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Volumn 10, Issue 10, 2002, Pages 3277-3284

Peptidic 1-cyanopyrrolidines: Synthesis and SAR of a series of potent, selective cathepsin inhibitors

(7) Rydzewski, Robert M a Bryant, Clifford a Oballa, Renata b Wesolowski, Gregg c Rodan, Sevgi B c Bass, Kathryn E a Wong, Darren H a

a Celera ^* (United States)

b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

c MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYANOPROLYLLEUCINE BENZYL ESTER; [1 (1 CYANO 3 PYRROLIDINYLCARBAMOYL) 3 METHYLBUTYL]CARBAMIC ACID BENZYL ESTER; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; PEPTIDE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; CATHEPSIN; DIPEPTIDE; ENZYME INHIBITOR; NITRILE;

ARTICLE; DRUG SCREENING; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; OSTEOLYSIS; STRUCTURE ACTIVITY RELATION; ANIMAL; DRUG ANTAGONISM; MOUSE; SYNTHESIS;

FELIS CATUS;

ANIMALS; BONE RESORPTION; CATHEPSINS; DIPEPTIDES; ENZYME INHIBITORS; MICE; NITRILES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036332842 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(02)00173-6 Document Type: Article

Times cited : (25)

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