Inhibitor of κB kinase ε (IKKε), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection

Journal of Biological Chemistry

Volumn 286, Issue 52, 2011, Pages 44412-44423

  Perwitasari, Olivia ^a   Cho, Hyelim ^b   Diamond, Michael S ^b   Gale Jr , Michael ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ANALYSIS; DEPHOSPHORYLATIONS; IMMUNE DEFENSE; NUCLEAR-CYTOPLASMIC SHUTTLING; REGULATORY PATHWAY; SIGNALING PATHWAYS; VIRAL PATHOGENESIS; VIRUS DISSEMINATION; VIRUS INFECTION; WEST NILE VIRUS; WNV INFECTIONS;

AMINO ACIDS; ENZYMES; GENES; MAMMALS; PHOSPHORYLATION;

VIRUSES;

ALPHA INTERFERON RECEPTOR; BETA INTERFERON RECEPTOR; ENZYME INHIBITOR; I KAPPA B KINASE EPSILON; IFIT2 PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERFERON STIMULATED GENE FACTOR; NUCLEIC ACID BINDING PROTEIN; SERINE; STAT1 PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFECTION CONTROL; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; WEST NILE FEVER; WEST NILE FLAVIVIRUS; WILD TYPE;

ANIMALS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CRICETINAE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; STAT1 TRANSCRIPTION FACTOR; WEST NILE FEVER; WEST NILE VIRUS;

EID: 84455161741     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.285205     Document Type: Article

References (64)

