Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: Comparison of two preclinical hepatic models

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 2, 2011, Pages 503-512

  Yan, Grace Zhixia ^a   Brouwer, Kim L R ^a   Pollack, Gary M ^a   Wang, Michael Zhuo ^a   Tidwell, Richard R ^b   Hall, James E ^b   Paine, Mary F ^a  

^a University of North Carolina   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 BIS (5 AMIDINO) 2 PYRIDYL FURAN; CPD 0801; FURAMIDINE; FURAN DERIVATIVE; PAFURAMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DETERMINATION; DRUG DISPOSITION; DRUG EXPOSURE; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSPORT; LIVER CELL; LIVER METABOLISM; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURAL HOMOLOGY; SYSTEMIC THERAPY;

AMIDINES; ANIMALS; BENZAMIDINES; BILE; BIOTRANSFORMATION; CELL SURVIVAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; HEPATOCYTES; LIVER; MALE; MASS SPECTROMETRY; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PRODRUGS; RATS; RATS, WISTAR;

EID: 79955021414     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.177220     Document Type: Article

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