New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure-activity relationships

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 4, 2009, Pages 1437-1444

  Bollini, Mariela ^a   Casal, Juan José ^a   Alvarez, Diego E ^a   Boiani, Lucía ^b   González, Mercedes ^b   Cerecetto, Hugo ^b   Bruno, Ana María ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

anti Trypanosoma cruzi agents; Imidazoisoquinolinones; QSAR

Indexed keywords

1 ACETYL 5 OXO N PHENYL 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; 5 OXO N (2 PYRIDINYL) 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; 5 OXO N PHENYL 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOXAMIDE; BENZO[4,5]IMIDAZO[1,2 B]ISOQUINOLIN 5(1H) 11 ONE; GLUTATHIONE; IMIDAZOISOQUINOLINONE DERIVATIVE; ISOQUINOLINE DERIVATIVE; N (1 NAPHTALENYL) 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; N (3 METHYLPHENYL) 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; N (4 CHLOROBENZYL) 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; N (4 CHLOROPHENYL) 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; N (4 METHOXYPHENYL) 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; N (4 METHYLPHENYL) 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; N PHENYL 11 OXOBENZO[4,5]IMIDAZO[1,2 B]ISOQUINOLIN 5(1H) 6 CARBOTHIOAMIDE; N PHENYL 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 B]ISOQUINOLIN 10 CARBOTHIOAMIDE; NIFURTIMOX; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DNA BINDING; DRUG MECHANISM; DRUG SYNTHESIS; EPIMASTIGOTE; HELA CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; CHAGAS DISEASE; DNA, PROTOZOAN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HELA CELLS; HUMANS; IMIDAZOLES; ISOQUINOLINES; MODELS, MOLECULAR; OXIDATION-REDUCTION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 60049087260     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.011     Document Type: Article

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