Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 318, Issue 2, 2006, Pages 881-889

  Turncliff, Ryan Z ^a   Hoffmaster, Keith A ^b   Kalvass, J Cory ^a   Pollack, Gary M ^a   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACYCLONOL; DEXAMETHASONE; DRUG METABOLITE; FEXOFENADINE; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BINDING; DRUG METABOLISM; DRUG UPTAKE; ENZYME IMMUNOASSAY; HEPATOBILIARY PARAMETERS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION;

ANIMALS; BILE; BIOTRANSFORMATION; CELL SEPARATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPATOCYTES; HISTAMINE H1 ANTAGONISTS; LIVER; MALE; MASS SPECTROMETRY; MODELS, STATISTICAL; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RATS; RATS, WISTAR; TERFENADINE;

EID: 33745948311     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.102616     Document Type: Article

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