-
1
-
-
36348941863
-
Bone metastasis: Pathogenesis and therapeutic implica tions
-
Clezardin P, Teti A. Bone metastasis: pathogenesis and therapeutic implica tions. Clin Exp Metastasis 2007; 24:599-608.
-
(2007)
Clin Exp Metastasis
, vol.24
, pp. 599-608
-
-
Clezardin, P.1
Teti, A.2
-
2
-
-
33749017931
-
Cysteine cathepsins: Multifunctional enzymes in cancer
-
Mohamed MM, Sloane BF. Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 2006; 6:764-775.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 764-775
-
-
Mohamed, M.M.1
Sloane, B.F.2
-
3
-
-
33846164404
-
Emerging roles of cysteine cathepsins in disease and heir potential as drug targets
-
Vasiljeva O, Reinheckel T, Peters C, et al. Emerging roles of cysteine cathepsins in disease and heir potential as drug targets. Curr Pharm Design 2007; 13:385-401.
-
(2007)
Curr Pharm Design
, vol.13
, pp. 385-401
-
-
Vasiljeva, O.1
Reinheckel, T.2
Peters, C.3
-
4
-
-
38849127573
-
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis
-
Asagiri M, Hirai T, Kunigami T, etal. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science 2008; 319:624-627.
-
(2008)
Science
, vol.319
, pp. 624-627
-
-
Asagiri, M.1
Hirai, T.2
Kunigami, T.3
-
5
-
-
40149111859
-
Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores
-
Funicello M, Novelli M, Ragni M, et al. Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores. PLoS One 2007; 2:e683.
-
(2007)
PLoS One
, vol.2
-
-
Funicello, M.1
Novelli, M.2
Ragni, M.3
-
6
-
-
34547564529
-
Cathepsin L activity controls adipogenesis and glucose tolerance
-
Yang M, Zhang Y, Pan J, et al. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol 2007; 9:970-977.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 970-977
-
-
Yang, M.1
Zhang, Y.2
Pan, J.3
-
7
-
-
0029809357
-
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
-
Gelb BD, Shi GP, Chapman HA, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 1996; 273:1236-1238.
-
(1996)
Science
, vol.273
, pp. 1236-1238
-
-
Gelb, B.D.1
Shi, G.P.2
Chapman, H.A.3
Desnick, R.J.4
-
8
-
-
0032506007
-
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
-
Saftig P, Hunziker E, Wehmeyer O, etal. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci USA 1998; 95:13453-13458.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13453-13458
-
-
Saftig, P.1
Hunziker, E.2
Wehmeyer, O.3
-
9
-
-
0034924044
-
Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K
-
Kiviranta R, Morko J, Uusitalo H, et al. Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K. J Bone Min Res 2001;16:1444-1452.
-
(2001)
J Bone Min Res
, vol.16
, pp. 1444-1452
-
-
Kiviranta, R.1
Morko, J.2
Uusitalo, H.3
-
10
-
-
33748042274
-
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: Differences between calvaria and long bone
-
Everts V, Korper W, Hoeben KA, etal. Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Min Res 2006; 21:1399-1408.
-
(2006)
J Bone Min Res
, vol.21
, pp. 1399-1408
-
-
Everts, V.1
Korper, W.2
Hoeben, K.A.3
-
11
-
-
15144356711
-
The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
-
Littlewood-Evans AJ, Bilbe G, Bowler WB, et al. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma. Cancer Res 1997; 57:5386-5390.
-
(1997)
Cancer Res
, vol.57
, pp. 5386-5390
-
-
Littlewood-Evans, A.J.1
Bilbe, G.2
Bowler, W.B.3
-
12
-
-
0037302046
-
Cathepsin K mRNA and protein expression in prostate cancer progression
-
Brubaker KD, Vessella RL, True LD, et al. Cathepsin K mRNA and protein expression in prostate cancer progression. J Bone Min Res 2003; 18:222-230.
-
(2003)
J Bone Min Res
, vol.18
, pp. 222-230
-
-
Brubaker, K.D.1
Vessella, R.L.2
True, L.D.3
-
13
-
-
35448959223
-
A cathepsin K inhibitor reduces breast cancer-induced osteolysis and skeletal tumor burden
-
Le Gall C, Bellahcène A, Bonnelye E, et al. A cathepsin K inhibitor reduces breast cancer-induced osteolysis and skeletal tumor burden. Cancer Res 2007; 67:9894-9902.
-
(2007)
Cancer Res
, vol.67
, pp. 9894-9902
-
-
Le Gall, C.1
Bellahcène, A.2
Bonnelye, E.3
-
14
-
-
33846269625
-
Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells
-
Bellahcène A, Bachelier R, Detry C, et al. Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Res Treat 2007; 101:135-148.
-
(2007)
Breast Cancer Res Treat
, vol.101
, pp. 135-148
-
-
Bellahcène, A.1
Bachelier, R.2
Detry, C.3
-
17
-
-
37549068912
-
Cathepsin Kinhibitors: Anovel targetforosteoporosis therapy
-
Stoch SA, WagnerJA. Cathepsin Kinhibitors: anovel targetforosteoporosis therapy. Clin Pharmacol Ther 2008; 83:172-176.
