Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells

Food and Chemical Toxicology

Volumn 49, Issue 8, 2011, Pages 1737-1744

  Cho, Jung Hoon ^a   Lee, Jong Gyu ^a   Yang, Yeong In ^a   Kim, Ji Hyun ^a   Ahn, Ji Hye ^a   Baek, Nam In ^a   Lee, Kyung Tae ^a   Choi, Jung Hye ^a  

^a Kyung Hee University   (South Korea)

Author keywords

ATM; Chk2; Endometrial cancer; Eupatilin; G2 M arrest; P21

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 2; CISPLATIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; EUPATILIN; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN CDC2; PROTEIN CDC25C; PROTEIN KINASE B; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION;

ANTINEOPLASTIC AGENTS; ARTEMISIA; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOMETRIUM; FEMALE; FLAVONOIDS; FLOW CYTOMETRY; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN-SERINE-THREONINE KINASES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

ARTEMISIA PRINCEPS;

EID: 79958704215     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.04.019     Document Type: Article

References (40)

1. Aalders J.G., Abeler V., Kolstad P. Recurrent adenocarcinoma of the endometrium: A clinical and histopathological study of 379 patients. Gynecol. Oncol. 1984, 17:85-103.
2. Ando T., Kawabe T., Ohara H., Ducommun B., Itoh M., Okamoto T. Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J. Biol. Chem. 2001, 276:42971-42977.
3. Avila M.A., Velasco J.A., Cansado J., Notario V. Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res. 1994, 54:2424-2428.
4. Bates S., Ryan K.M., Phillips A.C., Vousden K.H. Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression. Oncogene 1998, 17:1691-1703.
5. Brosh R., Rotter V. When mutants gain new powers: News from the mutant p53 field. Nat. Rev. Cancer 2009, 9:701-713.
6. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282:1497-1501.
7. Buolamwini J.K. Cell cycle molecular targets in novel anticancer drug discovery. Curr. Pharm. Des. 2000, 6:379-392.
8. Choi E.J., Oh H.M., Wee H., Choi C.S., Choi S.C., Kim K.H., Han W.C., Oh T.Y., Kim S.H., Jun C.D. Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells. Differentiation 2009, 77:412-423.
9. Collins K., Jacks T., Pavletich N.P. The cell cycle and cancer. Proc. Natl Acad. Sci. USA 1997, 94:2776-2778.
10. Creasman W.T., Odicino F., Maisonneuve P., Beller U., Benedet J.L., Heintz A.P., Ngan H.Y., Sideri M., Pecorelli S. Carcinoma of the corpus uteri. J. Epidemiol. Biostat. 2001, 6:47-86.
11. Deng C., Zhang P., Harper J.W., Elledge S.J., Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995, 82:675-684.
12. Fan S., Smith M.L., Rivet D.J., Duba D., Zhan Q., Kohn K.W., Fornace A.J., O'Connor P.M. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res. 1995, 55:1649-1654.
13. Garai J., Molnar V., Varga T., Koppan M., Torok A., Bodis J. Endometriosis: Harmful survival of an ectopic tissue. Front. Biosci. 2006, 11:595-619.
14. Hajduch M., Havlieek L., Vesely J., Novotny R., Mihal V., Strnad M. Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs. Adv. Exp. Med. Biol. 1999, 457:341-353.
15. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
16. Huh K., Kwon T.H., Shin U.S., Kim W.B., Ahn B.O., Oh T.Y., Kim J.A. Inhibitory effects of DA-9601 on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats. J. Ethnopharmacol. 2003, 88:269-273.
17. Jemal A., Siegel R., Ward E., Murray T., Xu J., Thun M.J. Cancer statistics, 2007. CA Cancer J. Clin. 2007, 57:43-66.
18. Kim D.H., Na H.K., Oh T.Y., Kim W.B., Surh Y.J. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. Biochem. Pharmacol. 2004, 68:1081-1087.
