Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: Combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling

Molecular Pharmacology

Volumn 56, Issue 2, 1999, Pages 272-278

  Chen, Shiuan ^a   Wu, Kebin ^a   Zhang, Di ^a   Sherman, Mark ^a   Knox, Richard ^b,d   Yang, Chung S ^c  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c RUTGERS UNIVERSITY   (United States)

^d Enzacta Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; 7,8 DIHYDROXYFLAVONE; CHRYSIN; CIBACRON BLUE F3GA; DICOUMAROL; FLAVINE ADENINE NUCLEOTIDE; HISTIDINE; MENADIONE; NICOTINAMIDE; PHENINDIONE; PROLINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SERINE; TYROSINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG STRUCTURE; ELECTRON TRANSPORT; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; X RAY ANALYSIS;

EID: 0032793633     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.2.272     Document Type: Article

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