Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS

Gynecologic Oncology

Volumn 129, Issue 2, 2013, Pages 425-432

  Yoshioka, Takashi ^a   Yogosawa, Shingo ^a   Yamada, Takeshi ^a   Kitawaki, Jo ^a   Sakai, Toshiyuki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Apoptosis; Bim; HDAC inhibitor; PI3K inhibitor; ROS

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 6 CHLOROMETHYL 2',7' DICHLORODIHYDROFLUORESCEIN DIACETATE; BIM PROTEIN; CASPASE; DICHLORODIHYDROFLUORESCEIN DIACETATE; HISTONE DEACETYLASE INHIBITOR; OBP 801; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE; COLONY FORMATION; CONTROLLED STUDY; DRUG POTENTIATION; ENDOMETRIUM CARCINOMA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG SYNERGISM; ENDOMETRIAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; HISTONE DEACETYLASE INHIBITORS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MORPHOLINES; PEPTIDES, CYCLIC; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84876280942     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2013.02.008     Document Type: Article

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