The gastric ulcer-healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance

European Journal of Pharmacology

Volumn 614, Issue 1-3, 2009, Pages 106-113

  Yadav, Sudhir K ^a   Adhikary, Biplab ^a   Maity, Biswanath ^a   Bandyopadhyay, Sandip K ^a   Chattopadhyay, Subrata ^b  

^a Dr BC Roy Post Graduate Institute of Basic Medical Sciences   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Arginase; Cytokine; Indomethacin; iNOS; NSAID

Indexed keywords

ALLYLPYROCATECHOL; ARGINASE; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GASTROINTESTINAL AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; NITRILE; OMEPRAZOLE; POLYAMINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ULCER; ULCER HEALING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARGINASE; ARGININE; CATECHOLS; CYTOKINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICE; MUCOUS MEMBRANE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; PEROXIDASE; STOMACH ULCER;

EID: 67349280490     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.04.046     Document Type: Article

References (46)

1. Abbas A.K., Murphy K.M., and Sher A. Functional diversity of helper T lymphocytes. Nature 383 (1996) 787-793
2. Albina J.E., and Henry Jr. W.L. Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway. J. Surg. Res. 50 (1991) 403-409
3. Banerjee D., Bhattacharya S., Bandyopadhyay S.K., and Chattopadhyay S. Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. Dig. Dis. Sci. 53 (2008) 2868-2877
4. Banerjee D., Bauri A.K., Guha R.K., Bandyopadhyay S.K., and Chattopadhyay S. Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. Eur. J. Pharmacol. 578 (2008) 300-312
5. Bhattacharya S., Banerjee D., Bauri A.K., Chattopadhyay S., and Bandyopadhyay S.K. Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin induced stomach ulceration and mechanism of action. World J Gastroenterol. 13 (2007) 3705-3713
6. Bernard A.C., Mistry S.K., Morris Jr. S.M., O Brien W.E., Tsuei B.J., Maley M.E., Shirley L.A., Kearney P.A., Boulanger B.R., and Ochoa J.B. Alterations in arginine metabolic enzymes in trauma. Shock 15 (2001) 215-219
7. Brzozowski T., Konturek P.C., Konturek S.J., Sliwowski Z., Pajdo R., Drozdowicz D., Ptak A., and Hahn E.G. Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microsc. Res. Tech. 43 (2001) 343-353
8. Chan F.K.L. Primer: managing NSAID-induced ulcer complications-balancing gastrointestinal and cardiovascular risks. Nature Clin. Practice Gastroenterol. Hepatol. 3 (2006) 563-573
9. Chatterjee A., and Pakrashi S.C. Treatise of Indian Medicinal Plants vol. I (1995), CSIR Publication, New Delhi 26
10. 2 cytokine balance. Nitric Oxide 15 (2006) 408-416
11. Del Ara Rangel M., Gozalez-Polo R.A., Caro A., del-Amo E., Palomo L., Soler E.G.H., and Fuentes J.M. Diagnostic performance of arginase activity in colorectal cancer. Clin. Exp. Med. 2 (2002) 53-57
12. Dokmeci D., Akpolat M., Aydogu N., Doganay L., and Turan F.N. l-Carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacol. Rep. 57 (2005) 481-488
13. Fiorucci S., Antonelli E., and Morelli A. Mechanism of non-steroidal anti-inflammatory drug-gastropathy. Dig. Liv. Dis. 31 suppl 2 (2001) S35-S43
14. Goldstein J.L., Johanson J.F., Hawkey C.J., Suchower L.J., and Brown K.A. Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazole. Aliment Pharmacol Ther 26 (2007) 1101-1111
15. Graham D.Y., Smith J.L., Spjut H.J., and Torres E. Gastric adaptation. Studies in humans during continuous aspirin administration. Gastroenterol. 95 (1988) 327-333
16. Isenberg J.I., McQuaid K.R., Laine L., and Rubin W. Acid-peptic disorders. In: Yamada T., Alpers D.H., Owyng C., Powell D.W., and Silverstein F.E. (Eds). Textbook of Gastroenterology vol. 1 (1991), Lippincott, Philadelphia 1253
17. Jaiswal M., LaRusso N.F., and Gores G.J. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 281 (2001) G626-G634
18. Jenkinson C.P., Grody W.W., and Cederbaum S.D. Comparative properties of arginases. Comp. Biochem. Physiol. 114B (1996) 107-132
19. Kaviratne M., Hesse M., Leusink M., Cheever A.W., Davies S.J., McKerrow J.H., Wakefield L.M., Letterio J.J., and Wynn T.A. IL-13 activates a mechanism of liver fibrosis that is completely TGF-β independent. J. Immunol. 173 (2004) 4020-4029
