Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint

Journal of Biological Chemistry

Volumn 278, Issue 32, 2003, Pages 29824-29829

  Hassepass, Ingo ^a   Voit, Renate ^a   Hoffmann, Ingrid ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; DNA; ENZYMES; IONIZING RADIATION;

DEPHOSPHORYLATION;

BIOCHEMISTRY;

CDC25A PHOSPHATASE; CELL CYCLE PROTEIN; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PHOSPHATASE; SERINE; SERINE 75; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RADIATION INJURY; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ALANINE; BLOTTING, WESTERN; CDC25 PHOSPHATASE; CELL LINE; CYCLIN E; DNA; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE TRANSFERASE; HELA CELLS; HISTIDINE; HUMANS; MODELS, BIOLOGICAL; MUTATION; PEPTIDE MAPPING; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN KINASES; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; S PHASE; SERINE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0041529687     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302704200     Document Type: Article

References (20)

1. Pines, J. (1999) Nat. Cell Biol. 1, E73-E79
2. Nyberg, K. A., Michelson, R. J., Putnam, C. W., and Weinert, T. A. (2002) Annu. Rev. Genet. 36, 617-656
3. Zhao, H., and Piwnica-Worms, H. (2001) Mol. Cell. Biol. 21, 4129-4139
4. Peng, C. Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., and Piwnica-Worms, H. (1997) Science 277, 1501-1505
5. Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S. J. (1997) Science 277, 1497-1501
6. Liu, Q., Guntuku, S., Cui, X. S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., Donehower, L. A., and Elledge, S. J. (2000) Genes Dev. 14, 1448-1459
7. Hoffmann, I., Draetta, G., and Karsenti, E. (1994) EMBO J. 13, 4302-4310
8. Blomberg, I., and Hoffmann, I. (1999) Mol. Cell. Biol. 19, 6183-6194
9. Mailand, N., Podtelejnikov, A. V., Groth, A., Mann, M., Bartek, J., and Lukas, J. (2002) EMBO J. 21, 5911-5920
10. Mailand, N., Falck, J., Lukas, C., Syljuasen, R. G., Welcker, M., Bartek, J., and Lukas, J. (2000) Science 288, 1425-1429
11. Molinari, M., Mercurio, C., Dominguez, J., Goubin, F., and Draetta, G. F. (2000) EMBO Rep. 1, 71-79
12. Bell, D. W., Varley, J. M., Szydlo, T. E., Kang, D. H., Wahrer, D. C., Shannon, K. E., Lubratovich, M., Verselis, S. J., Isselbacher, K. J., Fraumeni, J. F., Birch, J. M., Li, F. P., Garber, J. E., and Haber, D. A. (1999) Science 286, 2528-2531
13. Zhao, H., Watkins, J. L., and Piwnica-Worms, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 14795-14800
14. Shimuta, K., Nakajo, N., Uto, K., Hayano, Y., Okazaki, K., and Sagata, N. (2002) EMBO J. 21, 3694-3703
15. Superti-Furga, G., Bergers, G., Picard, D., and Busslinger, M. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 5114-5118
16. Boyle, W. J., van der Geer, P., and Hunter, T. (1991) Methods Enzymol. 201, 110-149
17. Chen, P., Luo, C., Deng, Y., Ryan, K., Register, J., Margosiak, S., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lundgren, K., Kan, C. C., and O'Connor, P. M. (2000) Cell 100, 681-692
18. Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J., and Lukas, J. (2001) Nature 410, 842-847
19. Jinno, S., Suto, K., Nagata, A., Igarashi, M., Kanaoka, Y., Nojima, H., and Okayama, H. (1994) EMBO J. 13, 1549-1556
20. Donzelli, M., Squatrito, M., Ganoth, D., Hershko, A., Pagano, M., and Draetta, G. F. (2002) EMBO J. 21, 4875-4884