Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 6, 2013, Pages 3776-3786

  Yadav, Sudhir K ^a   Adhikary, Biplab ^a   Bandyopadhyay, Sandip K ^a   Chattopadhyay, Subrata ^b  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Angiogenesis; Gastric ulcer; Indomethacin; Inflammatory modulator; NSAID

Indexed keywords

ACETYLCYSTEINE; ALLYLPYROCATECHOL; CYCLOOXYGENASE RECEPTOR; CYTOKINE; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MISOPROSTOL; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; OMEPRAZOLE; PHENOL; PROSTAGLANDIN; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TROLOX C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; STOMACH PROTECTION; STOMACH ULCER; TUMOR NECROSIS FACTOR ALPHA GENE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CATECHOLS; DISEASE MODELS, ANIMAL; INDOMETHACIN; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MISOPROSTOL; OMEPRAZOLE; OXIDATIVE STRESS; PIPER BETLE; STOMACH ULCER; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84876179547     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.03.013     Document Type: Article

References (57)

1. S.H. Roth Nonsteroidal anti-inflammatory drug gastropathy: we started it, why don't we stop it? J. Rheumatol. 32 2005 1189 1191
2. J.L. Wallace NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies Br. J. Pharmacol. 165 2012 67 74
3. F. Halter, A. Schamassman, B.M. Peskar, and A.S. Tarnawski Cyclooxygenase-2 implications on maintenance of gastric mucosal integrity and ulcer healing: controversies and perspectives Gut 49 2001 443 453
4. J.L. Wallace, C.M. Keenan, and D.N. Granger Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process Am. J. Physiol. 259 1990 G462 G467
5. M.H.L.P. Souza, J.M.S.C. Mota, R.B. Oliveira, and F.Q. Cunha Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration Inflamm. Res. 57 2008 28 33
6. A. Tarnawski, J. Stachura, T.G. Douglass, W.J. Krause, H. Gergely, and I.J. Sarfeh Indomethacin impairs quality of experimental gastric ulcer healing: a quantitative histological and ultrastructural analysis A. Garner, P.E. O'Brien, Mechanisms of Injury, Protection and Repair of the Upper Gastrointestinal Tract 1991 Wiley & Sons Chichester, UK 521 531
7. A.S. Tarnawski Cellular and molecular mechanisms of gastrointestinal ulcer healing Dig. Dis. Sci. 50 Supplement 1 2005 S24 S33
8. P.P. Tak, and G.S. Firestein NF-κB: a key role in inflammatory diseases J. Clin. Invest. 107 2001 7 11
9. A.S. Baldwin Jr. The NF-κB and I-κB proteins: new discoveries and insights Annu. Rev. Immunol. 14 1996 649 681
10. G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912
11. J. Cuschieri, and R.V. Maier Mitogen-activated protein kinase (MAPK) Crit. Care Med. 33 2005 S417 S419
12. S.E. Miederer Will anti-ulcer drugs soon differ only in their side effects? Fortschr. Med. 104 1986 918 920
13. F.K.L. Chan Primer: managing NSAID-induced ulcer complications - balancing gastrointestinal and cardiovascular risks Nat. Clin. Pract. Gastroenterol. Hepatol. 3 2006 563 573
14. K. Biswas, U. Bandyopadhyay, I. Chattopadhyay, A. Varadaraj, E. Ali, and R.K. Banerjee A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical J. Biol. Chem. 278 2003 10993 11001
15. J.S. Rathee, B.S. Patro, S. Mula, S. Gamre, and S. Chattopadhyay Antioxidant activity of Piper betel leaf extract and its constituents J. Agric. Food Chem. 54 2006 9046 9054
16. S. Bhattacharya, D. Banerjee, A.K. Bauri, S. Chattopadhyay, and S.K. Bandyopadhyay Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action World J. Gastroenterol. 13 2007 3705 3713
17. D. Banerjee, S. Bhattacharya, S.K. Bandyopadhyay, and S. Chattopadhyay Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice Dig. Dis. Sci. 53 2008 2868 2877
