, et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 2011; 14:747-757.
    • (2011) Cell Metab , vol.14 , pp. 747-757
    • Pols, T.W.1    Nomura, M.2    Harach, T.3
  • 46
    • 80053308007 scopus 로고    scopus 로고
    • The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice
    • Wang YD, Chen WD, Yu D, et al. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice. Hepatology 2011; 54:1421-1432.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.D.1    Chen, W.D.2    Yu, D.3
  • 47
    • 33745684373 scopus 로고    scopus 로고
    • Bile acid interactions with cholangiocytes
    • Xia X, Francis H, Glaser S, et al. Bile acid interactions with cholangiocytes. World J Gastroenterol 2006; 12:3553-3563.
    • (2006) World J Gastroenterol , vol.12 , pp. 3553-3563
    • Xia, X.1    Francis, H.2    Glaser, S.3
  • 48
    • 79956088562 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5as an emerging target in metabolism and inflammation
    • Pols TW, Noriega LG, Nomura M, et al. The bile acid membrane receptor TGR5as an emerging target in metabolism and inflammation. JHepatol 2011; 54:1263-1272.
    • (2011) JHepatol , vol.54 , pp. 1263-1272
    • Pols, T.W.1    Noriega, L.G.2    Nomura, M.3
  • 49
    • 77957940106 scopus 로고    scopus 로고
    • The biliary HCO(3)(-) umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    • Beuers U, Hohenester S, de Buy Wenniger LJ, et al. The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 2010; 52:1489-1496.
    • (2010) Hepatology , vol.52 , pp. 1489-1496
    • Beuers, U.1    Hohenester, S.2    De Buy Wenniger, L.J.3
  • 50
    • 84155175630 scopus 로고    scopus 로고
    • - umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
    • - umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 2012; 55:173-183.
    • (2012) Hepatology , vol.55 , pp. 173-183
    • Hohenester, S.1    Wenniger, L.M.2    Paulusma, C.C.3
  • 51
    • 17944371738 scopus 로고    scopus 로고
    • Secretin activation of the apical Na-dependent bile acid transporter is associated with cholehepatic shunting in rats
    • Alpini G, Glaser S, Baiocchi L, et al. Secretin activation of the apical Na-dependent bile acid transporter is associated with cholehepatic shunting in rats. Hepatology 2005; 41:1037-1045.
    • (2005) Hepatology , vol.41 , pp. 1037-1045
    • Alpini, G.1    Glaser, S.2    Baiocchi, L.3
  • 52
    • 0033852384 scopus 로고    scopus 로고
    • Forskolin-induced apical membrane insertion of virally expressed, epitope-tagged CFTR in polarized MDCK cells
    • Howard M, Jiang X, Stolz DB, et al. Forskolin-induced apical membrane insertion of virally expressed, epitope-tagged CFTR in polarized MDCK cells. Am J Physiol Cell Physiol 2000; 279:C375-C382.
    • (2000) Am J Physiol Cell Physiol , vol.279
    • Howard, M.1    Jiang, X.2    Stolz, D.B.3
  • 53
    • 73249142867 scopus 로고    scopus 로고
    • Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
    • Pellicciari R, Gioiello A, Macchiarulo A, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem 2009; 52:7958-7961.
    • (2009) J Med Chem , vol.52 , pp. 7958-7961
    • Pellicciari, R.1    Gioiello, A.2    MacChiarulo, A.3
  • 54
    • 0030760489 scopus 로고    scopus 로고
    • Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes
    • Alpini G, Glaser S, Robertson W, et al. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. Am J Physiol 1997; 273:G518-G529.
    • (1997) Am J Physiol , vol.273
    • Alpini, G.1    Glaser, S.2    Robertson, W.3
  • 55
    • 0032899948 scopus 로고    scopus 로고
    • Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid-regulated ductal secretion
    • Alpini G, Glaser SS, Ueno Y, et al. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology 1999; 116:179-186.
