New antiprotozoal agents: Their synthesis and biological evaluations

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2750-2758

  Upadhayaya, Ram Shankar ^a   Dixit, Shailesh S ^a   Földesi, Andras ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Antiprotozoal agents; Conformationally constrained quinoline; Leishmania; Parasite inhibitors; Trypanosoma

Indexed keywords

AMPHOTERICIN B; ANTIPROTOZOAL AGENT; BENZNIDAZOLE; NIFURTIMOX; QUINOLINE; QUINOLINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LEISHMANIA INFANTUM; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

AMPHOTERICIN B; ANTIPROTOZOAL AGENTS; CELL LINE; CELL SURVIVAL; HUMANS; LEISHMANIA INFANTUM; NIFURTIMOX; NITROIMIDAZOLES; PARASITIC SENSITIVITY TESTS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

LEISHMANIA INFANTUM; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 84876136053     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.054     Document Type: Article

References (44)

1. WHO Neglected Diseases, http://www.who.int/neglected-diseases/en/.
2. J.R. Coura Mem. Inst. Oswaldo Cruz 102 2007 113
3. P.P. Simarro, A. Diarra, J.A. Ruiz Postigo, J.R. Franco, and J.G. Jannin PLoS Negl. Trop. Dis. 5 2011 e1007
4. E. Handman, and D.V.R. Bullen Trends Parasitol. 18 2002 332
5. WHO, World health report 2004 statistical annex. World Health Organization: 2004; p 187, ISSN 1020-3311, ISBN 92 4 156265 X, http://www.who.int/whr/2004/annex/en/index.html.
6. R.J. Pagliero, S. Lusvarghi, A.B. Pierini, R. Brun, and M.R. Mazzieri Bioorg. Med. Chem. 18 2010 142
7. WHO, Control of Chagas disease: second report of the WHO expert committee. World Health Organization, Geneva: 2002; Vol. 905, p 109, ISBN 9241209054, http://www.who.int/iris/handle/10665/42443.
8. M.E. Caputto, L.E. Fabian, D.D. Benítez, A. Merlino, N. Ríos, H. Cerecetto, G.Y. Moltrasio, A.G. Moglioni, M. González, and L.M. Finkielsztein Bioorg. Med. Chem. 19 2011 6818
9. J.R. Coura, and S.L. de Castro Mem. Inst. Oswaldo Cruz 97 2002 3
10. J.A. Urbina, and R. Docampo Trends Parasitol. 19 2003 495
11. G. Aguirre, L. Boiani, H. Cerecetto, M. Fernandez, M. Gonzalez, A. Denicola, L. Otero, D. Gambino, C. Rigol, C. Olea-Azar, and M. Faundez Bioorg. Med. Chem. 12 2004 4885
12. G. Aguirre, E. Cabrera, H. Cerecetto, R. Di Maio, M. Gonzalez, G. Seoane, A. Duffaut, A. Denicola, M.J. Gil, and V. Martinez-Merino Eur. J. Med. Chem. 39 2004 421
13. J.C. Messeder, L.W. Tinoco, J.D. Figueroa-Villar, E.M. Souza, R. Santa Rita, and S.L. de Castro Bioorg. Med. Chem. Lett. 5 1995 3079
14. M.-C. Chung, R.V.C. Güido, T.F. Martinelli, M.F. Gonçalves, M.C. Polli, K.C.A. Botelho, E.A. Varanda, W. Colli, M.T.M. Miranda, and E.I. Ferreira Bioorg. Med. Chem. 11 2003 4779
15. A.C.L. Leite, R.S. de Lima, D.R.d.M. Moreira, M.V.d.O. Cardoso, A.C. Gouveia de Brito, L.M. Farias dos Santos, M.Z. Hernandes, A.C. Kiperstok, R.S. de Lima, and M.B.P. Soares Bioorg. Med. Chem. 14 2006 3749
16. S. Gómez-Ayala, J.A. Castrillón, A. Palma, S.M. Leal, P. Escobar, and A. Bahsas Bioorg. Med. Chem. 18 2010 4721
17. S.L. Croft, S. Sundar, and A.H. Fairlamb Clin. Microbiol. Rev. 19 2006 111
18. M. Ouellette, J. Drummelsmith, and B. Papadopoulou Drug Resist. Updat. 7 2004 257