18. S.K. Yadav, B. Adhikary, B. Maity, S.K. Bandyopadhyay, and S. Chattopadhyay The gastric ulcer healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance Eur. J. Pharmacol. 614 2009 106 113
19. S. Ganguly, S. Mula, S. Chattopadhyay, and M. Chatterjee An ethanol extract of Piper betle Linn mediates its anti inflammatory activity via down regulation of nitric oxide J. Pharm. Pharmacol. 59 2007 711 718
20. D. Sarkar, P. Saha, S. Gamre, S. Bhattacharjee, C. Hariharan, S. Ganguly, R. Sen, G. Mandal, S. Chattopadhyay, S. Majumdar, and M. Chatterjee Anti-inflammatory effect of allylpyrocatechol in LPS induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-κB pathway Int. Immunopharmacol. 8 2008 1264 1271
21. S. Kundu, A. Bala, P. Ghosh, D. Mukhopadhyay, A. Mitra, A. Sarkar, A.K. Bauri, A. Ghosh, S. Chattopadhyay, and M. Chatterjee Attenuation of oxidative stress by allylpyrocatechol in synovial cellular infiltrate of patients with rheumatoid arthritis Free Radic. Res. 45 2011 518 526
22. D. Henry, A. Dobson, and C. Turner Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs Gastroenterology 105 1993 1078 1088
23. S.K. Yadav, B. Adhikary, S. Chand, B. Maity, S.K. Bandyopadhyay, and S. Chattopadhyay Molecular mechanism of indomethacin-induced gastropathy Free Radic. Biol. Med. 52 2012 1175 1187
24. D. Dokmeci, M. Akpolat, N. Aydogu, L. Doganay, and F.N. Turan l-Carnitine inhibits ethanol-induced gastric mucosal injury in rats Pharmacol. Rep. 57 2005 481 488
25. P.P. Bradley, D.A. Priebat, R.D. Christensen, and G. Rothstein Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker J. Invest. Dermatol. 78 1982 206 209
26. H.J. Kim, K.W. Kim, B.P. Yu, and H.Y. Chung The effect of age on cyclooxygenase-2 gene expression: NF-κB activation and IκBα degradation Free Radic. Biol. Med. 28 2000 683 692
27. J. Crespo, A. Cayon, P. Fernandez-Gil, M. Hernandez-Guerra, M. Mayorga, A. Dominguez-Diez, J.C. Fernandez-Escalante, and F. Pons-Romero Gene expression of tumor necrosis factor and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients Hepatology 34 2001 1158 1163
28. T. Yoshikawa, Y. Naito, A. Kishi, T. Tomii, T. Kaneko, S. Iinuma, H. Ichikawa, M. Yasuda, S. Takahashi, and M. Kondo Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats Gut 34 1993 732 737
29. Y.P. Bai, Y.H. Liu, J. Chen, T. Song, Y. You, Z.Y. Tang, Y.J. Li, and G.G. Zhang Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation Biochem. Biophys. Res. Commun. 360 2007 20 26
30. B.M. Peskar, N. Maricic, B. Gretzera, R. Schuligoi, and A. Schmassmann Role of cyclooxygenase-2 in gastric mucosal defense Life Sci. 69 2001 2993 3003
31. J.L. Wallace, A. Bak, W. McKnight, S. Asfaha, K.A. Sharkey, and W.K. MacNaughton Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity Gastroenterology 115 1998 101 109
32. N.V. Chandrasekharan, H. Dai, K.L. Roos, N.K. Evanson, J. Tomsik, T.S. Elton, and D.L. Simmons COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression Proc. Natl. Acad. Sci. U.S.A. 99 2002 13926 13931
33. R. Colucci, L. Antonioli, N. Bernardini, C. Ippolito, C. Segnani, O. Awwad, M. Tuccori, C. Blandizzi, C. Scarpignato, and M. Fornai Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing J. Pharmacol. Exp. Ther. 342 2012 140 149
34. D. Neil, J.O. Boyle, J.D. Morrow, M.K. Williams, C.S. Moskowitz, K. Subbaramaiah, A.J. Dannenberg, and A.J. Duffield-Lillico Levels of prostaglandin E metabolite, the major urinary metabolite of prostaglandin E 2 are increased in smokers Clin. Cancer Res. 11 2005 6087 6093
35. O. Ylikorkala, and U.M. Mäkilä Prostacyclin and thromboxane in gynecology and obstetrics Am. J. Obstet. Gynecol. 152 1985 318 329
36. J.C. Becker, W. Domschke, and T. Pohle Current approaches to prevent NSAID-induced gastropathy - COX selectivity and beyond Br. J. Clin. Pharmacol. 58 2004 587 600
37. K. Takeuchi Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility World J. Gastroenterol. 18 2012 2147 2160
