Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats

Clinical and Experimental Immunology

Volumn 143, Issue 1, 2006, Pages 24-29

  Mitsuyama, K ^a   Tsuruta, O ^a   Matsui, Y ^a   Harada, K ^a   Tomiyasu, N ^a   Suzuki, A ^a   Takaki, K ^a   Masuda, J ^a   Handa, K ^a   Satoh, Y ^b   Bennett, B L ^b   Toyonaga, A ^a   Sata, M ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CELGENE CORPORATION   (United States)

Author keywords

c Jun N terminal kinase (JNK); Experimentally induced gastric lesions; Rats

Indexed keywords

ALCOHOL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FEMALE; IMMUNOHISTOCHEMISTRY; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STOMACH INJURY; STOMACH MUCOSA LESION; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; GASTRITIS; METHODOLOGY; PATHOLOGY; SPRAGUE DAWLEY RAT; STOMACH MUCOSA; TIME;

ANIMALS; ANTHRACENES; BLOTTING, WESTERN; ENZYME ACTIVATION; ENZYME INHIBITORS; ETHANOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GASTRIC MUCOSA; GASTRITIS; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 33644833310     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02959.x     Document Type: Article

References (30)

1. Robinson MJ Cobb MH Mitogen-activated protein kinase pathways Curr Opin Cell Biol 1997 9 180 5
2. Seger R Krebs EG The MAPK signaling cascade FASEB J 1995 9 726 35
3. Derijard B Hibi M Wu I-H Barrett T Su B Deng T Karin M Davis RJ JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 1994 76 1025 37
4. Kallunki T Su B Tsigelny I Sluss H Derijard B Moore G Davis R Karin M JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation Genes Dev 1994 8 2996 3007
5. Jain J Valge-Archer VE Rao A Analysis of the AP-1 sites in the IL-2 promoter J Immunol 1992 148 1240 50
6. Foletta VC Segal DH Cohen DR Transcriptional regulation in the immune system: all roads lead to AP-1 J Leukocyte Biol 1998 63 139 52
7. Finkenzeller G Technau A Marme D Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor Biochem Biophys Res Commun 1995 208 432 9
8. Schanke JT Marcuzzi A Podzorski RP Van Ness B An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression Nucl Acids Res 1994 22 5425 32
9. von Knethen A Callsen D Brune B NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages Mol Biol Cell 1999 10 361 72
10. Pendas AM Balbin M Llano E Jimenez MG Lopez-Otin C Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13) Genomics 1997 40 222 33
11. Bennett BL Sasaki DT Murray BW et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase Proc Natl Acad Sci USA 2001 98 13681 6
12. Han Z Boyle DL Chang L Bennett B Karin M Yang L Manning AM Firestein GS c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis J Clin Invest 2001 108 73 81
13. Eynott PR Nath P Leung SY Adcock IM Bennett BL Chung KF Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase Br J Pharmacol 2003 140 1373 80. Epub: 17 November 2003.
14. Tarnawski A Hollander D Stachura J Krause WJ Gergely H Protective effect of sucralfate against alcohol-induced gastric mucosal injury in the rat. Macroscopic, histologic, ultrastructural, and functional time sequence analysis Gastroenterology 1985 88 334 52
15. Szabo S Mechanisms of mucosal injury in the stomach and duodenum. time-sequence analysis of morphologic, functional, biochemical and histochemical studies Scand J Gastroenterol 1987 127 21 8
16. Piotrowski J Piotrowski E Skrodzka D Slomiany A Slomiany BL Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents Biochem Mol Biol Int 1997 42 247 54
17. Jones MK Itani RM Wang H Tomikawa M Sarfeh IJ Szabo S Tarnawski AS Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury Am J Physiol 1999 276 G1345 55
18. Liu ES Cho CH Relationship between ethanol-induced gastritis and gastric ulcer formation in rats Digestion 2000 62 232 9
19. Szabo IL Kawanaka H Jones MK Pai R Soreghan BA Baatar D Husain SS Tarnawski AS Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: a trigger for angiogenesis? Life Sci 2001 69 3035 44
20. Matsui Y Mitsuyama K Tomiyasu N Toyonaga A Sata M Efficacy of vascular endothelial growth factor in the treatment of experimental gastric injury Digestion 2002 66 99 105
21. Pai R Ohta M Itani RM Sarfeh IJ Tarnawski AS Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats Gastroenterology 1998 114 706 13
22. Szabo S Trier JS Brown A Schnoor J Homan HD Bradford JC A quantitative method for assessing the extent of experimental gastric erosions and ulcers J Pharmacol Meth 1985 13 59 66
23. Takahashi S Keto Y Fujita T Uchiyama T Yamamoto A FR167653, a p38 mitogen-activated protein kinase inhibitor, prevents Helicobacter pylori-induced gastritis in Mongolian gerbils J Pharmacol Exp Ther 2001 296 48 56
24. Kobayashi N Kataoka T Ono A Tsukimi Y Okabe S Role of p38 mitogen-activated protein kinase in the healing of gastric ulcers in rats J Physiol Pharmacol 2001 52 195 210
25. Beales IL Calam J Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori, IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C Cytokine 1997 9 514 20
26. Kraft M Riedel S Maaser C Kucharzik T Steinbuechel A Domschke W Luegering N IFN-gamma synergizes with TNF-alpha but not with viable H. pylori in up-regulating CXC chemokine secretion in gastric epithelial cells Clin Exp Immunol 2001 126 474 81
27. Hiraoka S Miyazaki Y Kitamura S Toyota M Kiyohara T Shinomura Y Mukaida N Matsuzawa Y Gastrin induces CXC chemokine expression in gastric epithelial cells through activation of NF-kappaB Am J Physiol Gastrointest Liver Physiol 2001 281 G735 42
28. Nakachi N Klein TW Friedman H Yamamoto Y Helicobacter pylori infection of human gastric epithelial cells induces IL-8 and TNFalpha, but not TGFbeta1 mRNA FEMS Immunol Med Microbiol 2000 29 23 6
29. Takahashi S Fujita T Yamamoto A Role of nuclear factor-kappaB in gastric ulcer healing in rats Am J Physiol Gastrointest Liver Physiol 2001 280 G1296 304
30. Tebbutt NC Giraud AS Inglese M et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice Nat Med 2002 8 1089 97