Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1415-1419

  Kishore Kumar, G D ^a   Chavarria, Gustavo E ^a   Charlton Sevcik, Amanda K ^a   Arispe, Wara M ^a   MacDonough, Matthew T ^a   Strecker, Tracy E ^a   Chen, Shen En ^a   Siim, Bronwyn G ^b   Chaplin, David J ^b   Trawick, Mary Lynn ^a   Pinney, Kevin G ^a  

^a BAYLOR UNIVERSITY   (United States)

^b Magdalen Centre   (United Kingdom)

Author keywords

Chemical synthesis; Inhibitors of cathepsin B; Inhibitors of cathepsin L; Molecular design; Molecular modeling

Indexed keywords

CATHEPSIN B; CATHEPSIN L; THIOSEMICARBAZONE;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; PROSTATE CANCER;

CATALYTIC DOMAIN; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; THIOSEMICARBAZONES;

EID: 75449102242     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.090     Document Type: Article

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