메뉴 건너뛰기




Volumn 50, Issue SUPPL. 1, 2005, Pages

Cellular and molecular mechanisms of gastrointestinal ulcer healing

Author keywords

Gene therapy; Granulation tissue; Growth factor; Re epithelialization; Signaling

Indexed keywords

ACTIN; ANGIOPOIETIN; ANGIOPOIETIN 1; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; ENDOTHELIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; KERATINOCYTE GROWTH FACTOR; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; RAC PROTEIN; RAS PROTEIN; RHO FACTOR; SCATTER FACTOR; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CELL GROWTH FACTOR 165; VASCULOTROPIN;

EID: 25644437787     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2803-6     Document Type: Review
Times cited : (344)

References (54)
  • 2
    • 0000173513 scopus 로고
    • Cellular mechanisms of gastric ulcer healing
    • W Domschke, SJ Konturek (eds). Berlin New York, Springer
    • Tarnawski A: Cellular mechanisms of gastric ulcer healing. In The Stomach. W Domschke, SJ Konturek (eds). Berlin New York, Springer, 1993, pp 177-192
    • (1993) The Stomach , pp. 177-192
    • Tarnawski, A.1
  • 3
    • 0012685313 scopus 로고    scopus 로고
    • Molecular mechanism of ulcer healing
    • Tarnawski A: Molecular mechanism of ulcer healing. Drug News Perspect 13:158-168, 2000
    • (2000) Drug News Perspect , vol.13 , pp. 158-168
    • Tarnawski, A.1
  • 4
    • 0024993310 scopus 로고
    • Vascular and microvascular changes - Key factors in the development of acetic acid-induced gastric ulcers in rats
    • Tarnawski A, Hollander D, Stachura J, et al.: Vascular and microvascular changes - key factors in the development of acetic acid-induced gastric ulcers in rats. J Clin Gastroenterol 12(1):S148-S157, 1990
    • (1990) J Clin Gastroenterol , vol.12 , Issue.1
    • Tarnawski, A.1    Hollander, D.2    Stachura, J.3
  • 5
    • 0036163642 scopus 로고    scopus 로고
    • Esophageal ulceration activates genes encoding keratinocyte growth factor and its receptor in rats: A key to esophageal ulcer healing?
    • Baatar D, Kawanaka H, Szabo IL, Pai R, Jones MK, Kitano S, Tarnawski AS: Esophageal ulceration activates genes encoding keratinocyte growth factor and its receptor in rats: a key to esophageal ulcer healing? Gastroenterology 122:458-468, 2002
    • (2002) Gastroenterology , vol.122 , pp. 458-468
    • Baatar, D.1    Kawanaka, H.2    Szabo, I.L.3    Pai, R.4    Jones, M.K.5    Kitano, S.6    Tarnawski, A.S.7
  • 9
    • 0035751805 scopus 로고    scopus 로고
    • Surgical biology of wound healing
    • Vanwijck R: Surgical biology of wound healing. Bull Mem Acad R Med Belg 56(3-4):175-184, 2001
    • (2001) Bull Mem Acad R Med Belg , vol.56 , Issue.3-4 , pp. 175-184
    • Vanwijck, R.1
  • 10
    • 0033134603 scopus 로고
    • The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor-and MAP kinase-dependent interregulation
    • Taupin D, Wu D-C, Jeon W-K, Devaney K, Wang TC, Podolsky DK: The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor-and MAP kinase-dependent interregulation. J Clin Invest 103:R31-R38, 1990
    • (1990) J Clin Invest , vol.103
    • Taupin, D.1    Wu, D.-C.2    Jeon, W.-K.3    Devaney, K.4    Wang, T.C.5    Podolsky, D.K.6
  • 11
    • 0034030123 scopus 로고    scopus 로고
    • Peptide gene expression in gastrointestinal mucosal ulceration: Ordered sequence or redundancy?
