Synthesis and evaluation of novel chalcone derivatives with 99mTc/Re complexes as potential probes for detection of β-amyloid plaques

ACS Chemical Neuroscience

Volumn 1, Issue 9, 2010, Pages 598-607

  Ono, Masahiro ^a,b   Ikeoka, Ryoichi ^a   Watanabe, Hiroyuki ^a   Kimura, Hiroyuki ^b   Fuchigami, Takeshi ^a   Haratake, Mamoru ^a   Saji, Hideo ^b   Nakayama, Morio ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

amyloid plaque; 99mTc; Alzheimer's disease; single photon emission computed tomography(SPECT) imaging

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CHALCONE DERIVATIVE; RHENIUM COMPLEX; TECHNETIUM 99M;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RADIOACTIVITY;

Β-AMYLOID PLAQUE; 99MTC; ALZHEIMER'S DISEASE; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) IMAGING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CHALCONE; DRUG EVALUATION, PRECLINICAL; FEMALE; MICE; MICE, TRANSGENIC; PLAQUE, AMYLOID; TECHNETIUM; TISSUE DISTRIBUTION;

ANIMALIA; MUS;

EID: 77956671921     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn100042d     Document Type: Article

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