Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-κB pathway

International Immunopharmacology

Volumn 8, Issue 9, 2008, Pages 1264-1271

  Sarkar, Debjani ^a   Saha, Piu ^b   Gamre, Sunita ^c   Bhattacharjee, Surajit ^d   Hariharan, Chellaram ^e   Ganguly, Sudipto ^b   Sen, Rupashree ^b   Mandal, Goutam ^b   Chattopadhyay, Subrata ^c   Majumdar, Subrata ^d   Chatterjee, Mitali ^b  

^a Department of Zoology ^*  (India)

^b INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^c BHABHA ATOMIC RESEARCH CENTRE   (India)

^d BOSE INSTITUTE   (India)

^e Central Drugs Laboratory India   (India)

Author keywords

Allylpyrocatechol; Anti inflammatory; Nitric oxide; Nuclear factor B; Piper betle

Indexed keywords

ALCOHOL; ALLYLPYROCATECHOL; CATECHOL DERIVATIVE; CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12P40; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME REPRESSION; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PIPER BETLE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CATECHOLS; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; EDEMA; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 46349093408     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.05.003     Document Type: Article

References (37)

1. Ross J.A., Auger M.J., In Burke B., and Lewis C.E. The biology of the macrophage. In: Burke B., and Lewis C.E. (Eds). The macrophage. 2nd ed. (2002), Oxford Medical Publications, Oxford, UK 1-72
2. Zhang X., and Mosser D.M. Macrophage activation by endogenous danger signals. J Pathol 214 (2008) 161-178
3. Mckellar G., Madhok R., and Singh G. The problem with NSAIDs: what data to believe?. Curr Pain Headache Rep 11 (2007) 423-427
4. Chatterjee A., and Pakrashi S.C. The treatise on Indian Medicinal Plants. Publication and Information Directorate, New Delhi 1 (1994) 25-26
5. Owen P.L., Matainaho T., Sirois M., and Johns T. Endothelial cytoprotection from oxidized LDL by some crude Melanesian plant extracts is not related to their antioxidant capacity. J Biochem Mol Toxicol 21 (2007) 231-242
6. Bhattacharya S., Subramanian M., Roychowdhury S., Bauri A.K., Kamat J.P., Chattopadhyay S., et al. Radioprotective property of the ethanolic extract of Piper betel leaf. J Radiat Res 46 (2005) 165-171
7. Nalina T., and Rahim Z.H.A. The crude aqueous extract of Piper betle L and its antibacterial effect towards Streptococcus mutans. Am J Biochem Biotech 3 (2007) 10-15
8. Rahman I., Dutta B.K., and Das T.K. Susceptibility of pathogenic fungi to Piper betle extracts, an in vitro evaluation. Environment and Ecology 23 (2005) 8-11
9. Ganguly S., Mula S., Chattopadhyay S., and Chatterjee M. An ethanol extract of Piper betle Linn. mediates its anti-inflammatory activity via down-regulation of nitric oxide. J Pharm Pharmacol 59 (2007) 711-718
10. Rathee J.S., Patro B.S., Mula S., Gamre S., and Chattopadhyay S. Antioxidant activity of piper betel leaf extract and its constituents. J Agric Food Chem 54 (2006) 9046-9054
11. Rowley D.A., and Benditt E.P. 5-Hydroxytryptamine and histamine as mediators of vascular injury produced by agents which damage mast cells in rats. J Exp Med 103 (1956) 399-412
12. Sarkar D., Dutta A., Das M., Sarkar K., Mandal C., and Chatterjee M. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian J Pharmacol 37 (2005) 371-375
13. Sen R., Bauri A.K., Chattopadhyay S., and Chatterjee M. Antipromastigote activity of the malabaricones of Myristica malabarica (rampatri). Phytother Res 21 (2007) 592-595
14. Hibbs Jr. J.B., Taintor R.R., Vavrin Z., and Rachlin E.M. Nitric oxide: a cyotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157 (1988) 87-94
15. Dikshit M., and Sharma P. Nitric oxide mediated modulation of free radical generation response in the rat polymorphonuclear leukocytes: a flowcytometric study. Methods Cell Sci 24 (2002) 69-76
16. Pan M.H., Lai C.S., Wang Y.J., and Ho C.T. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol 72 (2002) 1293-1303
17. + T cells from a Th2 to a Th1 response. Immunology 109 (2003) 407-414
18. Kang B.Y., Lee S.W., and Kim T.S. Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen activated protein kinase by alpha 2-adrenoceptor agonists. Eur J Pharmacol 467 (2003) 223-231
19. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem 193 (1951) 265-275
20. Lo A.H., Liang Y.C., Lin-Shiau S.Y., Ho C.T., and Lin J.K. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappa B in mouse macrophages. Carcinogenesis 23 (2002) 983-991
21. Saluk-Juszczak J., and Wachowicz B. The proinflammatory activity of lipopolysaccharide. Postepy Biochem. 51 (2005) 280-287
22. Weinberg J.B. Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. Immunol Res 22 (2000) 319-341
23. Chen Z.J. Ubiquitin signaling in the NF-kappa B pathway. Nat Cell Biol 7 (2005) 758-765
24. Bhattacharya S., Banerjee D., Bauri A.K., Chattopadhyay S., and Bandyopadhyay S.K. Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. World J Gastroenterol. 13 (2007) 3705-3713
25. Gryglewski R.J. Molecular mechanisms of inflammation. Eur J Rheumatol Inflamm 4 (1981) 153-159
26. Lo T.N., Almeida A.P., and Beaven M.A. Dextran and carrageenen evoke different inflammatory responses in rat with respect to composition of infiltrates and effect of indomethacin. J Pharmacol Exp Ther 221 (1982) 261-267
27. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 15 (1997) 323-350 Review
28. Andrew P.J., and Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res. 43 (1999) 521-531
29. Liu R.H., and Hotchkiss J.H. Potential genotoxicity of chronically elevated nitric oxide; a review. Mutat Res 339 (1995) 73-89
30. Nguyen T., Brunson D., Crespi C.L., Penman B.W., Wishnok J.S., and Tannenbaum S.R. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci, USA 89 (1992) 3030-3034
31. Pahan K., Sheikh F.G., Liu X., Hilger S., McKinney M., and Petro T.M. Induction of nitric-oxide synthase and activation of NF-kappa B by interleukin-12p40 in microglial cells. J Biol Chem 276 (2001) 7899-7905
32. Ackermann C., and Kavanaugh A. Tumor necrosis factor as a therapeutic target of rheumatologic disease. Expert Opin Ther Targets 11 (2007) 1369-1384 Review
33. Suzuki E., and Umezawa K. Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin. Biomed Pharmacother 60 (2006) 578-586
34. Wang M.T., Honn K.V., and Nie D. Cycloxygenases, prostanoids and tumor progression. Cancer Metastasis Rev 26 (2007) 525-534
35. Cuccurullo C., Fazia M.L., Mezzetti A., and Cipollone F. COX-2 expression in atherosclerosis: the good, the bad or the ugly?. Curr Med Chem 14 (2007) 1595-1605 Review
36. Hseu Y.C., Wu F.Y., Wu J.J., Chen J.Y., Chang W.H., Lu F.J., et al. Anti-inflammatory potential of Antrodia camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-κappaB pathway. Int Immunopharmacol 5 (2005) 1914-1925
37. Baldwin Jr. A. The NF-kappa B and I-kappa B proteins: new discoveries and insights. Annu Rev Immunol 14 (1996) 649-683