Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell line

Clinical Cancer Research

Volumn 8, Issue 6, 2002, Pages 1940-1947

  Wang, Qingding ^a   Li, Nan ^a   Wang, Xiaofu ^a   Kim, Myung M ^a   Evers, B Mark ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BUTYRIC ACID; CASPASE 3; CASPASE 9; DNA FRAGMENT; FLUOROURACIL; GEMCITABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; TUMOR GROWTH; XENOGRAFT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BUTYRATES; CASPASE 3; CASPASE 9; CASPASES; DRUG COMBINATIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; POLY(ADP-RIBOSE) POLYMERASES; TUMOR CELLS, CULTURED;

EID: 0036278686     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Cancer statistics, 2000
2. Colorectal cancer screening and follow-up
3. The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors
4. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons
5. Wortmannin causes mistargeting of procathepsin D. Evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes
6. Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN
7. Synthesis and function of 3-phosphorylated inositol lipids
8. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
9. Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
10. A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110α) in de novo DNA synthesis of human colon carcinoma cells
11. Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement
12. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
13. Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase
14. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
15. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
16. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation
17. Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation
18. Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation
19. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: Implications for the possible role of dietary fibre in the prevention of large-bowel cancer
20. Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21Waf1/Cip1 and p27Kip1
21. Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells
22. Butyrate inhibits colon carcinoma cell growth through two distinct pathways
23. Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells
24. Butyrate inhibits seeding and growth of colorectal metastases to the liver in mice
25. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
26. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice
27. Down-regulation of mitogen-activated protein kinases in human colon cancers
28. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
29. Induction of apoptosis in human gastric cancer by sodium butyrate
30. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
31. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
32. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
33. Proteases to die for
34. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells
35. Resistance to 5-fluorouracil
36. Clinical and preclinical activity of 2′, 2′-difluorodeoxycytidine (gemcitabine)
37. Gemcitabine: Current status of Phase I and II trials
38. Overexpression and overactivation of Akt in thyroid carcinoma
39. In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin
40. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
41. Effects of retinoic acid and sodium butyrate on gene expression, histone acetylation, and inhibition of proliferation of melanoma cells
42. Blottiere Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: Induction of cyclin D3 and p21 expression
43. Activity of glycogen synthase kinase-3β is down-regulated during transient differentiation of human colon cancer HT-29 cells
44. Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors
45. Inhibition of phosphoinositide 3-kinase-related kinases by the radiosensitizing agent wortmannin
46. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
47. A phosphatidylinositol 3-kinase inhibitor, wortmannin, induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
48. The PI 3-kinase/Akt signaling pathway delivers an antiapoptotic signal
49. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
50. Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts
51. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells
52. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways