In vitro models of xenobiotic metabolism in trout for use in environmental bioaccumulation studies

Xenobiotica

Volumn 43, Issue 5, 2013, Pages 421-431

  Uchea, Chibuzor ^a   Sarda, Sunil ^b   Schulz Utermoehl, Timothy ^c   Owen, Stewart ^b   Chipman, Kevin J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Shire Pharmaceuticals   (United Kingdom)

Author keywords

Biotransformation; Spheroids; Trout hepatocytes; Trout liver S9

Indexed keywords

DRUG METABOLITE; ETHOXYRESORUFIN DEETHYLASE; IBUPROFEN;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG TRANSFORMATION; ENZYME ACTIVITY; ETHOXYRESORUFIN O DEETHYLATION; FEMALE; IN VITRO STUDY; LIVER CELL; NONHUMAN; OXIDATION; PROTEIN DETERMINATION; RAINBOW TROUT; SPHEROID CELL; XENOBIOTIC METABOLISM;

ANIMALS; ENVIRONMENTAL MONITORING; MODELS, ANIMAL; MODELS, CHEMICAL; TROUT; WATER POLLUTANTS, CHEMICAL; XENOBIOTICS;

ANIMALIA; ONCORHYNCHUS MYKISS; SALMONIDAE;

EID: 84875848878     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.730644     Document Type: Article

References (57)

