Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

Diabetologia

Volumn 55, Issue 9, 2012, Pages 2421-2431

  Lundh, M ^a   Christensen, D P ^a   Damgaard Nielsen, M ^a,b   Richardson, S J ^c   Dahllof M S ^a   Skovgaard, T ^b   Berthelsen, J ^b   Dinarello, C A ^d   Stevenazzi, A ^e   Mascagni, P ^e   Grunnet, L G ^a,f   Morgan, N G ^g   Mandrup Poulsen, T ^a,h  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

^c UNIVERSITY OF PLYMOUTH   (United Kingdom)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e Italfarmaco SpA   (Italy)

^f NOVO NORDISK A S   (Denmark)

^g UNIVERSITY OF EXETER   (United Kingdom)

^h KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Autoimmunity; Cytokines; Epigenetics; HDAC; HDAC1; HDAC2; HDAC3; Inflammation; NF B; Type 1 diabetes

Indexed keywords

CXCL2 CHEMOKINE; CYTOKINE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CHILD; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETIC PATIENT; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NEWBORN; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; UPREGULATION; WILD TYPE;

ANIMALS; APOPTOSIS; CHILD; CHILD, PRESCHOOL; CYTOKINES; DIABETES MELLITUS, TYPE 1; FEMALE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; INFANT; INSULIN-SECRETING CELLS; MALE; NF-KAPPA B; PANCREAS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84866080005     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2615-0     Document Type: Article

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