Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L

ACS Medicinal Chemistry Letters

Volumn 3, Issue 6, 2012, Pages 450-453

  Song, Jiangli ^a   Jones, Lindsay M ^a   Kumar, G D Kishore ^a   Conner, Elizabeth S ^a   Bayeh, Liela ^a   Chavarria, Gustavo E ^a   Charlton Sevcik, Amanda K ^a   Chen, Shen En ^a   Chaplin, David J ^b   Trawick, Mary Lynn ^a   Pinney, Kevin G ^a  

^a BAYLOR UNIVERSITY   (United States)

^b OXiGENE Inc   (United States)

Author keywords

cathepsin B; cathepsin L; inhibitor; thiochromanone; thiosemicarbazone

Indexed keywords

CATHEPSIN L; THIOSEMICARBAZONE DERIVATIVE;

ARTICLE; BIOCHEMISTRY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; PRIORITY JOURNAL;

EID: 84862289798     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200299g     Document Type: Article

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