1. Abu-Absi SF, Hansen LK, Hu WS. (2004). Three-dimensional co-culture of hepatocytes and stellate cells. Cytotechnology 45: 125-140. (Pubitemid 40569217)
2. Altin JG, Bygrave FL. (1988). Non-parenchymal cells as mediators of physiological responses in liver. Mol Cell Biochem 83: 3-14.
3. Baron MG, Purcell WM, Jackson SK, Owen SF, Jha AN. (2012). Towards a more representative in vitro method for fish ecotoxicology: Morphological and biochemical characterisation of threedimensional spheroidal hepatocytes. Ecotoxicology. DOI: 10.1007/s10646-012-0965-5
4. Binda D, Lasserre-Bigot D, Bonet A, Thomassin M, Come MP, Guinchard C, Bars R, Jacqueson A, Richert L. (2003). Time course of cytochromes P450 decline during rat hepatocyte isolation and culture: Effect of L-NAME. Toxicol In Vitro 17: 59-67. (Pubitemid 36106492)
5. Bradford MM. (1976). A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 7: 348-254.
6. Brandon EF, Raap CD, Meijerman I, Beijnen JH, Schellens JH. (2003). An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons. Toxicol Appl Pharmacol 189: 233-246. (Pubitemid 36677534)
7. Brophy CM, Luebke-Wheeler JL, Amiot BP, Khan H, Remmel RP, Rinaldo P, Nyberg SL. (2009). Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology 49: 578-586.
8. Brown HS, Griffin M, Houston JB. (2007). Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. Drug Metab Dispos 35: 293-301. (Pubitemid 46148743)
9. Caminada D, Escher C, Fent K. (2006). Cytotoxicity of pharmaceuticals found in aquatic systems: Comparison of PLHC-1 and RTG-2 fish cell lines. Aquat Toxicol 79: 114-123. (Pubitemid 44118449)
10. Castell JV, Gomez-Lechon MJ. (2009). Liver cell culture techniques. Methods Mol Biol 481: 35-46.
11. Carlsson C, Part P. (2001). 7-Ethoxyresorufin O-deethylase induction in rainbow trout gill epithelium cultured on permeable supports: Asymmetrical distribution of substrate metabolites. Aquat Toxicol 54: 29-38. (Pubitemid 32651686)
12. Chen S, Wu K, Zhang D, Sherman M, Knox R, Yang CS. (1999). Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: Combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. Mol Pharmacol 56: 272-278. (Pubitemid 29347602)
13. Cowan-Ellsberry CE, Dyer SD, Erhardt S, Bernhard MJ, Roe AL, Dowty ME, Weisbrod AV. (2008). Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates. Chemosphere 70: 1804-1817. (Pubitemid 351192946)
14. Cross DM, Bayliss MK. (2000). A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development. Drug Metab Rev 32: 219-240. (Pubitemid 30198560)
15. Eisenbrand G, Pool-Zobel B, Baker V, Balls M, Blaauboer BJ, Boobis A, Carere A, Kevekordes S, Lhuguenot JC, Pieters R, Kleiner J. (2002). Methods of in vitro toxicology. Food Chem Toxicol 40: 193-236. (Pubitemid 34228905)
16. Erhardt S. (2008). ECO6.2-ILSIHESI: Pre-validation of an in vitro fish liver S9 assay to optimize the prediction of bioaccumulation. Available at: http://www.cefic-lri.org/projects/17/172/ECO6-2- ILSIHESI-Pre-validation. Accessed on 13 June 2012.
17. Finnson KW, Eales JG. (1998). Sulfation of thyroid hormones by liver of rainbow trout, Oncorhynchus mykiss. Comp Biochem Physiol C, Pharmacol Toxicol Endocrinol 120: 415-420. (Pubitemid 29027719)
18. Flouriot G, Vaillant C, Salbert G, Pelissero C, Guiraud JM, Valotaire Y. (1993). Monolayer and aggregate cultures of rainbow trout hepatocytes: Long-term and stable liver-specific expression in aggregates. J Cell Sci 105 (Pt 2): 407-416. (Pubitemid 23234159)
19. Flouriot G, Monod G, Valotaire Y, Devaux A, Cravedi JP. (1995). Xenobiotic metabolizing enzyme activities in aggregate culture of rainbow trout hepatocytes. Mar Environ Res 39: 293-297.
20. Gomez CF, Constantine L, Moen M, Vaz A, Wang W, Huggett DB. (2011). Ibuprofen metabolism in the liver and gill of rainbow trout, Oncorhynchus mykiss. Bull Environ Contam Toxicol 86: 247-251.
21. Gong DW, Murayama N, Yamazoe Y, Kato R. (1992). Hepatic triiodothyronine sulfation and its regulation by growth hormone and triiodothyronine in rats. J Biochem 112: 112-116.
22. Halder M, Leonard M, Iguchi T, Oris JT, Ryder K, Belanger SE, Braunbeck TA, Embry MR, Whale G, Norberg-King T, Lillicrap A. (2010). Regulatory aspects on the use of fish embryos in environmental toxicology. Integr Environ Assess Manag 6: 484-491.
23. Han X, Nabb DL, Yang CH, Snajdr SI, Mingoia RT. (2009). Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): Comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment. Environ Toxicol Chem 28: 481-488.
24. Hightower LE, Renfro JL. (1988). Recent applications of fish cell culture to biomedical research. J Exp Zool 248: 290-302. (Pubitemid 19016512)
25. Hosoda S, Nakamura W, Hayashi K. (1974). Properties and reaction mechanism of DT diaphorase from rat liver. J Biol Chem 249: 6416-6423.
26. Hussain RF, Nouri AM, Oliver RT. (1993). A new approach for measurement of cytotoxicity using colorimetric assay. J Immunol Methods 160: 89-96.
27. Hutchinson T. (2008). Intelligent testing strategies in ecotoxicology: Approaches to reduce and replace fish and amphibians in toxicity testing. NC3Rs. 14. Available at: http://www.nc3rs.org.uk/downloaddoc.asp?id=750&page= 912&skin=0
28. Ito K, Houston JB. (2005). Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches. Pharm Res 22: 103-112. (Pubitemid 40558152)