1. Lanciotti, R. S., Roehrig, J. T., Deubel, V., Smith, J., Parker, M., Steele, K., Crise, B., Volpe, K. E., Crabtree, M. B., Scherret, J. H., Hall, R. A., MacKenzie, J. S., Cropp, C. B., Panigrahy, B., Ostlund, E., Schmitt, B., Malkinson, M., Banet, C., Weissman, J., Komar, N., Savage, H. M., Stone, W., McNamara, T., and Gubler, D. J. (1999) Science 286, 2333-2337
2. Smithburn, K. C., Hughes, T. P., Burke, A. W., and Paul, J. H. (1940) J. Trop. Med. Hyg. 20, 471-492
3. Berthet, F. X., Zeller, H. G., Drouet, M. T., Rauzier, J., Digoutte, J. P., and Deubel, V. (1997) J. Gen. Virol. 78, 2293-2297
4. Lanciotti, R. S., Ebel, G. D., Deubel, V., Kerst, A. J., Murri, S., Meyer, R., Bowen, M., McKinney, N., Morrill, W. E., Crabtree, M. B., Kramer, L. D., and Roehrig, J. T. (2002) Virology 298, 96-105
5. Lvov, D. K., Butenko, A. M., Gromashevsky, V. L., Kovtunov, A. I., Prilipov, A. G., Kinney, R., Aristova, V. A., Dzharkenov, A. F., Samokhvalov, E. I., Savage, H. M., Shchelkanov, M. Y., Galkina, I. V., Deryabin, P. G., Gubler, D. J., Kulikova, L. N., Alkhovsky, S. K., Moskvina, T. M., Zlobina, L. V., Sadykova, G. K., Shatalov, A. G., Lvov, D. N., Usachev, V. E., and Voronina, A. G. (2004) Arch. Virol. Suppl. 85-96
6. Jia, X. Y., Briese, T., Jordan, I., Rambaut, A., Chi, H. C., Mackenzie, J. S., Hall, R. A., Scherret, J., and Lipkin, W. I. (1999) Lancet 354, 1971-1972
7. Daffis, S., Samuel, M. A., Suthar, M. S., Keller, B. C., Gale, M., Jr., and Diamond, M. S. (2008) J. Virol. 82, 8465-8475
8. Keller, B. C., Fredericksen, B. L., Samuel, M. A., Mock, R. E., Mason, P. W., Diamond, M. S., and Gale, M., Jr. (2006) J. Virol. 80, 9424-9434
9. Keller, B. C., Johnson, C. L., Erickson, A. K., and Gale, M., Jr. (2007) Cytokine Growth Factor Rev. 18, 535-544
10. Fredericksen, B. L., Keller, B. C., Fornek, J., Katze, M. G., and Gale, M., Jr. (2008) J. Virol. 82, 609-616
11. Loo, Y. M., Fornek, J., Crochet, N., Bajwa, G., Perwitasari, O., Martinez- Sobrido, L., Akira, S., Gill, M. A., García-Sastre, A., Katze, M. G., and Gale, M., Jr. (2008) J. Virol. 82, 335-345
12. Suthar, M. S., Ma, D. Y., Thomas, S., Lund, J. M., Zhang, N., Daffis, S., Rudensky, A. Y., Bevan, M. J., Clark, E. A., Kaja, M. K., Diamond, M. S., and Gale, M., Jr. (2010) PLoS Pathog. 6, e1000757
13. Gale, M., Jr., and Foy, E. M. (2005) Nature 436, 939-945
14. Saito, T., and Gale, M., Jr. (2007) Curr. Opin. Immunol. 19, 17-23
15. Darnell, J. E., Jr., Kerr, I. M., and Stark, G. R. (1994) Science 264, 1415-1421
16. Hengel, H., Koszinowski, U. H., and Conzelmann, K. K. (2005) Trends Immunol. 26, 396-401
17. Levy, D. E., and García-Sastre, A. (2001) Cytokine Growth Factor Rev. 12, 143-156
18. Sen, G. C. (2001) Annu. Rev. Microbiol. 55, 255-281
19. Uddin, S., Sassano, A., Deb, D. K., Verma, A., Majchrzak, B., Rahman, A., Malik, A. B., Fish, E. N., and Platanias, L. C. (2002) J. Biol. Chem. 277, 14408-14416
20. Varinou, L., Ramsauer, K., Karaghiosoff, M., Kolbe, T., Pfeffer, K., Müller, M., and Decker, T. (2003) Immunity. 19, 793-802
21. Tenoever, B. R., Ng, S. L., Chua, M. A., McWhirter, S. M., García-Sastre, A., and Maniatis, T. (2007) Science 315, 1274-1278
22. Platanias, L. C. (2005) Nat. Rev. Immunol. 5, 375-386
23. Daffis, S., Szretter, K. J., Schriewer, J., Li, J., Youn, S., Errett, J., Lin, T. Y., Schneller, S., Zust, R., Dong, H., Thiel, V., Sen, G. C., Fensterl, V., Klimstra, W. B., Pierson, T. C., Buller, R. M., Gale, M., Jr., Shi, P. Y., and Diamond, M. S. (2010) Nature 468, 452-456
24. Fensterl, V., and Sen, G. C. (2011) J. Interferon Cytokine Res. 31, 71-78
25. Sarkar, S. N., and Sen, G. C. (2004) Pharmacol. Ther. 103, 245-259
26. Terenzi, F., Hui, D. J., Merrick, W. C., and Sen, G. C. (2006) J. Biol. Chem. 281, 34064-34071
27. Hui, D. J., Terenzi, F., Merrick, W. C., and Sen, G. C. (2005) J. Biol. Chem. 280, 3433-3440
28. Wang, C., Pflugheber, J., Sumpter, R., Jr., Sodora, D. L., Hui, D., Sen, G. C., and Gale, M., Jr. (2003) J. Virol. 77, 3898-3912
29. Daffis, S., Samuel, M. A., Keller, B. C., Gale, M., Jr., and Diamond, M. S. (2007) PLoS Pathog. 3, e106