19. Kim H.S., Kundu J.K., Lee J.S., Oh T.Y., Na H.K., Surh Y.J. Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis. Nutr. Cancer 2004, 68(Suppl 1):90-97.
20. Kim J.Y., Kim D.Y., Lee Y.S., Lee B.K., Lee K.H., Ro J.Y. DA-9601, Artemisia asiatica herbal extract, ameliorates airway inflammation of allergic asthma in mice. Mol. Cells 2006, 22:104-112.
21. Kim M.J., Kim D.H., Na H.K., Oh T.Y., Shin C.Y., Surh Ph D.P.Y.J. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. J. Environ. Pathol. Toxicol. Oncol. 2005, 24:261-269.
22. Kuo P.L., Hsu Y.L., Cho C.Y. Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol. Cancer Ther. 2006, 5:3209-3221.
23. Medema R.H., Klompmaker R., Smits V.A., Rijksen G. P21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases. Oncogene 1998, 16:431-441.
24. Min S.W., Kim N.J., Baek N.I., Kim D.H. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J. Ethnopharmacol. 2009, 125:497-500.
25. Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y. Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines. Pathol. Res. Pract. 2005, 201:109-115.
26. Navo M.A., Smith J.A., Gaikwad A., Burke T., Brown J., Ramondetta L.M. In vitro evaluation of the growth inhibition and apoptosis effect of mifepristone (RU486) in human Ishikawa and HEC1A endometrial cancer cell lines. Cancer Chemother. Pharmacol. 2008, 62:483-489.
27. Niculescu A.B., Chen X., Smeets M., Hengst L., Prives C., Reed S.I. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 1998, 18:629-643.
28. Nurse P. Universal control mechanism regulating onset of M-phase. Nature 1990, 344:503-508.
29. Oren M., Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harb. Perspect. Biol. 2010, 2:a001107.
30. Ouyang G., Yao L., Ruan K., Song G., Mao Y., Bao S. Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol. Int. 2009, 33:1237-1244.
31. Park E.Y., Lee K.W., Lee H.W., Cho Y.W., Baek N.I., Chung H.G., Jeong T.S., Choi M.S., Lee K.T. The ethanol extract from Artemisia princeps Pampanini induces p53-mediated G1 phase arrest in A172 human neuroblastoma cells. J. Med. Food 2008, 11:237-245.
32. Sanchez Y., Amran D., de Blas E., Aller P. Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem. Pharmacol. 2009, 77:384-396.
33. Seo H.J., Surh Y.J. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Mutat. Res. 2001, 496:191-198.
34. Seol S.Y., Kim M.H., Ryu J.S., Choi M.G., Shin D.W., Ahn B.O. DA-9601 for erosive gastritis: Results of a double-blind placebo-controlled phase III clinical trial. World J. Gastroenterol. 2004, 10:2379-2382.
35. Takai N., Narahara H. Human endometrial and ovarian cancer cells: ZHISTONE deacetylase inhibitors exhibit antiproliferative activity, potently induce cell cycle arrest, and stimulate apoptosis. Curr. Med. Chem. 2007, 14:2548-2553.
36. Vikhanskaya F., Lee M.K., Mazzoletti M., Broggini M., Sabapathy K. Cancer-derived p53 mutants suppress p53-target gene expression-potential mechanism for gain of function of mutant p53. Nucleic Acids Res. 2007, 35:2093-2104.
37. Wei F., Xie Y., Tao L., Tang D. Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation. Cell. Signal. 2010, 22:1783-1789.
38. Wong S.H., Shih R.S., Schoene N.W., Lei K.Y. Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells. Am. J. Physiol. Cell Physiol. 2008, 294:C1342-1349.
39. Yan Y., Black C.P., Cowan K.H. Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 2007, 26:4689-4698.
40. Zhang X., Chen W., Guillermo R., Chandrasekher G., Kaushik R.S., Young A., Fahmy H., Dwivedi C. Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells. BMC Res. Notes 2010, 3:220.