    • Wong WM, Playford RJ, Wright NA: Peptide gene expression in gastrointestinal mucosal ulceration: ordered sequence or redundancy? Gut 46:286-292, 2000
    • (2000) Gut , vol.46 , pp. 286-292
    • Wong, W.M.1    Playford, R.J.2    Wright, N.A.3
  • 12
    • 0026520710 scopus 로고
    • Increased expression of epidermal growth factor receptor during gastric ulcer healing rats
    • Tarnawski A, Stachura J, Durbin T, Sarfeh IJ, Gergely H: Increased expression of epidermal growth factor receptor during gastric ulcer healing rats. Gastroenterology 102:695-698, 1992
    • (1992) Gastroenterology , vol.102 , pp. 695-698
    • Tarnawski, A.1    Stachura, J.2    Durbin, T.3    Sarfeh, I.J.4    Gergely, H.5
  • 13
    • 0025139164 scopus 로고
    • Induction of a novel epidermal growth factor-secreting cell lineage mucosal ulceration in human gastrointestinal stem cells
    • Wright NA, Pike C, Elia G: Induction of a novel epidermal growth factor-secreting cell lineage mucosal ulceration in human gastrointestinal stem cells. Nature 343:82-85, 1990
    • (1990) Nature , vol.343 , pp. 82-85
    • Wright, N.A.1    Pike, C.2    Elia, G.3
  • 14
    • 0032429008 scopus 로고    scopus 로고
    • The role of EGF and its receptor in mucosal protection, adaptation to injury and ulcer healing. Involvement of EGF-R signal transduction pathways
    • Tarnawski A, Jones K: The role of EGF and its receptor in mucosal protection, adaptation to injury and ulcer healing. Involvement of EGF-R signal transduction pathways. J Clin Gastroenterol 27:S12-S20, 1998
    • (1998) J Clin Gastroenterol , vol.27
    • Tarnawski, A.1    Jones, K.2
  • 16
    • 2942616971 scopus 로고    scopus 로고
    • Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing
    • Chai J, Baatar D, Tarnawski AS: Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Gastroenterology 126:1809-1818, 2004
    • (2004) Gastroenterology , vol.126 , pp. 1809-1818
    • Chai, J.1    Baatar, D.2    Tarnawski, A.S.3
  • 17
    • 0027299745 scopus 로고
    • On the crawling of animal cells
    • Stossel TP: On the crawling of animal cells. Science 260:1986-1994, 1993
    • (1993) Science , vol.260 , pp. 1986-1994
    • Stossel, T.P.1
  • 18
    • 0010286952 scopus 로고
    • Vienna New York, Springer
    • Schliwa M: The cytoskeleton. Vienna New York, Springer, 1986, p 326
    • (1986) The Cytoskeleton , pp. 326
    • Schliwa, M.1
  • 19
    • 0031936080 scopus 로고    scopus 로고
    • Epithelial growth factor receptor stimulated intestinal epithelial cell migration requirements phospholipase C activity
    • Polk DB: Epithelial growth factor receptor stimulated intestinal epithelial cell migration requirements phospholipase C activity. Gastroenterology 114:493-502, 1998
    • (1998) Gastroenterology , vol.114 , pp. 493-502
    • Polk, D.B.1
