Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4681-4692

  Upadhayaya, Ram Shankar ^a   Kulkarni, Girish M ^a   Vasireddy, Nageswara Rao ^a   Vandavasi, Jaya Kishore ^a   Dixit, Shailesh S ^a   Sharma, Vivek ^a   Chattopadhyaya, Jyoti ^b  

^a Institute of Molecular Medicine   (India)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anti tuberculosis (anti TB) drugs; ATP synthase; Diarylquinoline; Tuberculosis

Indexed keywords

1 [3 BENZYL 2 [4 FLUORO 2 (1 HYDROXYETHYL)PHENOXY]QUINOLIN 6 YL] 3 (3 METHOXYPHENYL)UREA; 1 [3 BENZYL 2 [4 FLUORO 2 (1 HYDROXYETHYL)PHENOXY]QUINOLIN 6 YL] 3 (3 NITROPHENYL)UREA; 3 BENZYL 2 [4 FLUORO 2 (1 IMIDAZOL 1 YLETHYL)PHENOXY] 6 (4 PHENYL[1,2,3]TRIAZOL 1 YL)QUINOLINE; ANTIMYCOBACTERIAL AGENT; ARGININE; CARBONYL DERIVATIVE; GLUTAMINE; HYDROXYL GROUP; ISONIAZID; NITROGEN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; QUINOLINE; QUINOLINE DERIVATIVE; THIOUREA DERIVATIVE; TRIAZOLE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UREA; UREA DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; EVALUATION; HYDROGEN BOND; INHIBITION KINETICS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUBERCULAR AGENTS; ATP SYNTHETASE COMPLEXES; BACTERIAL PROTEINS; CELL SURVIVAL; MACROPHAGES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MURINAE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRIAZOLES; TUBERCULOSIS; UREA;

MYCOBACTERIUM TUBERCULOSIS;

EID: 66449132135     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.069     Document Type: Article

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