20. Konturek S.J., Brzozowski T., Majka J., Pytko-Polonczyk J., and Stachura J. Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur. J. Pharmacol. 239 (1993) 215-217
21. Luo J.C., Shin V.Y., Liu E.S.L., So W.H.L., Ye Y.N., Chang F.Y., and Cho C.H. Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats. J. Pharm. Exp. Thearp. 307 (2003) 692-698
22. Ma L., and Wallace J.L. Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 279 (2000) G341-346
23. McCarthy D.M. Nonsteroidal anti-inflammatory drug-induced ulcers: management by traditional therapies. Gastroenterol. 96 (1989) 662-674
24. Mckellar G., Madhok R., and Singh G. The problem with NSAIDs: what data to believe? Curr. Pain Headache Rep. 11 (2007) 423-427
25. Meurs H., Maarsingh H., and Zaagsma J. Response to Ricciardolo: the functional significance of arginase in asthma is supported by gene expression. Trends Pharmacol. Sci. 11 (2003) 562-563
26. Mitani T., Terashima M., Yoshimura H., Nariai Y., and Tanigawa Y. TGF-β1 enhances degradation of IFN-γ induced iNOS protein via proteasomes in RAW 264.7 cells. Nitric Oxide 13 (2005) 78-87
27. 2 cytokines. Eur. J. Immunol. 25 (1995) 1101-1104
28. Murphy M.P. Nitric oxide and cell death. Biochim. Biophys. Acta 1411 (1999) 401-414
29. Ng K.M., Cho C.H., Chang F.Y., Luo J.C., Lin H.C., Lin H.Y., Chi C.W., and Lee S.D. Omeprazole promotes gastric epithelial cell migration. J. Pharm. Pharmacol. 60 (2008) 655-660
30. Ross J.A., Auger M.J., Burke B., and Lewis C.E. The biology of the macrophage. In: Burke B., and Lewis C.E. (Eds). The Macrophage. 2nd ed. (2002), Oxford Medical Publ., Oxford, UK 1-72
31. Satriano J. Interregulation of nitric oxide and polyamines. Amino Acids 26 (2004) 321-329
32. Satriano J. Agmatine: at the crossroads of the arginine pathways. Ann. N.Y. Acad. Sci. 1009 (2003) 34-43
33. Shearer J.D., Richards J.R., Mills C.D., and Caldwell M.D. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am. J. Physiol. 272 (1997) E181
34. Slomiany B.L., Piotrowski J., and Slomiany A. Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: effect of antiulcer agents. Scand. J. Gastroenterol. 34 (1999) 459-464
35. Souza M.H.L.P., Lemos H.P., Oliveira R.B., and Cunha F.Q. Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice. Gut 53 (2004) 791-796
36. Tak P.P., and Firestein G.S. NF-κB: a key role in inflammatory diseases. J. Clin. Invest. 107 (2001) 7-11
37. Suzuki K., Ota H., Sasagawa S., Sakatani T., and Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal. Biochem. 132 (1983) 345-352
38. Takeuchi Y., Kitano S., Bandoh T., Matsumoto T., Baatar D., and Kai S. Acceleration of gastric ulcer healing by omeprazole in portal hypertensive rats. Is its action mediated by gastrin release and the stimulation of epithelial proliferation?. Eur. Surg. Res. 35 (2003) 75-80
39. Tarnawski A.S., and Jones M.K. Inhibition of angiogenesis by NSAIDs: molecular mechanism and clinical applications. J. Mol. Med. 81 (2003) 627-636
40. Tarnawski A., Szabo I.L., Husain S.S., and Soreghan B. Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J. Physio-Paris. 95 (2001) 337-344
41. Thakur V.S., Shankar B., Chatterjee S., Premachandran S., and Sainis K.B. Role of tumor derived transforming growth factor-beta 1 (TGF β1) in site-dependant tumorigenicity of murine ascitic lymphosarcoma. Cancer Immunol. Immunother. 54 (2005) 837-847
42. Warner T.D., Giuliano F., Vojnovic I., Bukasa A., Mitchell J.A., and Vane J.R. Nonsteroidal drug selectivities for cyclooxygenase-1 rather than cyclooxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc. Natl. Acad. Sci. USA. 96 (1999) 7563-7568
43. Whittle B.J.R. The physiology of the gastrointestinal tract. In: Johnson L.R. (Ed) (1994), Raven, New York 267-294
44. Wolfe M.M., Lichtenstein D.R., and Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. New. Engl. J. Med. 340 (1999) 1888-1899 Erratum N Engl J Med 340: 1888-1899
45. Yoshikawa T., Naito Y., Kishi A., Tomii T., Kaneko T., Iinuma S., Ichikawa H., Yasuda M., Takahashi S., and Kondo M. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 34 (1993) 732-737
46. Ziche M., Morbidelli L., Masini E., Amerini S., Granger H.J., and Maggi C.A. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94 (1994) 2036-2044