Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2614-2618

  Bag, Seema ^a   Ghosh, Sanjukta ^a   Tulsan, Rekha ^a   Sood, Abha ^a   Zhou, Weihong ^a   Schifone, Christine ^a   Foster, Michelle ^a   Levine III, Harry ^b   Török, Béla ^a   Török, Marianna ^a  

^a UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Chalcones; Cholinesterase inhibition; Coumarins

Indexed keywords

AMYLOID BETA PROTEIN; CHALCONE DERIVATIVE; CHOLINESTERASE; COUMARIN DERIVATIVE; OLIGOMER;

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR DOCKING;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BINDING SITES; CATALYTIC DOMAIN; CHALCONES; CHOLINESTERASE INHIBITORS; COUMARINS; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876135019     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.103     Document Type: Article

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