Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons

Journal of Neuroscience

Volumn 21, Issue 17, 2001, Pages 6544-6552

  Li, Mingtao ^a   Linseman, Daniel A ^a   Allen, Melissa P ^a   Meintzer, Mary Kay ^a   Wang, Xiaomin ^a   Laessig, Tracey ^a   Wierman, Margaret E ^a   Heidenreich, Kim A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Caspase; Cerebellum; MEF2; Neurons; Transcription

Indexed keywords

CASPASE; MUTANT PROTEIN; MYOCYTE ENHANCER FACTOR 2A; MYOCYTE ENHANCER FACTOR 2D; POTASSIUM; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DNA BINDING; DNA PROTEIN COMPLEX; GENETIC TRANSCRIPTION; GRANULE CELL; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0035448912     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-17-06544.2001     Document Type: Article

References (33)

1. Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle
2. Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
3. Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells. Association with the activated phenotype
4. Regulatory role of MEF2D in serum induction of the c-jun promoter
5. Expression of a MADS-box gene, MEF2D, in neurons of the mouse central nervous system: Implication of its binary function in myogenic and neurogenic cell lineages
6. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
7. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex
8. Myocyte-specific enhancer binding factor 2C expression in human brain development
9. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity
10. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β
11. The expression of MEF2 genes is implicated in CNS neuronal differentiation
12. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
13. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
14. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
15. Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons
16. Neuronal activity-dependent cell survival mediated by transcription factor MEF2
17. A MEF2 gene that generates a muscle-specific isoform via alternative mRNA splicing
18. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors
19. Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization and insulin-like growth factor I-mediated survival of cerebellar granule cells
20. HDAC4 deacetylase associates with and represses the MEF2 transcription factor
21. Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors
22. MEF2B is a potent transactivator expressed in early myogenic lineages
23. MEF2: A transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
24. Antiapoptotic role of the p38 mitogen-activated protein kinase - Myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation
25. A dominant-negative form of transcription factor MEF2 inhibits myogenesis
26. Post-translational control of the MEF2A transcriptional regulatory protein
27. The MADS-box family of transcription factors
28. Myocyte enhancer factor 2C upregulates MASH-1 expression and induces neurogenesis in P19 cells
29. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1
30. 2+-induced release of the transcription factor MEF2
31. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4
32. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS-box transcription factors
33. Regulation of the MEF2 family of transcription factors by p38