    • (1999) Gastroenterology , vol.116 , pp. 179-186
    • Alpini, G.1    Glaser, S.S.2    Ueno, Y.3
  • 56
    • 0347361545 scopus 로고    scopus 로고
    • Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95
    • Reinehr R, Häussinger D. Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95. Gastroenterology 2004; 126:249-262.
    • (2004) Gastroenterology , vol.126 , pp. 249-262
    • Reinehr, R.1    Häussinger, D.2
  • 57
    • 84871242636 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 (Gpbar-1) is highly expressed in intrahepatic cholangiocarcinoma
    • [abstract]
    • Keitel V, Reinehr R, Reich M, et al. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is highly expressed in intrahepatic cholangiocarcinoma. Hepatology 2011; 54. [abstract].
    • (2011) Hepatology , pp. 54
    • Keitel, V.1    Reinehr, R.2    Reich, M.3
  • 58
    • 84873294643 scopus 로고    scopus 로고
    • The deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically-induced liver carcino-genesis
    • Chen WD, Yu D, Forman BM, et al. The deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically-induced liver carcino-genesis. Hepatology 2013; 57:656-666.
    • (2013) Hepatology , vol.57 , pp. 656-666
    • Chen, W.D.1    Yu, D.2    Forman, B.M.3
  • 59
    • 77952562273 scopus 로고    scopus 로고
    • Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
    • Vassileva G, Hu W, Hoos L, et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. J Endocrinol 2010; 205:225-232.
    • (2010) J Endocrinol , vol.205 , pp. 225-232
    • Vassileva, G.1    Hu, W.2    Hoos, L.3
  • 60
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008; 40:1319-1323.
    • (2008) Nat Genet , vol.40 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 61
    • 77249164222 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis
    • Karlsen TH, Franke A, Melum E, et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010; 138:1102-1111.
    • (2010) Gastroenterology , vol.138 , pp. 1102-1111
    • Karlsen, T.H.1    Franke, A.2    Melum, E.3
  • 62
    • 77957877682 scopus 로고    scopus 로고
    • Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
    • Hov JR, Keitel V, Laerdahl JK, et al. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS One 2010; 5:e12403.
    • (2010) PLoS One , vol.5
    • Hov, J.R.1    Keitel, V.2    Laerdahl, J.K.3
  • 63
    • 0030012966 scopus 로고    scopus 로고
    • Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene
    • Van Nieuwkerk CM, Elferink RP, Groen AK, et al. Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 1996; 111:165-171.
    • (1996) Gastroenterology , vol.111 , pp. 165-171
    • Van Nieuwkerk, C.M.1    Elferink, R.P.2    Groen, A.K.3
  • 64
    • 80053334403 scopus 로고    scopus 로고
    • -/-) mouse cholangiopathy model by promoting biliary HCO output
    • -/-) mouse cholangiopathy model by promoting biliary HCO output. Hepatology 2011; 54:1303-1312.
    • (2011) Hepatology , vol.54 , pp. 1303-1312
    • Baghdasaryan, A.1    Claudel, T.2    Gumhold, J.3
  • 65
    • 25144474552 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005; 353:1261-1273.
    • (2005) N Engl J Med , vol.353 , pp. 1261-1273
    • Kaplan, M.M.1    Gershwin, M.E.2
  • 66
    • 77951634696 scopus 로고    scopus 로고
    • Primary biliary cirrhosis: A 2010 update
    • Poupon R. Primary biliary cirrhosis: a 2010 update. J Hepatol 2010; 52:745-758.
    • (2010) J Hepatol , vol.52 , pp. 745-758
    • Poupon, R.1
  • 67
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • Medina JF, Martinez A, Vazquez JJ, Prieto J. Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatol-ogy 1997; 25:12-17.
