Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes

Drug Metabolism and Disposition

Volumn 39, Issue 6, 2011, Pages 984-991

  Nakanishi, Takeo ^a   Shibue, Yuta ^a,b   Fukuyama, Yoko ^a   Yoshida, Kenji ^b   Fukuda, Hajime ^a   Shirasaka, Yoshiyuki ^a,b   Tamai, Ikumi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; DICHLOROFLUORESCEIN; MULTIDRUG RESISTANCE PROTEIN 2; RIFAMPICIN; VERLUKAST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HYDROLYSIS; HYPERBILIRUBINEMIA; IC 50; IMAGING; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; RAT; VISUAL FIELD;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE CANALICULI; CELL CULTURE TECHNIQUES; CELL MEMBRANE; CELLS, CULTURED; CYCLOSPORINE; DRUG INTERACTIONS; FLUORESCEINS; FLUORESCENT DYES; HEPATOCYTES; HYPERBILIRUBINEMIA; MALE; MICROSCOPY, FLUORESCENCE; MOLECULAR IMAGING; PHARMACEUTICAL PREPARATIONS; PROPIONATES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RIFAMPIN;

RATTUS;

EID: 79956061001     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.038059     Document Type: Article

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