38. N.M. Davies, K.A. Sharkey, S. Asfaha, W.K. MacNaughton, and J.L. Wallace Aspirin causes rapid upregulation of cyclooxygenase-2 expression in the stomach of rats Aliment. Pharmacol. Ther. 11 1997 1101 1108
39. H. Slawik, B. Volk, B. Fiebich, and M. Hüll Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum Neurochem. Int. 45 2004 653 660
40. L.R. Ballou, A.E. Postlethwaite, and A.H. Kang The effect of misoprostol on arachidonic acid mobilization, prostaglandin E(2), production, and IL-1 beta signaling Am. J. Ther. 2 1995 630 636
41. J.L. Goldstein, J.F. Johanson, C.J. Hawkey, L.J. Suchower, and K.A. Brown Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazole Aliment. Pharmacol. Ther. 26 2007 1101 1111
42. C.B. Appleyard, D.M. McCafferty, A.W. Tigley, M.G. Swain, and J.L. Wallace Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence Am. J. Physiol. 270 1996 G42 G48
43. P. Maity, S. Bindu, S. Dey, M. Goyal, A. Alam, C. Pal, K. Mitra, and U. Bandyopadhyay Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa. A novel role of mitochondrial aconitase oxidation J. Biol. Chem. 284 2009 3058 3068
44. E.G. Barrett, C. Johnston, G. Oberdorster, and J.N. Finkelstein Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure Toxicol. Appl. Pharmacol. 158 1999 211 220
45. H.W. Pogrebniak, W. Matthews, and H.I. Pass Chemotherapy amplifies production of tumor necrosis factor Surgery 110 1991 231 237
46. B. Glowinska, M. Urban, J. Peczynska, and B. Florys Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes Metabolism 54 2005 1020 1026
47. R.J. Gryglewski, A. Szczeklik, and M. Wandzilak The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl- leucyl-phenylalanine Biochem. Pharmacol. 36 1987 4209 4213
48. Y. Yoda, K. Amagase, S. Kato, S. Tokioka, M. Murano, K. Kakimoto, H. Nishio, E. Umegaki, K. Takeuchi, and K. Higuchi Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats through induction of heme oxygenase-1 J. Physiol. Pharmacol. 61 2010 287 294
49. Y.J. Lim, T.M. Phan, E.J. Dial, D.Y. Graham, and L.M. Lichtenberger In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin- phosphatidylcholine Digestion 86 2012 171 177
50. R. Colucci, M. Fornai, L. Antonioli, N. Ghisu, M. Tuccori, C. Blandizzi, and M. Del Tacca Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment Dig. Liver Dis. 41 2009 395 405
51. T.R. Koch, A. Petro, M. Darrabie, and E.C. Opara Effects of esomeprazole magnesium on nonsteroidal anti-inflammatory drug gastropathy Dig. Dis. Sci. 50 2005 86 93
52. S. Tsutsumi, T. Gotoh, W. Tomisato, S. Mima, T. Hoshino, H.-J. Hwang, H. Takenaka, T. Tsuchiya, M. Mori, and T. Mizushima Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis Cell Death Differ. 11 2004 1009 1016
53. K. Mitsuyama, O. Tsuruta, Y. Matsui, K. Harada, N. Tomiyasu, A. Suzuki, K. Takaki, J. Masuda, K. Handa, Y. Satoh, B.L. Bennett, A. Toyonaga, and M. Sata Activation of c-Jun N-terminal kinase (JNK) signaling in experimentally induced gastric lesions in rats Br. Soc. Immunol. Clin. Exp. Immunol. 143 2005 24 29
54. V. Ramirez-Alcantara, A. LoGuidice, and U.A. Boelsterli Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy Am. J. Physiol. Gastrointest. Liver Physiol. 297 2009 G990 G998
55. A.W.Y. Hoa, C.K. Wonga, and C.W.K. Lama Tumor necrosis factor-α up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways Immunobiology 213 2008 533 544
56. O.M. Salam, A.A. Sleem, E.A. Omara, and N.S. Hassan Hepatoprotective effects of MP and silymarin on carbon tetrachloride-induced hepatic damage in rats Fundam. Clin. Pharmacol. 23 2009 179 188
57. E. Kitsis, G. Weissmann, and S. Abramson The prostaglandin paradox: additive inhibition of neutrophil function by aspirin-like drugs and the prostaglandin E1 analog misoprostol J. Rheumatol. 18 1991 1461 1465