  • 20
    • 0029551217 scopus 로고
    • Platelet derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation
    • Bornfeldt KE, Rainses EW, Graves EM, Skinne MP, Krebs EG, Ross R: Platelet derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Ann NY Acad Sci 766:416-430, 1995
    • (1995) Ann NY Acad Sci , vol.766 , pp. 416-430
    • Bornfeldt, K.E.1    Rainses, E.W.2    Graves, E.M.3    Skinne, M.P.4    Krebs, E.G.5    Ross, R.6
  • 21
    • 0031898865 scopus 로고    scopus 로고
    • Induction of mitogen activated protein kinase signal transduction pathway during gastric ulcer healing in rat model
    • Pai R, Ohta M, Itani RM, Sarfeh IJ, Tarnawski AS: Induction of mitogen activated protein kinase signal transduction pathway during gastric ulcer healing in rat model. Gastroenterology 114:706-713, 1998
    • (1998) Gastroenterology , vol.114 , pp. 706-713
    • Pai, R.1    Ohta, M.2    Itani, R.M.3    Sarfeh, I.J.4    Tarnawski, A.S.5
  • 22
    • 0032441626 scopus 로고    scopus 로고
    • Translocation of MAP (ERK-1 and -2) kinases to cell nuclei and activation of c-fos gene during healing of experimental gastric ulcer
    • Tarnawski A, Pai R: Translocation of MAP (ERK-1 and -2) kinases to cell nuclei and activation of c-fos gene during healing of experimental gastric ulcer. J Physiol Pharmacol 49:479-187, 1998
    • (1998) J Physiol Pharmacol , vol.49 , pp. 479-1187
    • Tarnawski, A.1    Pai, R.2
  • 23
    • 0032707440 scopus 로고    scopus 로고
    • Activation of Raf-1 during experimental gastric ulcer healing is ras-mediated and protein kinase C-independent
    • Pai R, Jones MK, Tomikawa M, Tarnawski AS: Activation of Raf-1 during experimental gastric ulcer healing is ras-mediated and protein kinase C-independent. Am J Pathol 155:1759-1766, 1999
    • (1999) Am J Pathol , vol.155 , pp. 1759-1766
    • Pai, R.1    Jones, M.K.2    Tomikawa, M.3    Tarnawski, A.S.4
  • 24
    • 0000485644 scopus 로고
    • Role of angiogenesis in healing of experimental gastric ulcer
    • F Halter, A Garner, GNJ Tytgat (eds). Dordrecht/Boston/Eondon, Kluwer
    • Tarnawski A, Hollander D, Stachura J, Gergely H, Krause WJ, Sarfeh IJ: Role of angiogenesis in healing of experimental gastric ulcer. In Mechanisms of Peptic Ulcer Healing. F Halter, A Garner, GNJ Tytgat (eds). Dordrecht/Boston/ Eondon, Kluwer, 1991, pp 165-171
    • (1991) Mechanisms of Peptic Ulcer Healing , pp. 165-171
    • Tarnawski, A.1    Hollander, D.2    Stachura, J.3    Gergely, H.4    Krause, W.J.5    Sarfeh, I.J.6
  • 25
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W: Mechanisms of angiogenesis. Nature 386:671-73, 1997
    • (1997) Nature , vol.386 , pp. 671-673
    • Risau, W.1
  • 26
    • 0030448814 scopus 로고    scopus 로고
    • Blood vessel formation: What is its molecular basis?