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 172-176
-
-
Stoch, S.A.1
WagnerJA2
-
18
-
-
38749144762
-
The discovery of odanacatib (MK- 0822), a selective inhibitor of cathepsin K
-
Gauthier JY, Chauret N, Cromlish W, etal. The discovery of odanacatib (MK- 0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett 2008; 18:923-928.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 923-928
-
-
Gauthier, J.Y.1
Chauret, N.2
Cromlish, W.3
-
19
-
-
34047274288
-
Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in variectomized mice
-
Xiang A, Kanematsu M, Kumar S, et al. Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in variectomized mice. Bone 2007; 40:1231-1237.
-
(2007)
Bone
, vol.40
, pp. 1231-1237
-
-
Xiang, A.1
Kanematsu, M.2
Kumar, S.3
-
20
-
-
37349065426
-
Cathepsin K inhibitors prevent matrix- derived growth factor degradation by human osteoclasts
-
Fuller K, Lawrence KM, Ross JL, et al. Cathepsin K inhibitors prevent matrix- derived growth factor degradation by human osteoclasts. Bone 2008; 42:200-211.
-
(2008)
Bone
, vol.42
, pp. 200-211
-
-
Fuller, K.1
Lawrence, K.M.2
Ross, J.L.3
-
21
-
-
37349029510
-
EffectofcathepsinKinhibitorbasicity on /n v/vo off-target activities
-
Provides evidence that cathepsin K inhibitors severely impair the activity of other cysteine cathepsins
-
DesmaraisS,BlackWC,OballaR,etal.EffectofcathepsinKinhibitorbasicity on /n v/vo off-target activities. Mol Pharmacol 2008; 73:145-156. Provides evidence that cathepsin K inhibitors severely impair the activity of other cysteine cathepsins.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 145-156
-
-
Desmarais, S.1
Black, W.C.2
Oballa, R.3
-
22
-
-
33751504918
-
A highly potent inhibitor ofcathepsin K (relacatib) reduces biomarkers of bone resorption both in vivo and in an acute model of elevated bone turnover in vivo in monkeys
-
Kumar S, Dare L, Vasko-Moser JA, et al. A highly potent inhibitor ofcathepsin K (relacatib) reduces biomarkers of bone resorption both in vivo and in an acute model of elevated bone turnover in vivo in monkeys. Bone 2007;40:122-131.
-
(2007)
Bone
, vol.40
, pp. 122-131
-
-
Kumar, S.1
Dare, L.2
Vasko-Moser, J.A.3
-
23
-
-
67650566593
-
Inhibition of osteolytic bone metastasesinbreastcancerwithcathepsinKinhibitor
-
abstract
-
Wesolowski G, Pickarski M, Neusch G, et al. Inhibition of osteolytic bone metastasesinbreastcancerwithcathepsinKinhibitor. JBoneMinRes2007;22 (Suppl 1):S112; abstract.
-
JBoneMinRes2007;22
, Issue.SUPPL. 1
-
-
Wesolowski, G.1
Pickarski, M.2
Neusch, G.3
-
24
-
-
33645453481
-
Regulation of cancer cell migration and bone metastasis by RANKL
-
Jones DH, Nakashima T, Sanchez OH, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature 2006; 440:692-696.
-
(2006)
Nature
, vol.440
, pp. 692-696
-
-
Jones, D.H.1
Nakashima, T.2
Sanchez, O.H.3
-
25
-
-
33744460465
-
Imatinib as a potential antire- sorptive therapy for bone disease
-
Dewar AL, Farrugia AN, Condina MR, et al. Imatinib as a potential antire- sorptive therapy for bone disease. Blood 2006; 107:4334-4337.
-
(2006)
Blood
, vol.107
, pp. 4334-4337
-
-
Dewar, A.L.1
Farrugia, A.N.2
Condina, M.R.3
-
26
-
-
40849111556
-
-
Hamdy NA. Denosumab: RANKL inhibition in the management ofbone loss. Drugs Today2008; 44:7-21.
-
Hamdy NA. Denosumab: RANKL inhibition in the management ofbone loss. Drugs Today2008; 44:7-21.
-
-
-
-
27
-
-
18144394677
-
Modulation ofbone microenvironment with zoledronateenhancesthetherapeuticeffectsofSTI571 andpaclitaxelagainst experimental bone metastasis ofhuman prostate cancer
-
Kim SJ, Uehara H, Yazici S, et al. Modulation ofbone microenvironment with zoledronateenhancesthetherapeuticeffectsofSTI571 andpaclitaxelagainst experimental bone metastasis ofhuman prostate cancer. Cancer Res 2005;65:3707-3715.
-
(2005)
Cancer Res
, vol.65
, pp. 3707-3715
-
-
Kim, S.J.1
Uehara, H.2
Yazici, S.3
|