29. Johanning K, Hancock G, Escher B, Adekola A, Bernhard MJ, Cowan- Ellsberry C, Domoradzki J, Dyer S, Eickhoff C, Embry M, Erhardt S, Fitzsimmons P, Halder M, Hill J, Holden D, Johnson R, Rutishauser S, Segner H, Schultz I, Nichols J. (2012). Assessment of Metabolic Stability Using the Rainbow Trout (Oncorhynchus mykiss) Liver S9 Fraction. Curr Protoc Toxicol Chapter 14:Unit14.10.
30. Jones HS, Panter GH, Hutchinson TH, Chipman JK. (2010). Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo. Zebrafish 7: 23-30.
31. Jones HS, Trollope HT, Hutchinson TH, Panter GH, Chipman JK. (2012). Metabolism of ibuprofen in zebrafish larvae. Xenobiotica. DOI: 10.3109/00498254.2012.684410
32. Jonsson EM, Abrahamson A, Brunstrom B, Brandt I. (2006). Cytochrome P4501A induction in rainbow trout gills and liver following exposure to waterborne indigo, benzo[a]pyrene and 3,3',4,4',5-pentachlorobiphenyl. Aquat Toxicol 79: 226-232. (Pubitemid 44279080)
33. Kepp DR, Sidelmann UG, Tjornelund J, Hansen SH. (1997). Simultaneous quantitative determination of the major phase I and II metabolites of ibuprofen in biological fluids by highperformance liquid chromatography on dynamically modified silica. J Chromatogr B Biomed Sci Appl 696: 235-241. (Pubitemid 27387449)
34. Kern A, Bader A, Pichlmayr R, Sewing KF. (1997). Drug metabolism in hepatocyte sandwich cultures of rats and humans. Biochem Pharmacol 54: 761-772. (Pubitemid 27404677)
35. Khan AA, Coppock RW, Schuler MM, Geleta L. (2002). Biochemical changes as early stage systemic biomarkers of petroleum hydrocarbon exposure in rats. Toxicol Lett 134: 195-200. (Pubitemid 35012020)
36. Klaunig JE, Ruch RJ, Goldblatt PJ. (1985). Trout hepatocyte culture: Isolation and primary culture. In Vitro Cell Dev Biol 21: 221-228. (Pubitemid 15037130)
37. Lange R, Dietrich D. (2002). Environmental risk assessment of pharmaceutical drug substances-conceptual considerations. Toxicol Lett 131: 97-104. (Pubitemid 34461912)
38. Laville N, Ait-Aissa S, Gomez E, Casellas C, Porcher JM. (2004). Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes. Toxicology 196: 41-55. (Pubitemid 38220887)
39. LeCluyse EL. (2001). Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharm Sci 13: 343-368.
40. LeCluyse EL, Witek RP, Andersen ME, Powers MJ. (2012). Organotypic liver culture models: Meeting current challenges in toxicity testing. Crit Rev Toxicol 42: 501-548.
41. Lennquist A, Asker N, Kristiansson E, Brenthel A, Bjornsson BT, Kling P, Hultman M, Larsson DG, Forlin L. (2011). Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine. Comp Biochem Physiol C Toxicol Pharmacol 154: 234-241.
42. Marco-Urrea E, Perez-Trujillo M, Vicent T, Caminal G. (2009). Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor. Chemosphere 74: 765-772.
43. Mingoia RT, Glover KP, Nabb DL, Yang CH, Snajdr SI, Han X. (2010). Cryopreserved hepatocytes from rainbow trout (Oncorhynchus mykiss): A validation study to support their application in bioaccumulation assessment. Environ Sci Technol 44: 3052-3058.
44. Moorthy B, Parker KM, Smith CV, Bend JR, Welty SE. (2000). Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole. J Pharmacol Exp Ther 292: 553-560. (Pubitemid 30067418)
45. Nabb DL, Mingoia RT, Yang CH, Han X. (2006). Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat. Aquat Toxicol 80: 52-59. (Pubitemid 44416467)
46. Nichols JW, Hoffman AD, Fitzsimmons PN. (2009). Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin. Aquat Toxicol 95: 182-194.
47. Petersen K, Tollefsen KE. (2011). Assessing combined toxicity of estrogen receptor agonists in a primary culture of rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 101: 186-195.
48. Sakai Y, Tanaka T, Fukuda J, Nakazawa K. (2010a). Alkoxyresorufin O-dealkylase assay using a rat hepatocyte spheroid microarray. J Biosci Bioeng 109: 395-399.
49. Sakai Y, Yamagami S, Nakazawa K. (2010b). Comparative analysis of gene expression in rat liver tissue and monolayer- and spheroidcultured hepatocytes. Cells Tissues Organs (Print) 191: 281-288.
50. Scholz S, Segner H. (1999). Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: Concentrationresponse relationships of four model substances. Ecotoxicol Environ Saf 43: 252-260. (Pubitemid 29296005)
51. Segner H. (1998). Isolation and primary culture of teleost hepatocytes. Comp Biochem Phys A 120: 71-81. (Pubitemid 28394345)
52. Skett P. (1994). Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing- Solutions? Toxicol In Vitro 8: 491-504.
53. Van Berkel TJ, Van Tol A. (1979). Role of parenchymal and nonparenchymal rat liver cells in the uptake of cholesterolester-labeled serum lipoproteins. Biochem Biophys Res Commun 89: 1097-1101. (Pubitemid 9256454)
54. Vuppugalla R, Shah RB, Chimalakonda AP, Fisher CW, Mehvar R. (2003). Microsomal cytochrome P450 levels and activities of isolated rat livers perfused with albumin. Pharm Res 20: 81-88. (Pubitemid 36152921)
55. Walker TM, Woodrooffe AJ. (2001). Cytochrome P450 activity in control and induced long-term cultures of rat hepatocyte spheroids. Toxicol In Vitro 15: 713-719. (Pubitemid 33043960)
56. Winter MJ, Owen SF, Murray-Smith R, Panter GH, Hetheridge MJ, Kinter LB. (2010). Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: Concepts, considerations, and challenges. Integr Environ Assess Manag 6: 38-51.
57. Yang C, He WY, Kong M, Xu RM, Zhang SR, Si YK. (2000). [Use of highfield nulear magnetic resonance spectroscopy for the analysis of stereoselective metabolites of ibuprofen R-enantiomer in rat urine]. Yao Xue Xue Bao 35: 843-846.