Environmental risk assessment of pharmaceutical drug substances - Conceptual considerations

Toxicology Letters

Volumn 131, Issue 1-2, 2002, Pages 97-104

  Länge, Reinhard ^a   Dietrich, Daniel ^b  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Concepts; Pharmaceuticals; Risk assessment; Tailored approaches; Tiered testing

Indexed keywords

ABC TRANSPORTER; ANTIBIOTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALMODULIN INHIBITOR; CIPROFLOXACIN; CLOFIBRATE; CYCLOSPORIN; DIETHYLSTILBESTROL; DRUG; DRUG METABOLITE; ESTRADIOL; ESTROGEN; ETHINYLESTRADIOL; FLUOXETINE; FLUVOXAMINE MALEATE; GLYCOPROTEIN P; MESSENGER RNA; METITEPINE; METRONIDAZOLE; PAROXETINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SEROTONIN; SEROTONIN DERIVATIVE; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; STAUROSPORINE; TESTOSTERONE; UNINDEXED DRUG; VITELLOGENIN; XENOBIOTIC AGENT;

ANIMAL WELFARE; AQUATIC ENVIRONMENT; ARTICLE; CANADA; CONCENTRATION (PARAMETERS); DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SAFETY; ECOTOXICITY; EUROPE; HUMAN; LEGAL ASPECT; LONG TERM EXPOSURE; MAMMAL; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; TOXICITY TESTING; UNITED STATES; VIRILIZATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FRESH WATER; HUMANS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RISK ASSESSMENT; SEWAGE; TOXICITY TESTS;

ANIMALIA; MAMMALIA;

EID: 0037052834     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00071-1     Document Type: Article

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