    • (1997) Hepatol-ogy , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez, A.2    Vazquez, J.J.3    Prieto, J.4
  • 68
    • 0033033458 scopus 로고    scopus 로고
    • Assessment of biliary bicarbonate secretion in humans by positron emission tomography
    • Prieto J, Garcia N, Marti-Climent JM, et al. Assessment of biliary bicarbonate secretion in humans by positron emission tomography. Gastroenterology 1999; 117:167-172.
    • (1999) Gastroenterology , vol.117 , pp. 167-172
    • Prieto, J.1    Garcia, N.2    Marti-Climent, J.M.3
  • 69
    • 79959523283 scopus 로고    scopus 로고
    • Role ofthe anion exchanger2 inthe pathogenesis and treatmentof primary biliary cirrhosis
    • Medina JF. Role ofthe anion exchanger2 inthe pathogenesis and treatmentof primary biliary cirrhosis. Dig Dis 2011; 29:103-112.
    • (2011) Dig Dis , vol.29 , pp. 103-112
    • Medina, J.F.1
  • 70
    • 84876290143 scopus 로고    scopus 로고
    • 952 Long-term (LT) therapy of a farnesoid X receptor (FXR) agonist obeticholic acid (OCA) maintains biochemical response in primary biliary cirrhosis (PBC)
    • [abstract]
    • Hirschfield G, Kowdley K, Mason A, et al. 952 Long-term (LT) therapy of a farnesoid X receptor (FXR) agonist obeticholic acid (OCA) maintains biochemical response in primary biliary cirrhosis (PBC). J Hepatol 2012; 56:S372. [abstract].
    • (2012) J Hepatol , vol.56
    • Hirschfield, G.1    Kowdley, K.2    Mason, A.3
  • 71
    • 77955334203 scopus 로고    scopus 로고
    • 2 Farnesoid-X receptor agonists: A new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid
    • [abstract]
    • Mason A, Luketic V, Lindor K, et al. 2 Farnesoid-X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid. J Hepatol 2010; 52:S1-S2. [abstract].
    • (2010) J Hepatol , vol.52
    • Mason, A.1    Luketic, V.2    Lindor, K.3
  • 72
    • 84868698756 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action
    • doi: 10.1016/S2210-7401:-3.
    • Poupon R. Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action. Clin Res Hepatol Gastroenterol 2012; 36 (Suppl. 1):S3-S12; doi: 10.1016/S2210-7401:-3.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , Issue.SUPPL. 1
    • Poupon, R.1
  • 73
    • 77957242451 scopus 로고    scopus 로고
    • Functional characterization of the semisyn-thetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist
    • Rizzo G, Passeri D, De FF, et al. Functional characterization of the semisyn-thetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist. Mol Pharmacol 2010; 78:617-630.
    • (2010) Mol Pharmacol , vol.78 , pp. 617-630
    • Rizzo, G.1    Passeri D.De, F.F.2
  • 74
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment
    • Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008; 48:308-321.
    • (2008) Hepatology , vol.48 , pp. 308-321
    • Blechacz, B.1    Gores, G.J.2
  • 75
    • 11244335567 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Molecular targeting strategies for chemo-prevention and therapy
    • Sirica AE. Cholangiocarcinoma: molecular targeting strategies for chemo-prevention and therapy. Hepatology 2005; 41:5-15.
    • (2005) Hepatology , vol.41 , pp. 5-15
    • Sirica, A.E.1
  • 76
    • 77149120776 scopus 로고    scopus 로고
    • Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
    • Hong J, Behar J, Wands J, et al. Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma. Gut 2010; 59:170-180.
    • (2010) Gut , vol.59 , pp. 170-180
    • Hong, J.1    Behar, J.2    Wands, J.3
  • 77
    • 33846345695 scopus 로고    scopus 로고
    • Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases ingastriccarcinomacells
    • Yasuda H, Hirata S, Inoue K, et al. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases ingastriccarcinomacells. Biochem Biophys Res Commun 2007;354:154-159.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 154-159
    • Yasuda, H.1    Hirata, S.2    Inoue, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.