The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

Islets

Volumn 4, Issue 6, 2012, Pages 417-422

  Dahllöf, Mattias S ^a   Christensen, Dan P ^a   Lundh, Morten ^a   Dinarello, Charles A ^b,c   Mascagni, Paolo ^c   Grunnet, Lars G ^a,d   Mandrup Poulsen, Thomas ^a,e  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Talfarmaco   (Italy)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d NOVO NORDISK A S   (Denmark)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Chemokines; Cytokines; Diabetes mellitus; Histone deacetylases; Inflammation

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; GIVINOSTAT; HISTONE H4; HYDROLASE; LYSINE DEACETYLASE; MESSENGER RNA; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 1BETA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL LYSATE; CONTROLLED STUDY; ENZYME INHIBITION; HISTONE ACETYLATION; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PROTEIN PROCESSING; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; CHEMOKINES; CYTOKINES; DIABETES MELLITUS; HISTONE DEACETYLASES; INFLAMMATION;

ANIMALS; CARBAMATES; CHEMOKINE CXCL10; DIABETES MELLITUS; HISTONE DEACETYLASE INHIBITORS; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 84876250667     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.23541     Document Type: Article

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