    • Folkman J, D'Amore PA: Blood vessel formation: what is its molecular basis? Cell 87:1153-1155, 1996
    • (1996) Cell , vol.87 , pp. 1153-1155
    • Folkman, J.1    D'Amore, P.A.2
  • 27
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N: Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25:581-611, 2004
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 28
    • 9444243244 scopus 로고    scopus 로고
    • Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis: Insight into the mechanisms
    • Chai J, Baatar D, Tarnawski AS: Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis: insight into the mechanisms. FASEB J 18:1264-1266, 2004
    • (2004) FASEB J , vol.18 , pp. 1264-1266
    • Chai, J.1    Baatar, D.2    Tarnawski, A.S.3
  • 29
    • 0026070033 scopus 로고
    • Duodenal ulcer. Discovery of a new mechanisms and development of angiogenic therapy that accelerates healing
    • Folkman J, Szabo S, Stovroff M, McNeil P, Li W, Shing Y: Duodenal ulcer. Discovery of a new mechanisms and development of angiogenic therapy that accelerates healing. Ann Surg 214:414-127, 1991
    • (1991) Ann Surg , vol.214 , pp. 414-1127
    • Folkman, J.1    Szabo, S.2    Stovroff, M.3    McNeil, P.4    Li, W.5    Shing, Y.6
  • 30
    • 0028270417 scopus 로고
    • Accelerated healing of duodenal ulcers by oral administration of basic fibroblast growth factors in rats
    • Szabo S, Folkman J, Vattay P, et al.: Accelerated healing of duodenal ulcers by oral administration of basic fibroblast growth factors in rats. Gastroenterology 106:1106-1111, 1994
    • (1994) Gastroenterology , vol.106 , pp. 1106-1111
    • Szabo, S.1    Folkman, J.2    Vattay, P.3
  • 31
    • 0002241192 scopus 로고    scopus 로고
    • Modulation of vascular factors by VEGF/VPF is sufficient for chronic ulcer healing and acute gastroprotection
    • Szabo S, Folkman J, Vincze A, Sandor ZS, Gombos A: Modulation of vascular factors by VEGF/VPF is sufficient for chronic ulcer healing and acute gastroprotection. Gastroenterology 122:A303, 1997
    • (1997) Gastroenterology , vol.122
    • Szabo, S.1    Folkman, J.2    Vincze, A.3    Sandor, Z.S.4    Gombos, A.5
  • 32
  • 33
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by NSAIDs. Insight into the mechanisms and implications for cancer growth and ulcer healing
    • Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS: Inhibition of angiogenesis by NSAIDs. Insight into the mechanisms and implications for cancer growth and ulcer healing. Nature Med 5:1418-1423, 1999
    • (1999) Nature Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3    Levin, E.4    Itani, R.M.5    Sarfeh, I.J.6    Tarnawski, A.S.7
  • 34
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • Davis S, Aldrich TH, Jones PF, et al.: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87:1161-1169, 1996
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3
  • 35
    • 0030480322 scopus 로고    scopus 로고
    • Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    • Suri C, Jones PF, Patan S, et al.: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87:1171-1180, 1996
    • (1996) Cell , vol.87 , pp. 1171-1180
    • Suri, C.1    Jones, P.F.2    Patan, S.3
  • 36
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre PC, Suri C, Jones PF, et al.: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277:55-60, 1997
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 37
    • 0033570185 scopus 로고    scopus 로고
    • Angiopoietin-1 and -2 coiled coil domains mediate distinct oligomerization patterns, but fibrinogen-like domains mediate ligand activity
    • Procopio WN, Pelavin PI, Lee WMF, Yeildong NM: Angiopoietin-1 and -2 coiled coil domains mediate distinct oligomerization patterns, but fibrinogen-like domains mediate ligand activity. J Biol Chem 274:30196-30201, 1999
    • (1999) J Biol Chem , vol.274 , pp. 30196-30201
    • Procopio, W.N.1    Pelavin, P.I.2    Lee, W.M.F.3    Yeildong, N.M.4
  • 38
    • 0032985888 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
    • Oh H, Takagi H, Suzuma K, Otani A, et al.: Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 274:15723-15739, 1997
