A death-promoting role for ISG54/IFIT2

Journal of Interferon and Cytokine Research

Volumn 33, Issue 4, 2013, Pages 199-205

  Reich, Nancy C ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON STIMULATED GENE 54; NUCLEIC ACID BINDING PROTEIN; PROTEIN BCL 2; RNA BINDING PROTEIN; TETRATRICOPEPTIDE REPEAT 2; TETRATRICOPEPTIDE REPEAT PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; APOPTOSIS; CANCER INHIBITION; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EPITHELIAL MESENCHYMAL TRANSITION; GENE CONTROL; GENE DISRUPTION; GENE SEQUENCE; GENE STRUCTURE; HUMAN; INTRACELLULAR SIGNALING; MICROBIAL COLONIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; RNA BINDING; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION; HUMANS; INTERFERONS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; VIRUS DISEASES;

EID: 84876140441     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0159     Document Type: Review

References (67)

1. Adams JM, Cory S. 2007. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19:488-496.
2. Andersen J, VanScoy S, Cheng TF, Gomez D, Reich NC. 2008. IRF-3-dependent and augmented target genes during viral infection. Genes Immun 9:168-175.
3. Barber GN. 2011. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol 23:10-20.
4. Benedict CA, Norris PS, Ware CF. 2002. To kill or be killed: viral evasion of apoptosis. Nat Immunol 3:1013-1018.
5. Berchtold S, Manncke B, Klenk J, Geisel J, Autenrieth IB, Bohn E. 2008. Forced IFIT-2 expression represses LPS induced TNFalpha expression at posttranscriptional levels. BMC Immunol 9:75.
6. Best SM. 2008. Viral subversion of apoptotic enzymes: escape from death row. Annu Rev Microbiol 62:171-192.
7. Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, et al. 2007. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:799-816.
8. Blatch GL, Lassle M. 1999. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays 21:932-939.
9. Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR, Stark GR. 2007. Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 6:975-990.
10. Chawla-Sarkar M, Lindner DJ, Liu YF, Williams BR, Sen GC, Silverman RH, Borden EC. 2003. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8:237-249.
11. Clemens MJ. 2003. Interferons and apoptosis. J Interferon Cytokine Res 23:277-292.
12. D'Andrea LD, Regan L. 2003. TPR proteins: the versatile helix. Trends Biochem Sci 28:655-662.
13. Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, et al. 2010. 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 468:452-456.
14. Daly C, Reich NC. 1993. Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element. Mol Cell Biol 13:3756-3764.
15. Daly C, Reich NC. 1995. Characterization of specific DNAbinding factors activated by double-stranded RNA as positive regulators of interferon alpha/beta-stimulated genes. J Biol Chem 270:23739-23746.
16. de Veer MJ, Holko M, Frevel M, Walker E, Der S, Paranjape JM, Silverman RH, Williams BR. 2001. Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 69:912-920.
17. de Weerd NA, Nguyen T. 2012. The interferons and their receptors- distribution and regulation. Immunol Cell Biol 90:483-491.
18. Decker T, Lew DJ, Mirkovitch J, Darnell JE, Jr. 1991. Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. EMBO J 10:927-932.
19. Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, et al. 2012. Landscape of transcription in human cells. Nature 489: 101-108.
20. Earnshaw WC, Martins LM, Kaufmann SH. 1999. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68:383-424.
21. Fensterl V, Sen GC. 2011. The ISG56/IFIT1 gene family. J Interferon Cytokine Res 31:71-78.
22. Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, Diamond MS, Virgin HW, Sen GC. 2012. Interferon- Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis. PLoS Pathog 8:e1002712.
23. Fu XY, Kessler DS, Veals SA, Levy DE, Darnell JE, Jr. 1990. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci U S A 87:8555-8559.
24. Galluzzi L, Brenner C, Morselli E, Touat Z, Kroemer G. 2008. Viral control of mitochondrial apoptosis. PLoS Pathog 4:e1000018.
25. Gomez D, Reich NC. 2003. Stimulation of primary human endothelial cell proliferation by IFN. J Immunol 170:5373-5381.
26. Heylbroeck C, Balachandran S, Servant MJ, DeLuca C, Barber GN, Lin R, Hiscott J. 2000. The IRF-3 transcription factor mediates Sendai virus-induced apoptosis. J Virol 74:3781- 3792.
27. Hiscott J. 2007. Triggering the innate antiviral response through IRF-3 activation. J Biol Chem 282:15325-15329.
28. Iorio MV, Croce CM. 2012. microRNA involvement in human cancer. Carcinogenesis 33:1126-1133.
29. Jagus R, Joshi B, Barber GN. 1999. PKR, apoptosis and cancer. Int J Biochem Cell Biol 31:123-138.
30. Lai KC, Liu CJ, Chang KW, Lee TC. 2012. Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells. Oncogene [Epub ahead of print]; DOI: 10.1038/onc.2012. 384.
31. Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE, Jr. 1986. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proc Natl Acad Sci U S A 83:8929-8933.
