Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53

FASEB Journal

Volumn 15, Issue 2, 2001, Pages 501-514

  Weaver, B K ^a   Ando, O ^a   Kumar, K P ^a   Reich, N C ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Defense; Gene expression; IRF 3; Transcription

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PARAMYXOVIRUS; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION;

APOPTOSIS; CELL NUCLEUS; CLONING, MOLECULAR; CREB-BINDING PROTEIN; DNA-BINDING PROTEINS; ETOPOSIDE; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERONS; LUMINESCENT PROTEINS; MUTAGENESIS, SITE-DIRECTED; NEWCASTLE DISEASE VIRUS; NUCLEAR PROTEINS; RNA, DOUBLE-STRANDED; RNA, VIRAL; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

PARAMYXOVIRIDAE; RNA VIRUSES;

EID: 0035128587     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0222com     Document Type: Article

References (62)

1. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
2. Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element
3. Characterization of specific DNA-binding factors activated by double-stranded RNA as positive regulators of interferon alpha/beta-stimulated genes
4. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
5. How cells respond to interferons
6. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
7. Signal transduction and activation of gene transcription by interferons
8. Signaling through the hematopoietic cytokine receptors
9. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
10. Regulation of gene expression by cytokines and virus in human cells lacking the type-I interferon locus
11. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
12. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
13. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
14. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
15. The growing family of interferon regulatory factors
16. The role of interferon regulatory factors in the interferon system and cell growth control
17. Interferon regulator factors: The next generation
18. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
19. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells
20. Caspases: Intracellular signaling by proteolysis
21. Caspases and caspase inhibitors
22. BCL-2 family members and the mitochondria in apoptosis
23. Complementation of a mutant cell line: Central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways
24. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses
25. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
26. Regulated nuclear/cytoplasmic localization of interferon regulatory factor-3, a subunit of the dsRNA activated transcription factor, DRAF1
27. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
28. Role of adenovirus E1B proteins in transformation: Altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein
29. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
30. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene
31. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element
32. Interferon-stimulated transcription: Isolation of an inducible gene and identification of its regulatory region
33. Viruses and apoptosis
34. Apoptosis as a cause of death in chicken embryos inoculated with Newcastle disease virus
35. Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32)
36. 125I-labeled human interferon to cell lines with low sensitivity to interferon
37. Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor IFNAR 2
38. PKR; a sentinel kinase for cellular stress
39. Cellular response to double-stranded RNA
40. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
41. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
42. Inhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection
43. The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein
44. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
45. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
46. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
47. Clinical applications of anticancer drugs targeted to topoisomerase II
48. Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: Etoposide inhibits the p53-Mdm2 autoregulatory feedback loop
49. Impact of RNase L overexpression on viral and cellular growth and death
50. p53, the cellular gatekeeper for growth and division
51. Regulation of the p53 rumor suppressor protein
52. The p53 pathway
53. Twenty years of p53 research: Structural and functional aspects of the p53 protein
54. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
55. Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding
56. Transcriptional repression by the C-terminal domain of p53
57. Type I interferons are essential mediators of apoptotic death in virally infected cells
58. Activation of interferon regulatory factor 3 in response to DNA damaging agents
59. The role of interferon regulatory factors in the interferon system and cell growth control
60. Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53
61. Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein