HPNAS-4 inhibits proliferation through S phase arrest and apoptosis: Underlying action mechanism in ovarian cancer cells

Apoptosis

Volumn 18, Issue 4, 2013, Pages 467-479

  Li, Lei ^a   Chen, Den Bang ^b   Lin, Chao ^a   Cao, Kang ^b   Wan, Yang ^a   Zhao, Xin Yu ^a   Nie, Chun Lai ^a   Yuan, Zhu ^a   Wei, Yu Quan ^a  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Ovarian cancer; PNAS 4; S phase arrest

Indexed keywords

CASPASE 3; CASPASE 9; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME C; HPNAS 4 PROTEIN; PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL FRACTIONATION; CELL PROLIFERATION; CELL SYNCHRONIZATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; CYTOSOL; DELETION MUTANT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA FRAGMENTATION; DNA REPLICATION; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE THERAPY; HUMAN; HUMAN CELL; LONG TERM SURVIVAL; OVARY CANCER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; S PHASE CELL CYCLE CHECKPOINT;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CYCLIN A; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; DNA DAMAGE; ENZYME ACTIVATION; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METHYL METHANESULFONATE; MITOCHONDRIAL PROTEINS; MITOMYCIN; OVARIAN NEOPLASMS; S PHASE CELL CYCLE CHECKPOINTS; UP-REGULATION;

EID: 84876027236     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0797-z     Document Type: Article

References (45)

1. Sherman-Baust CA, Becker KG, Wood WH III, Zhang Y, Morin PJ (2011) Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin. J Ovarian Res 4:21
2. Yu J, Zhang L (2004) Apoptosis in human cancer cells. Curr Opin Oncol 16:19-24
3. Yan F, Ruan X, Yang H, Yao S, Zhao X, Gou L et al (2010) Identification, characterization, and effects of Xenopus laevis PNAS-4 gene on embryonic development. J Biomed Biotechnol 2010:134764
4. Forrest MS, Lan Q, Hubbard AE, Zhang L, Vermeulen R, Zhao X et al (2005) Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers. Environ Health Perspect 113:801-807
5. Santin AD, Zhan F, Bignotti E, Siegel ER, Cané S, Bellone S et al (2005) Gene expression profiles of primary HPV16-and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 331:269-291
6. Best CJ, Gillespie JW, Yi Y, Chandramouli GV, Perlmutter MA, Gathright Y et al (2005) Molecular alterations in primary prostate cancer after androgen ablation therapy. Clin Cancer Res 11(19 Pt 1):6823-6834
7. Yuan Z, Liu H, Yan F, Wang Y, Gou L, Nie C et al (2009) Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene. Cancer Sci 100:1757-1766
8. Yan F, Gou L, Yang J, Chen L, Tong A, Tang M et al (2009) A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. Biochimie 91:502-507
9. Hou S, Zhao Z, Yan F, Chen X, Deng H, Wang Y et al (2009) Genetic transfer of PNAS-4 induces apoptosis and enhances sensitivity to gemcitabine in lung cancer. Cell Biol Int 33:276-282
10. Yang F, Li Z, Deng H, Yang H, Yan F, Qian Z et al (2008) Efficient inhibition of ovarian cancer growth and prolonged survival by transfection with a novel pro-apoptotic gene, hPNAS-4, in a mouse model. Oncology 75:137-144
11. Baluchamy S, Ravichandran P, Periyakaruppan A, Ramesh V, Hall JC, Zhang Y et al (2010) Induction of cell death through alteration of oxidants and antioxidants in lung epithelial cells exposed to high energy protons. J Biol Chem 285:24769-24774
12. Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL (2008) Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res 68:6698-6707
13. Lin C, Zhao X, Li L, Liu H, Cao K, Wan Y et al (2012) NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin. PLoS One 7:e36722
14. Xu X, Hamhouyia F, Thomas SD, Burke TJ, Girvan AC, McGregor WG et al (2001) Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides. J Biol Chem 276:43221-43230
15. Wei Y, Zhao X, Kariya Y, Fukata H, Teshigawara K, Uchida A (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 54:4952-4957
16. Salic A, Mitchison TJ (2008) A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci USA 105:2415-2420
17. Sinkkonen ST, Chai R, Jan TA, Hartman BH, Laske RD, Gahlen F et al (2011) Intrinsic regenerative potential of murine cochlear supporting cells. Sci Rep 1:26
18. Ruiz-Vela A, Opferman JT, Cheng EHY, Korsmeyer SJ (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6:379-385
19. Yuan Z, Cao K, Lin C, Li L, Liu H, Zhao X et al (2011) The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by BcI-xL and McI-1. Mol Med 17:1262-1274
20. Zhou B, Yan H, Li Y, Wang R, Chen K, Zhou Z et al (2012) PNAS-4 expression and its relationship to p53 in colorectal cancer. Mol Biol Rep 39:243-249
21. Gallardo D, Drazan KE, McBride WH (1996) Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity. Cancer Res 56:4891-4893
22. Sasaki H, Sheng YL, Kotsuji F, Tsang BK (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60:5659-5666
23. Wade Harper J, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816
24. Gartel AL, Tyner AL (2002) The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1:639-649
25. Beier F, Taylor AC, LuValle P (1999) The Raf-1/MEK/ERK pathway regulates the expression of the p21Cip1/Waf1 gene in chondrocytes. J Biol Chem 274:30273-30279
26. Kim GY, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E (2002) The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem 277:29792-29802
27. Park KS, Ahn Y, Kim JA, Yun MS, Seong BL, Choi KY (2002) Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibits proliferation of colorectal cancer cells. Br J Pharmacol 137:597-607
28. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632
29. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92(17):7686-7689
30. Hassepass I, Voit R, Hoffmann I (2003) Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. J Biol Chem 278:29824-29829
31. Filippov V, Filippova M, Duerksen-Hughes PJ (2007) The early response to DNA damage can lead to activation of alternative splicing activity resulting in CD44 splice pattern changes. Cancer Res 67:7621-7630
32. Fan G, Ma X, Wong P, Rodrigues C, Steer C (2004) p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells. Apoptosis 9:211-221
33. Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J et al (2000) Rapid destruction of human Cdc25A in response to DNA damage. Science 288:1425-1429
34. Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S et al (2003) Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. J Biol Chem 278:21767-21773
35. Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK et al (2003) Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 3:247-258
36. Eastman A (2004) Cell cycle checkpoints and their impact on anticancer therapeutic strategies. J Cell Biochem 91:223-231
37. Masai H, Matsumoto S, You Z, Yoshizawa-Sugata N, Oda M (2010) Eukaryotic chromosome DNA replication: where, when, and how? Annu Rev Biochem 79:89-130
38. Yeo EJ, Ryu JH, Chun YS, Cho YS, Jang IJ, Cho HS et al (2006) YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases. Cancer Res 66:6345-6352
39. Tan Y, Dourdin N, Wu C, De Veyra T, Elce JS, Greer PA (2006) Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. J Biol Chem 281:16016-16024
40. Akasaka Y, Ito K, Fujita K, Komiyama K, Ono I, Ishikawa Y et al (2005) Activated caspase expression and apoptosis increase in keloids: cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines. Wound Repair Regen 13:373-382
41. Ding H, Han C, Zhu J, Chen CS, D'Ambrosio SM (2005) Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9. Int J Cancer 113:803-810
42. Kiss T (2010) Apoptosis and its functional significance in molluscs. Apoptosis 15:313-321
43. Giansanti V, Torriglia A, Scovassi AI (2011) Conversation between apoptosis and autophagy:"Is it your turn or mine?". Apoptosis 16:321-333
44. Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR et al (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137:721-735
45. Gorvel L, Al Moussawi K, Ghigo E, Capo C, Mege JL, Desnues B (2010) Tropheryma whipplei, the Whipple's disease bacillus, induces macrophage apoptosis through the extrinsic pathway. Cell Death Dis 1:e34