    • (1997) J Biol Chem , vol.274 , pp. 15723-15739
    • Oh, H.1    Takagi, H.2    Suzuma, K.3    Otani, A.4
  • 39
    • 0001598311 scopus 로고    scopus 로고
    • Gastric ulceration triggers activation of angiopoietin-1, -2 and Tie2 important for angiogenesis
    • Tarnawski A, Pai R, Jones MK, Szabo I, Sarfeh IJ: Gastric ulceration triggers activation of angiopoietin-1, -2 and Tie2 important for angiogenesis. Gastroenterology 118:A242, 2000
    • (2000) Gastroenterology , vol.118
    • Tarnawski, A.1    Pai, R.2    Jones, M.K.3    Szabo, I.4    Sarfeh, I.J.5
  • 41
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt AB, Dixit V, Ferrara N: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 13;273(46):30336-30343, 1998
    • (1998) J Biol Chem 13 , vol.273 , Issue.46 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, A.B.5    Dixit, V.6    Ferrara, N.7
  • 43
    • 0035834278 scopus 로고    scopus 로고
    • In vitro evidence for matrix regulation of intestinal epithelial biology during mucosal healing
    • Basson MD: In vitro evidence for matrix regulation of intestinal epithelial biology during mucosal healing. Life Sci 69:3005-3018, 2001
    • (2001) Life Sci , vol.69 , pp. 3005-3018
    • Basson, M.D.1
  • 45
    • 5644290622 scopus 로고    scopus 로고
    • Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing
    • Calabro A, Grappone C, Pellegrini G, Evangelista S, Tramontana M, Schuppan D, Herbst H, Milani S: Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Digestion 70:127-138, 2004
    • (2004) Digestion , vol.70 , pp. 127-138
    • Calabro, A.1    Grappone, C.2    Pellegrini, G.3    Evangelista, S.4    Tramontana, M.5    Schuppan, D.6    Herbst, H.7    Milani, S.8
  • 46
    • 0031778021 scopus 로고    scopus 로고
    • H. pylori culture supernatant interferes with EGF-activated signal transduction in human gastric Kato III cells
    • Pai R, Wyle FA, Cover TL, Itani RM, Tarnawski A: H. pylori culture supernatant interferes with EGF-activated signal transduction in human gastric Kato III cells. Am J Pathol 152:1617-1624, 1998
    • (1998) Am J Pathol , vol.152 , pp. 1617-1624
    • Pai, R.1    Wyle, F.A.2    Cover, T.L.3    Itani, R.M.4    Tarnawski, A.5
  • 47
    • 0242351598 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by NSAIDs: Molecular mechanisms and clinical implications
    • Tarnawski AS, Jones MK: Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. J Mol Med 81:627-636, 2003
    • (2003) J Mol Med , vol.81 , pp. 627-636
    • Tarnawski, A.S.1    Jones, M.K.2
  • 49
    • 0031667425 scopus 로고    scopus 로고
    • Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa. the key mechanisms for its ulcer healing action?
    • Tarnawski A, Arakawa Kobayashi TK: Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa. The key mechanisms for its ulcer healing action? Dig Dis Sci 43(9):90S-98S, 1998
    • (1998) Dig Dis Sci , vol.43 , Issue.9
    • Tarnawski, A.1    Arakawa Kobayashi, T.K.2
  • 52
    • 0036790429 scopus 로고    scopus 로고
    • Esophageal ulceration triggers expression of hypoxia-inducible factor-1α and activates vascular endothelial growth factor gene
    • Baatar D, Jones MK, Tsugawa K, Koh Gy, Kim I, Kitano S, Tarnawski AS: Esophageal ulceration triggers expression of hypoxia-inducible factor-1α and activates vascular endothelial growth factor gene. Am J Pathol 161:1449-1457, 2002
    • (2002) Am J Pathol , vol.161 , pp. 1449-1457
    • Baatar, D.1    Jones, M.K.2    Tsugawa, K.3    Koh, Gy.4    Kim, I.5    Kitano, S.6    Tarnawski, A.S.7
  • 54
    • 10044253117 scopus 로고    scopus 로고
    • Gene therapy with adenoviral plasmids or naked DNA of VEGF PDGF accelerates healing of duodenal ulcer in rats
    • Deng X, Szabo S, Khomenko T, Jadus MR, Yoshida M: Gene therapy with adenoviral plasmids or naked DNA of VEGF PDGF accelerates healing of duodenal ulcer in rats. J Pharmacol Exp Ther 311:982-988, 2004
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 982-988
    • Deng, X.1    Szabo, S.2    Khomenko, T.3    Jadus, M.R.4    Yoshida, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.