Skin mild hypoxia enhances killing of UVB-damaged keratinocytes through reactive oxygen species-mediated apoptosis requiring Noxa and Bim

Free Radical Biology and Medicine

Volumn 52, Issue 6, 2012, Pages 1111-1120

  Nys, Kris ^a   Maes, Hannelore ^a   Andrei, Graciela ^a   Snoeck, Robert ^a   Garmyn, Maria ^a   Agostinis, Patrizia ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Apoptosis; Keratinocytes; MAPK kinases; Melanocytes; Mild hypoxia; Reactive oxygen species (ROS); UVB

Indexed keywords

BIM PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN NOXA; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL HYPOXIA; CELL KILLING; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; MELANOCYTE; MELANOMA CELL; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION INJURY; SKIN CARCINOGENESIS; SKIN INJURY; ULTRAVIOLET B RADIATION;

ANOXIA; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CYTOPROTECTION; HOMEOSTASIS; HUMANS; KERATINOCYTES; MELANOCYTES; MELANOMA; MEMBRANE PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SKIN; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 84857234692     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.12.017     Document Type: Article

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