32. Levy D, Reich N, Kessler D, Pine R, Darnell JE, Jr. 1988. Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it. Cold Spring Harb Symp Quant Biol 53 Pt 2:799-802.
33. Levy DE, Darnell JE, Jr. 2002. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3:651-662.
34. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB. 2009. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc Natl Acad Sci U S A 106:7945-7950.
35. Liu XY, Chen W, Wei B, Shan YF, Wang C. 2011. IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J Immunol 187:2559-2568.
36. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. 2011. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 44:517-531.
37. Lujambio A, Lowe SW. 2012. The microcosmos of cancer. Nature 482:347-355.
38. Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC. 1997. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J Biol Chem 272:20070-20076.
39. Ozato K, Tailor P, Kubota T. 2007. The interferon regulatory factor family in host defense: mechanism of action. J Biol Chem 282:20065-20069.
40. Perwitasari O, Cho H, Diamond MS, Gale M, Jr. 2011. Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. J Biol Chem 286:44412-44423.
41. Pichlmair A, Lassnig C, Eberle CA, Gorna MW, Baumann CL, Burkard TR, Burckstummer T, Stefanovic A, Krieger S, Bennett KL, et al. 2011. IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA. Nat Immunol 12:624-630.
42. Platanias LC. 2005. Mechanisms of type-I- and type-II-interferonmediated signalling. Nat Rev Immunol 5:375-386.
43. Saikia P, Fensterl V, Sen GC. 2010. The inhibitory action of P56 on select functions of E1 mediates interferon's effect on human papillomavirus DNA replication. J Virol 84:13036-13039.
44. Schindler C, Levy DE, Decker T. 2007. JAK-STAT signaling: from interferons to cytokines. J Biol Chem 282:20059-20063.
45. Schmeisser H, Mejido J, Balinsky CA, Morrow AN, Clark CR, Zhao T, Zoon KC. 2010. Identification of alpha interferoninduced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. J Virol 84:10671-10680.
46. Stark GR, Darnell JE, Jr. 2012. The JAK-STAT pathway at twenty. Immunity 36:503-514.
47. Stawowczyk M, Van Scoy S, Kumar KP, Reich NC. 2011. The interferon stimulated gene 54 promotes apoptosis. J Biol Chem 286:7257-7266.
48. Strasser A, O'Connor L, Dixit VM. 2000. Apoptosis signaling. Annu Rev Biochem 69:217-245.
49. Szretter KJ, Daniels BP, Cho H, Gainey MD, Yokoyama WM, Gale M, Jr., Virgin HW, Klein RS, Sen GC, Diamond MS. 2012. 2′-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. PLoS Pathog 8:e1002698.
50. Tamura T, Ishihara M, Lamphier MS, Tanaka N, Oishi I, Aizawa S, Matsuyama T, Mak TW, Taki S, Taniguchi T. 1995. An IRF- 1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376:596-599.
51. Terenzi F, Hui DJ, Merrick WC, Sen GC. 2006. Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. J Biol Chem 281:34064-34071.
52. Terenzi F, Pal S, Sen GC. 2005. Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54. Virology 340:116-124.
53. Terenzi F, Saikia P, Sen GC. 2008. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J 27:3311-3321.
54. Theofilopoulos AN, Kono DH, Beutler B, Baccala R. 2011. Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res 31:867-886.
55. Thyrell L, Erickson S, Zhivotovsky B, Pokrovskaja K, Sangfelt O, Castro J, Einhorn S, Grander D. 2002. Mechanisms of Interferon- alpha induced apoptosis in malignant cells. Oncogene 21:1251-1262.
56. Uematsu S, Akira S. 2007. Toll-like receptors and Type I interferons. J Biol Chem 282:15319-15323.
57. Wang C, Pflugheber J, Sumpter R, Jr., Sodora DL, Hui D, Sen GC, Gale M, Jr. 2003. Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication. J Virol 77:3898-3912.
58. Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP. 1998. PML is essential for multiple apoptotic pathways. Nat Genet 20:266-272.
59. Wathelet M, Moutschen S, Defilippi P, Cravador A, Collet M, Huez G, Content J. 1986. Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons. Eur J Biochem 155:11-17.
60. Weaver BK, Ando O, Kumar KP, Reich NC. 2001. Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53. FASEB J 15:501-515.
61. Weaver BK, Kumar KP, Reich NC. 1998. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol Cell Biol 18:1359-1368.
62. Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y. 2012. Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. Cell Res 22:1328-1338.
63. Yoneyama M, Fujita T. 2010. Recognition of viral nucleic acids in innate immunity. Rev Med Virol 20:4-22.
64. Yoneyama M, Suhara W, Fukuhara Y, Fukuda M, Nishida E, Fujita T. 1998. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J 17:1087-1095.
65. Youle RJ, Strasser A. 2008. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59.
66. Zhou A, Paranjape J, Brown TL, Nie H, Naik S, Dong B, Chang A, Trapp B, Fairchild R, Colmenares C, et al. 1997. Interferon action and apoptosis are defective in mice devoid of 2′,5′- oligoadenylate-dependent RNase L. EMBO J 16:6355-6363.
67. Zust R, Cervantes-Barragan L, Habjan M, Maier R, Neuman BW, Ziebuhr J, Szretter KJ, Baker SC, Barchet W, Diamond MS, et al. 2011. Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat Immunol 12:137-143.