Preventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone

Brain Research

Volumn 1394, Issue , 2011, Pages 14-23

  Cui, Wei ^a   Li, Wenming ^a   Zhao, Yuming ^b   Mak, Shinghung ^a   Gao, Yang ^c   Luo, Jialie ^a   Zhang, Huan ^a   Liu, Yuqing ^a   Carlier, Paul R ^d   Rong, Jianhui ^e   Han, Yifan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c MAYO GRADUATE SCHOOL   (United States)

^d VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^e THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bis(12) hupyridone; Hydrogen peroxide; Neurodegenerative disorder; Oxidative stress; Vascular endothelial growth factor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHOLINESTERASE INHIBITOR; DIMERIC ANTIACETYLCHOLINESTERASE BIS (12) HUPYRIDONE; GLYCOGEN SYNTHASE KINASE 3BETA; HUPERZINE A; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; NEOSTIGMINE; TACRINE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VATALANIB; WORTMANNIN; ACETYLCHOLINESTERASE; BIS(12) HUPYRIDONE; BIS(12)-HUPYRIDONE; ENZYME INHIBITOR; NEUROPROTECTIVE AGENT; OXIDIZING AGENT; PROTEIN KINASE B; QUINOLONE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL LOSS; CEREBELLAR GRANULE NEURON; CEREBELLUM; ENZYME ACTIVITY; ENZYME INHIBITION; GRANULE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECT; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ACETYLCHOLINESTERASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME INHIBITORS; HYDROGEN PEROXIDE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDANTS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 79956272964     PISSN: 00068993     EISSN: 00068993     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.02.006     Document Type: Article

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