Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 365-370

  Cui, Wei ^a   Hu, Shengquan ^a   Chan, Hugh H N ^b   Luo, Jialie ^a   Li, Wenming ^a,e   Mak, Shinghung ^a   Choi, Tony Chunglit ^a   Rong, Jianhui ^c   Carlier, Paul R ^d   Han, Yifan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c THE UNIVERSITY OF HONG KONG   (Hong Kong)

^d VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

7nAChR; Akt; Bis(12) hupyridone; Glutamate; NMDA receptor

Indexed keywords

BIS(12)HUPYRIDONE; BUNGAROTOXIN RECEPTOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; HUPERZINE A; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; CELL GRANULE; CEREBELLUM; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITOTOXICITY; IC 50; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING;

ANIMALS; CELLS, CULTURED; CEREBELLUM; CHOLINESTERASE INHIBITORS; DRUGS, CHINESE HERBAL; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLONES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION;

EID: 84875810025     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.10.003     Document Type: Conference Paper

References (27)

1. A. Akaike, Y. Takada-Takatori, T. Kume, and Y. Izumi Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection J. Mol. Neurosci. 40 2010 211 216
2. D.R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B.A. Hemmings Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15 1996 6541 6551
3. M. Ankarcrona, J.M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S.A. Lipton, and P. Nicotera Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function Neuron 15 1995 961 973
4. A. Bachis, A.M. Colangelo, S. Vicini, P.P. Doe, M.A. De Bernardi, G. Brooker, and I. Mocchetti Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity J. Neurosci. 21 2001 3104 3112
5. D.A. Cantrell Phosphoinositide 3-kinase signalling pathways J. Cell Sci. 114 2001 1439 1445
6. P.R. Carlier, D.M. Du, Y.F. Han, J. Liu, E. Perola, I.D. Williams, and Y.P. Pang Dimerization of an inactive fragment of huperzine A produces a drug with twice the potency of the natural product Angew. Chem. (Int. Ed. Engl.) 39 2000 1775 1777
7. P. Chen, Z. Gu, W. Liu, and Z. Yan Glycogen synthase kinase 3 regulates N-methyl-d-aspartate receptor channel trafficking and function in cortical neurons Mol. Pharmacol. 72 2007 40 51
8. W. Cui, G.Z. Cui, W. Li, Z. Zhang, S. Hu, S. Mak, H. Zhang, P.R. Carlier, C.L. Choi, Y.T. Wong, S.M. Lee, and Y. Han Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR Brain Res. 1401 2011 10 17
9. W. Cui, W. Li, Y. Zhao, S. Mak, Y. Gao, J. Luo, H. Zhang, Y. Liu, P.R. Carlier, J. Rong, and Y. Han Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone Brain Res. 1394 2011 14 23
10. H. Fu, J. Dou, W. Li, J. Luo, K.C. Li, C.S. Lam, N.T. Lee, M. Li, and Y. Han Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms Neuropharmacology 54 2008 755 765
11. C.A. Grimes, and R.S. Jope The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65 2001 391 426
12. M. Li, D.A. Linseman, M.P. Allen, M.K. Meintzer, X. Wang, T. Laessig, M.E. Wierman, and K.A. Heidenreich Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons J. Neurosci. 21 2001 6544 6552
13. W. Li, R. Pi, H.H. Chan, H. Fu, N.T. Lee, H.W. Tsang, Y. Pu, D.C. Chang, C. Li, J. Luo, K. Xiong, Z. Li, H. Xue, P.R. Carlier, Y. Pang, K.W. Tsim, M. Li, and Y. Han Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-d-aspartate receptors J. Biol. Chem. 280 2005 18179 18188
14. W.M. Li, K.K. Kan, P.R. Carlier, Y.P. Pang, and Y.F. Han East meets West in the search for Alzheimer's therapeutics-novel dimeric inhibitors from tacrine and huperzine A Curr. Alzheimer Res. 4 2007 386 396
15. H. Lin, S. Vicini, F.C. Hsu, S. Doshi, H. Takano, D.A. Coulter, and D.R. Lynch Axonal alpha7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons Proc. Natl. Acad. Sci. USA 107 2010 16661 16666
16. S.A. Lipton Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders J. Alzheimers Dis. 6 2004 S61 S74
17. S.A. Lipton Pathologically activated therapeutics for neuroprotection Nat. Rev. Neurosci. 8 2007 803 808
18. J. Luo, W. Li, Y. Zhao, H. Fu, D.L. Ma, J. Tang, C. Li, R.W. Peoples, F. Li, Q. Wang, P. Huang, J. Xia, Y. Pang, and Y. Han Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-d-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin J. Biol. Chem. 285 2010 19947 19958
19. A. Maelicke, A. Schrattenholz, M. Samochocki, M. Radina, and E.X. Albuquerque Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease Behav. Brain Res. 113 2000 199 206
20. R. Pi, W. Li, N.T. Lee, H.H. Chan, Y. Pu, L.N. Chan, N.J. Sucher, D.C. Chang, M. Li, and Y. Han Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways J. Neurochem. 91 2004 1219 1230
21. S. Roman, A. Badia, P. Camps, and M.V. Clos Potentiation effects of (+/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes Neuropharmacology 46 2004 95 102
22. H. Shen, T. Kihara, H. Hongo, X. Wu, W.R. Kem, S. Shimohama, A. Akaike, T. Niidome, and H. Sugimoto Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors Br. J. Pharmacol. 161 2010 127 139
23. S. Shimohama, A. Akaike, and J. Kimura Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation Ann. NY. Acad. Sci. 777 1996 356 361
24. Y. Takada-Takatori, T. Kume, M. Sugimoto, H. Katsuki, H. Sugimoto, and A. Akaike Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade Neuropharmacology 51 2006 474 486
25. H.S. Ved, M.L. Koenig, J.R. Dave, and B.P. Doctor Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate Neuroreport 8 1997 963 968
26. B.S. Wang, H. Wang, Z.H. Wei, Y.Y. Song, L. Zhang, and H.Z. Chen Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis J. Neural Transm. 116 2009 457 465
27. H. Yu, W.M. Li, K.K. Kan, J.M. Ho, P.R. Carlier, Y.P. Pang, Z.M. Gu, Z. Zhong, K. Chan, Y.T. Wang, and Y.F. Han The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine J. Pharm. Biomed. Anal. 46 2008 75 81