19. H. Cerecetto, R. Di Maio, M. Gonzalez, M. Risso, G. Sagrera, G. Seoane, A. Denicola, G. Peluffo, C. Quijano, A.O. Stoppani, M. Paulino, C. Olea-Azar, and M.A. Basombrio Eur. J. Med. Chem. 35 2000 343
20. J. Keiser, A. Stich, and C. Burri Trends Parasitol. 17 2001 42
21. F.A. Molfetta, A.T. Bruni, K.M. Honório, and A.B.F. da Silva Eur. J. Med. Chem. 40 2005 329
22. O. Hucke, M.H. Gelb, C.L. Verlinde, and F.S. Buckner J. Med. Chem. 48 2005 5415
23. G.I. Lepesheva, W.D. Nes, W. Zhou, G.C. Hill, and M.R. Waterman Biochemistry 43 2004 10789
24. G.I. Lepesheva, H.W. Park, T.Y. Hargrove, B. Vanhollebeke, Z. Wawrzak, J.M. Harp, M. Sundaramoorthy, W.D. Nes, E. Pays, M. Chaudhuri, F. Villalta, and M.R. Waterman J. Biol. Chem. 285 2010 1773
25. S. Shibata, J.R. Gillespie, A.M. Kelley, A.J. Napuli, Z. Zhang, K.V. Kovzun, R.M. Pefley, J. Lam, F.H. Zucker, W.C. Van Voorhis, E.A. Merritt, W.G. Hol, C.L. Verlinde, E. Fan, and F.S. Buckner Antimicrob. Agents Chemother. 2011 1982 55
26. L. Carvalho, J.R. Luque-Ortega, J.I. Manzano, S. Castanys, L. Rivas, and F. Gamarro Antimicrob. Agents Chemother. 54 2010 5344
27. J.M. Kraus, C.L.M.J. Verlinde, M. Karimi, G.I. Lepesheva, M.H. Gelb, and F.S. Buckner J. Med. Chem. 52 2009 1639
28. R.S. Upadhayaya, J.K. Vandavasi, N.R. Vasireddy, V. Sharma, S.S. Dixit, and J. Chattopadhyaya Bioorg. Med. Chem. 17 2009 2830
29. R.S. Upadhayaya, G.M. Kulkarni, N.R. Vasireddy, J.K. Vandavasi, S.S. Dixit, V. Sharma, and J. Chattopadhyaya Bioorg. Med. Chem. 17 2009 4681
30. R.S. Upadhayaya, S.V. Lahore, A.Y. Sayyed, S.S. Dixit, P.D. Shinde, and J. Chattopadhyaya Org. Biomol. Chem. 8 2010 2180
31. R.S. Upadhayaya, P.D. Shinde, A.Y. Sayyed, S.A. Kadam, A.N. Bawane, A. Poddar, O. Plashkevych, A. Foldesi, and J. Chattopadhyaya Org. Biomol. Chem. 8 2010 5661
32. R.S. Upadhayaya, P.D. Shinde, S.A. Kadam, A.N. Bawane, A.Y. Sayyed, R.A. Kardile, P.N. Gitay, S.V. Lahore, S.S. Dixit, A. Foldesi, and J. Chattopadhyaya Eur. J. Med. Chem. 46 2011 1306
33. S. Garcia, C.O. Ramos, J.F. Senra, F. Vilas-Boas, M.M. Rodrigues, A.C. Campos-de-Carvalho, R. Ribeiro-Dos-Santos, and M.B. Soares Antimicrob. Agents Chemother. 49 2005 1521
34. H.W. Rivarola, and P.A. Paglini-Oliva Curr. Drug Targets Cardiovasc. Haematol. Disord. 2 2002 43
35. Y.D. Paila, B. Saha, and A. Chattopadhyay Biochem. Biophys. Res. Commun. 399 2010 429
36. A.S. Dey, and M.M. Joullié J. Heterocycl. Chem. 2 1965 113
37. B.J. Margolis, K.A. Long, D.L. Laird, J.C. Ruble, and S.R. Pulley J. Org. Chem. 72 2007 2232
38. A. Mamo, S. Nicoletti, and N. Tat Molecules 7 2002 618
39. L. Gros, V.M. Castillo-Acosta, C. Jimenez Jimenez, M. Sealey-Cardona, S. Vargas, A. Manuel Estevez, V. Yardley, L. Rattray, S.L. Croft, L.M. Ruiz-Perez, J.A. Urbina, I.H. Gilbert, and D. Gonzalez-Pacanowska Antimicrob. Agents Chemother. 50 2006 2595
40. M. Bollini, J.J. Casal, D.E. Alvarez, L. Boiani, M. Gonzalez, H. Cerecetto, and A.M. Bruno Bioorg. Med. Chem. 17 2009 1437
41. R.A. Neal, and S.L. Croft J. Antimicrob. Chemother. 14 1984 463
42. K. Iguchi, S. Usui, R. Ishida, and K. Hirano Apoptosis 7 2002 519
43. G. Simonetti, S. Baffa, and N. Simonetti Int. J. Antimicrob. Agents 17 2001 389
44. S.S. Dixit, R.S. Upadhayaya, and J. Chattopadhyaya Org. Biomol. Chem. 10 2012 6121