Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2801-2807

  Song, Jiangli ^a   Jones, Lindsay M ^a   Chavarria, Gustavo E ^a   Charlton Sevcik, Amanda K ^a   Jantz, Adam ^a   Johansen, Audra ^a   Bayeh, Liela ^a   Soeung, Victoria ^a   Snyder, Lindsey K ^a   Lade Jr , Shawn D ^a   Chaplin, David J ^b   Trawick, Mary Lynn ^a   Pinney, Kevin G ^a  

^a BAYLOR UNIVERSITY   (United States)

^b OXiGENE Inc   (United States)

Author keywords

Cathepsin L; Chemical synthesis; Enzyme inhibition; Small molecule inhibitors

Indexed keywords

7 BROMODIHYDROQUINOLINE THIOSEMICARBAZONE; AZEPANONE; CARBON; CATHEPSIN B; CATHEPSIN B INHIBITOR; CATHEPSIN L; CLIK 148; CLIK 195; CYSTEINE PROTEINASE INHIBITOR; DIHYDROQUINOLINE DERIVATIVE; JMP OET; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; NITROGEN; OXOCARBAZATE; OXYGEN; PURINE NITRILE; SULFONE; SULFOXIDE; SULFUR; THIOCARBAZATE; THIOCHROMAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; IC 50; STRUCTURE ACTIVITY RELATION; STUDY DESIGN;

CATHEPSIN B; CATHEPSIN L; CHROMANS; PROTEASE INHIBITORS; PROTEIN BINDING; QUINOLINES; SAFROLE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; TETRAHYDRONAPHTHALENES;

EID: 84876111616     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.025     Document Type: Article

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