30. Bluyssen, H. A., Vlietstra, R. J., Faber, P. W., Smit, E. M., Hagemeijer, A., and Trapman, J. (1994) Genomics 24, 137-148
31. Bandyopadhyay, S. K., Leonard, G. T., Jr., Bandyopadhyay, T., Stark, G. R., and Sen, G. C. (1995) J. Biol. Chem. 270, 19624-19629
32. Wacher, C., Müller, M., Hofer, M. J., Getts, D. R., Zabaras, R., Ousman, S. S., Terenzi, F., Sen, G. C., King, N. J., and Campbell, I. L. (2007) J. Virol. 81, 860-871
33. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., and Akira, S. (2004) J. Exp. Med. 199, 1641-1650
34. Foy, E., Li, K., Wang, C., Sumpter, R., Jr., Ikeda, M., Lemon, S. M., and Gale, M., Jr. (2003) Science 300, 1145-1148
35. Peters, R. T., Liao, S. M., and Maniatis, T. (2000) Mol. Cell 5, 513-522
36. Breiman, A., Grandvaux, N., Lin, R., Ottone, C., Akira, S., Yoneyama, M., Fujita, T., Hiscott, J., and Meurs, E. F. (2005) J. Virol. 79, 3969-3978
37. Xie, X., Zhang, D., Zhao, B., Lu, M. K., You, M., Condorelli, G., Wang, C. Y., and Guan, K. L. (2011) Proc. Nat. Acad. Sci. U.S.A. 108, 6474-6479
38. Pellegrini, S., John, J., Shearer, M., Kerr, I. M., and Stark, G. R. (1989) Mol. Cell. Biol. 9, 4605-4612
39. Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., and Taniguchi, T. (2000) Immunity. 13, 539-548
40. Haspel, R. L., Salditt-Georgieff, M., and Darnell, J. E., Jr. (1996) EMBO J. 15, 6262-6268
41. McBride, K. M., and Reich, N. C. (2003) Sci. STKE 2003, RE13
42. Mowen, K., and David, M. (2000) Mol. Cell. Biol. 20, 7273-7281
43. Jiang, D., Weidner, J. M., Qing, M., Pan, X. B., Guo, H., Xu, C., Zhang, X., Birk, A., Chang, J., Shi, P. Y., Block, T. M., and Guo, J. T. (2010) J. Virol. 84, 8332-8341
44. Zhang, Y., Burke, C. W., Ryman, K. D., and Klimstra, W. B. (2007) J. Virol. 81, 11246-11255
45. Terenzi, F., Saikia, P., and Sen, G. C. (2008) EMBO J. 27, 3311-3321
46. Daffis, S., Suthar, M. S., Gale, M., Jr., and Diamond, M. S. (2009) J. Innate Immun. 1, 435-445
47. Daffis, S., Lazear, H. M., Liu, W. J., Audsley, M., Engle, M., Khromykh, A. A., and Diamond, M. S. (2011) J. Virol. 85, 5664-5668
48. Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S. M., and Maniatis, T. (2003) Nat. Immunol. 4, 491-496
49. tenOever, B. R., Sharma, S., Zou, W., Sun, Q., Grandvaux, N., Julkunen, I., Hemmi, H., Yamamoto, M., Akira, S., Yeh, W. C., Lin, R., and Hiscott, J. (2004) J. Virol. 78, 10636-10649
50. McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., and Maniatis, T. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 233-238
51. Maher, S. G., Sheikh, F., Scarzello, A. J., Romero-Weaver, A. L., Baker, D. P., Donnelly, R. P., and Gamero, A. M. (2008) Cancer Biol. Ther. 7, 1109-1115
52. Wong, A. H., Tam, N. W., Yang, Y. L., Cuddihy, A. R., Li, S., Kirchhoff, S., Hauser, H., Decker, T., and Koromilas, A. E. (1997) EMBO J. 16, 1291-1304
53. Samuel, M. A., Whitby, K., Keller, B. C., Marri, A., Barchet, W., Williams, B. R., Silverman, R. H., Gale, M., Jr., and Diamond, M. S. (2006) J. Virol. 80, 7009-7019
54. Gilfoy, F. D., and Mason, P. W. (2007) J. Virol. 81, 11148-11158
55. Katsoulidis, E., Li, Y., Mears, H., and Platanias, L. C. (2005) J. Interferon Cytokine Res. 25, 749-756
56. Uddin, S., Lekmine, F., Sharma, N., Majchrzak, B., Mayer, I., Young, P. R., Bokoch, G. M., Fish, E. N., and Platanias, L. C. (2000) J. Biol. Chem. 275, 27634-27640
57. Uddin, S., Majchrzak, B., Woodson, J., Arunkumar, P., Alsayed, Y., Pine, R., Young, P. R., Fish, E. N., and Platanias, L. C. (1999) J. Biol. Chem. 274, 30127-30131
58. Krämer, O. H., Knauer, S. K., Greiner, G., Jandt, E., Reichardt, S., Gührs, K. H., Stauber, R. H., Böhmer, F. D., and Heinzel, T. (2009) Genes Dev. 23, 223-235
59. Krämer, O. H., and Heinzel, T. (2010) Mol. Cell. Endocrinol. 315, 40-48
60. Vanhatupa, S., Ungureanu, D., Paakkunainen, M., and Silvennoinen, O. (2008) Biochem. J. 409, 179-185
61. Zimnik, S., Gaestel, M., and Niedenthal, R. (2009) Nucleic Acids Res. 37, e30
62. Cheon, H., and Stark, G. R. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 9373-9378
63. Yang, J., and Stark, G. R. (2008) Cell Res. 18, 443-451
64. Beasley, D. W., Li, L., Suderman, M. T., and Barrett, A. D. (2002) Virology 296, 17-23