Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action

World Journal of Gastroenterology

Volumn 13, Issue 27, 2007, Pages 3705-3713

  Bhattacharya, S ^a   Banerjee, D ^a   Bauri, A K ^b   Chattopadhyay, S ^b   Bandyopadhyay, Sandip K ^a  

^a Dr BC Roy Post Graduate Institute of Basic Medical Sciences   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Allylpyrocatechol; Antioxidant; Histopathology; Indomethacin; Mucin; Piper betel; Stomach ulcer

Indexed keywords

ALLYLPYROCATECHOL; ANTIULCER AGENT; BETEL EXTRACT; CATALASE; CATECHOL DERIVATIVE; INDOMETACIN; MALONALDEHYDE; MISOPROSTOL; MUCIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; HISTOPATHOLOGY; MALE; NONHUMAN; PROTEIN DETERMINATION; RAT; SPRAGUE DAWLEY RAT; STOMACH PROTECTION; STOMACH ULCER; ULCER HEALING;

EID: 34547667387     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i27.3705     Document Type: Article

References (36)

1. Hawkins C, Hanks GW. The gastroduodenal toxicity of nonsteroidal anti-inflammatory drugs: a review of the literature. J Pain Symptom Manage 2000; 20: 140-151
2. Pace V. Use of nonsteroidal anti-inflammatory drugs in cancer. Palliat Med 1995; 9: 273-286
3. Coruzzi G, Menozzi A, Dobrilla G. Novel non-steroidal antiinflammatory drugs: what we have learned from animal studies. Curr Drug Targets Inflamm Allergy 2004; 3: 43-61
4. Garner A. Adaptation in the pharmaceutical industry, with particular reference to gastrointestinal drugs and diseases. Scand J Gastroenterol Suppl 1992; 193: 83-89
5. Dhikav V, Singh S, Pande S, Chawla A, Anand KS. Non-steroidal drug-induced gastrointestinal toxicity: Mechanisms and management. J Indian Clin Med 2003; 4: 315-322
6. Miederer SE. Will anti-ulcer drugs soon differ only in their side effects? Fortschr Med 1986; 104: 918-920
7. Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res 2000; 14: 581-591
8. Yesilada E, Gurbuz I. A compilation of the studies on the antiulcerogenic effects of medicinal plants. In: Recent Progress in Medicinal Plants, vol. II: Phytochemistry and pharmacology. Singh S, Singh VK, Govil JN, editors. Houston: SCI Tech Publishing LLC, 2003: 111-174
9. Chatterjee A, Pakrashi SC. Treatise of Indian Medicinal Plants. New Delhi: CSIR Publication, 1995: 26
10. Prabhu MS, Platel K, Saraswathi G, Srinivasan K. Effect of orally administered betel leaf (Piper betle Linn.) on digestive enzymes of pancreas and intestinal mucosa and on bile production in rats. Indian J Exp Biol 1995; 33: 752-756
11. Majumdar B, Ray Chaudhuri SG, Ray A, Bandyopadhyay SK. Effect of ethanol extract of Piper betle Linn leaf on healing of NSAID-induced experimental ulcer - a novel role of free radical scavenging action. Indian J Exp Biol 2003; 41: 311-315
12. Rathee JS, Patro BS, Mula S, Gamre S, Chattopadhyay S. Antioxidant activity of piper betel leaf extract and its constituents. J Agric Food Chem 2006; 54: 9046-9054
13. Szabo S, Trier JS, Brown A, Schnoor J, Homan HD, Bradford JC. A quantitative method for assessing the extent of experimental gastric erosions and ulcers. J Pharmacol Methods 1985; 13: 59-66
14. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186: 407-421
15. Palamanda JR, Kehrer JP. Inhibition of protein carbonyl formation and lipid peroxidation by glutathione in rat liver microsomes. Arch Biochem Biophys 1992; 293: 103-109
16. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956; 62: 315-323
17. Luck H. Catalase. In: Methods of Enzymatic Analysis. Bergmeyer HU, editor. New York: Verlag Chemical and Academic Press, 1963: 885-888
18. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049-6055
19. Corne SJ, Morrissey SM, Woods RJ. Proceedings: A method for the quantitative estimation of gastric barrier mucus. J Physiol 1974; 242: 116P-117P
20. Winzler RJ. Determination of serum glycoproteins. Methods Biochem Anal 1955; 2: 279-311
21. Chang FY, Chen TS, Lee SD, Doong ML, Wang PS. Misoprostol-inhibited rat gastric emptying is independent of gastric inhibitory polypeptide release. Pharmacology 1999; 58: 265-269
22. Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 2003; 278: 10993-11001
23. McAlindon ME, Muller AF, Filipowicz B, Hawkey CJ. Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers. Gut 1996; 38: 518-524
24. Santos FA, Rao VS. 1,8-cineol, a food flavoring agent, prevents ethanol-induced gastric injury in rats. Dig Dis Sci 2001; 46: 331-337
25. Bilici D, Suleyman H, Banoglu ZN, Kiziltunc A, Avci B, Ciftcioglu A, Bilici S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig Dis Sci 2002; 47: 856-861
26. Bhattacharya S, Subramanian M, Roychowdhury S, Bauri AK, Kamat JP, Chattopadhyay S, Bandyopadhyay SK. Radioprotective property of the ethanolic extract of Piper betel Leaf. J Radiat Res (Tokyo) 2005; 46: 165-171
27. Marotta F, Tajiri H, Safran P, Fesce E, Ideo G. Ethanol-related gastric mucosal damage: evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant. Digestion 1999; 60: 538-543
28. El-Missiry MA, E1-Sayed IH, Othman AI. Protection by metal complexes with SOD-mimetic activity against oxidative gastric injury induced by indomethacin and ethanol in rats. Ann Clin Biochem 2001; 38: 694-700
29. Szabo S, Hollander D. Pathways of gastrointestinal protection and repair: mechanisms of action of sucralfate. Am J Med 1989; 86: 23-31
30. Tabor CW, Tabor H. Polyamines. Annu Rev Biochem 1984; 53: 749-790
31. Wang JY, Hsieh JS, Huang TJ. Changes in rat gastric mucosal glycoproteins in portal hypertension. Eur Surg Res 1997; 29: 280-286
32. Rainsford KD. The effects of aspirin and other non-steroid anti-inflammatory/analgesic drugs on gastro-intestinal mucus glycoprotein biosynthesis in vivo: relationship to ulcerogenic actions. Biochem Pharmacol 1978; 27: 877-885
33. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y, Nishimura S, Yoshida N, Kondo M. Effects of oxygen radical scavengers on the quality of gastric ulcer healing in rats. J Clin Gastroenterol 1995; 21 Suppl 1: S82-S86
34. James AH. Gastric epithelium in the duodenum. Gut 1964; 5: 285-294
35. Chang CC, Pan S, Lien GS, Liao CH, Chen SH, Cheng YS. Deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer: a correlated study. World J Gastroenterol 2005; 11: 1802-1805
36. Alanko J, Riutta A, Holm P, Mucha I, Vapaatalo H, Metsa-Ketela T. Modulation of arachidonic acid metabolism by phenols: relation to their structure and antioxidant/prooxidant. properties. Free Radic Biol Med 1999; 26: 193-201