Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes

Drug Metabolism and Disposition

Volumn 41, Issue 4, 2013, Pages 735-743

  Matsunaga, Norikazu ^a,b   Nunoya, Ken Ichi ^b   Okada, Masahiro ^b   Ogawa, Mikio ^b   Tamai, Ikumi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; DRUG METABOLITE; MULTIDRUG RESISTANCE PROTEIN 2; PAROXETINE; PAROXETINE GLUCORONIDE; PAROXETINE SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG METABOLISM; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIVER METABOLISM; MALE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENCE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CELL CULTURE TECHNIQUES; HEPATOCYTES; HUMANS; MALE; PAROXETINE; RATS; SEROTONIN UPTAKE INHIBITORS; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TRANSPORT VESICLES;

RATTUS;

EID: 84875844189     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.049817     Document Type: Article

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